Hongyao Chen

Severity of drug dependence, economic pressure and HIV-related risk behaviors among non-institutionalized female injecting drug users who are also sex workers in China.

BACKGROUND Female injecting drug users (IDUs) who are also sex workers (FSW-IDUs) is an important bridge population transmitting HIV from the IDU population to clients of FSWs. Little is known about the relationships between severity of drug dependence, economic pressure and relevant HIV-related risk behaviors. METHODS 281 non-institutionalized participants were recruited using snowball sampling methods. Anonymous face-to-face interviews were administered by trained doctors. RESULTS 64.1% of participants used condoms inconsistently with their clients in the past 6 months; 28.5% served at least 2 clients per day and 48.4% practiced at least one of the three studied needle sharing behaviors. Severity of drug dependence (adjusted OR=1.05, p<0.01) and economic pressure (adjusted OR=1.07 to 2.52, p<0.05) were significantly associated with inconsistent condom use with clients in the last 6 months. Severity of drug dependence (adjusted OR=1.15, p<0.01) and variables related to perceived economic pressure (adjusted OR=1.09-3.05, p<0.05) were significantly associated with higher frequency of commercial sex transaction. Severity of drug dependence (adjusted OR=1.07, p<0.01) were also associated with needle sharing behaviors. In summary models, severity of drug dependence (OR=1.17, p<0.001), economic pressure (OR=1.39, p<0.001) and their interaction term (OR=0.98, p<0.001) were all associated with inconsistent condom use with clients in the last 6 months. CONCLUSIONS Prevalence of unprotected commercial sex was high and was independently associated with severity of drug dependence and economic pressure; severity of drug dependence was also associated with needle sharing behaviors. Such issues need to be fully considered when planning research studies and interventions.

Using the Theory of Planned Behavior to investigate condom use behaviors among female injecting drug users who are also sex workers in China

Abstract Female injecting drug users who are sex workers (IDUFSWs) is a strategic “bridge population” for HIV transmission. Goals of the study were to investigate condom use behaviors during commercial sex among IDUFSWs using the Theory of Planned Behavior (TPB), and to investigate moderating effects that modify the strength of associations between the TPB-related variables and inconsistent condom use during commercial sex. A total of 281 non-institutionalized IDUFSWs were recruited using snowball sampling method. Anonymous face-to-face interviews were administered by trained doctors. The results showed that the prevalence of inconsistent condom use during commercial sex in the last six months was 64%. After adjusting for some significant background variables (e.g. main venue of sex work), all associations between the five TPB-related variables and the studied condom use variable were statistically significant (Odds Ratio (OR) = 0.43–0.68, p<0.001). In the hierarchical nested models, three background variables (age, venue of sex work, and ever used HIV-related interventions) entered in the first step (−2LL = 294.98, p<0.001) and the Social Norm Scale, the Perceived Behavioral Control Scale and the Behavioral Intention Scale were selected by the second step (OR = 0.67 − 0.72, p<0.01; −2LL = 160.99, p<0.001). Significant moderating effects between some TPB-related variables (Positive Condom use Attitude Scale and Behavioral Intention Scale) and duration of sex work and duration of drug use were also reported. The results highlighted the potential of using the TPB to better understand condom use behaviors in IDUFSWs in China. Theory-based research and intervention work should be developed in China in the future.

Prevalence of needle sharing, commercial sex behaviors and associated factors in Chinese male and female injecting drug user populations.

Abstract The objective of this study is to investigate prevalence and associated factors of commercial sex behaviors and condom use at commercial sex, as well as prevalence of needle sharing among injecting drug users (IDUs) in China. In this study, 162 IDUs were recruited by peer workers in Dazhou, Sichuan and were anonymously interviewed by using a structured questionnaire. Univariate and multivariate logistic regression analyses were performed and interaction between gender and the studied independent variables were tested for significance. The results of this study showed that the male and female respondents, respectively 11.7 and 16.9% were HIV positive; 34.0 and 40.7% engaged in commercial sex and 23.3 and 11.9% shared needles with others in the last six months. Percent using a condom in the last episode of commercial sex was 30.3% for males and 76.2% for females. The multivariate analyses showed that higher drug dosage (OR=0.3, 95% CI: 0.1–0.9) and reduced sexual drive (OR=0.3, 95% CI: 0.1–0.9) were associated with lower likelihood for commercial sex among male IDUs while higher drug dosage (OR=9.1, 95% CI: 1.0–86.0), perceived difficulty in finding a job (OR=5.1, 95% CI: 1.3–20.1) and lack of family support (OR=4.0, 95% CI: 1.1–15.4) were associated with commercial sex among female IDUs. Similarly, unknown HIV status (OR=8.2, 95% CI: 1.7–9.2) and having a regular sex partner (OR=3.7, 95% CI: 1.3–10.9) was associated with needle sharing. It is concluded that male and female IDUs were sexually active and often engaged in commercial sex. Drug dosage and reduced sexual drive were relevant but did not stop commercial sex behaviors. More supportive social environment is required to prevent female IDUs to enter sex work.

Evaluation of the overall program effectiveness of HIV-related intervention programs in a community in Sichuan, China.

Objectives: The study evaluates the overall effectiveness of intervention programs among female sex workers in a Chinese community. Study Design: Behavioral surveillance data in 2003, 2004, and 2005 obtained from 2 communities (intervened and control) were compared. Results: The baseline data (2003) of the 2 counties were not significantly different. In 2004 and 2005, the intervened county had significantly higher prevalence of condom use with their clients and regular sex partners (last-time and consistent use in the last month; OR = 2.2-33.2 in 2004 and 3.8-8.3 in 2005), higher HIV-related knowledge level (OR = 7.9 in 2004 and 17.3 in 2005), and lower STD prevalence (OR = 0.22 in 2004 and 0.11 in 2005). Coverage rates of HIV antibody testing and HIV-related services increased in the intervened county but decreased in the control county. Conclusions: Intervention programs may result in substantial behavioral changes in a community within a few years.

Prevalence and associated factors of condom use during commercial sex by female sex workers who were or were not injecting drug users in China

OBJECTIVES We compared the prevalence of inconsistent condom use during commercial sex between female sex workers (FSWs) who did or did not inject drugs (FSW-IDUs and FSW-NIDUs) and investigated factors associated with this inconsistent use within these two groups. METHODS Some 158 FSW-NIDUs recruited from sex work venues and 218 FSW-IDUs recruited via the snowball sampling method were interviewed anonymously. RESULTS Only 16.5% of the FSW-IDUs and 51.3% of the FSW-NIDUs had used condoms consistently during commercial sex in the last month (odds ratio (OR)=0.19). Factors significantly associated with inconsistent condom use in both groups included: behavioural intention for condom use (adjusted odds ratio (AOR)=0.05 and 0.13), condom unavailability (AOR=4.77 and 5.33), a perceived need to engage in unprotected sex if the client paid more (AOR=8.74 and 10.84) or insisted on demanding unprotected sex (AOR=19.78 and 7.59), and submissive gender power (AOR=11.65 and 2.58). One factor, perceived susceptibility (AOR=2.64), was significant only among FSW-NIDUs, whereas perceived efficacy of condom use in preventing HIV transmission (AOR=0.08), perceptions that peer FSWs would not use condoms with clients (AOR=2.23), self-hatred (AOR=2.25) and lack of social support (AOR=2.93) were significant only among FSW-IDUs. Injecting with used syringes was also associated with inconsistent condom use among FSW-IDUs (AOR=4.64). CONCLUSIONS FSW-IDUs were more likely than FSW-NIDUs to possess the cognitive and psychosocial conditions associated with unprotected commercial sex. Interventions need to take these differences into account.

Validation of the Chinese version of the Opiate Addiction Severity Inventory (OASI) and the Severity of Dependence Scale (SDS) in non-institutionalized heroin users in China

No fully validated Chinese instrument measuring severity of drug dependence exists. The Chinese Opiate Addiction Severity Inventory (OASI) and the translated Chinese version of the Severity of Dependence Scale (SDS) were validated in this study. A total of 178 eligible participants were recruited using snowballing method. The 11-item revised version of OASI (OASI-R) exhibited good reliability (item-total correlation coefficients ranged from 0.50 to 0.73, Cronbachs alpha was 0.85, test-retest Intra-class Correlation Coefficient was 0.81, p < 0.001). Two factors were identified by principal component method and correlated significantly with the Quality of Life-Drug Addiction (QOL-DA). The 3-item revised version of SDS (SDS-R) was one of the two factors of SDS (item-total correlation coefficients were 0.79 to 0.86, Cronbachs alpha was 0.78, test-retest Intra-class Correlation Coefficient was 0.64, p < 0.001). It correlated significantly with QOL-DA. OASI-R and SDS-R were also significantly correlated with each other and with some heroin-related characteristics. The validation of the Chinese version of OASI-R and SDS-R would facilitate research in different Chinese populations. SDS has been translated to different languages and the Chinese version allows for international comparison.

Prevalence of depressive symptoms and associated factors among people who inject drugs in China

BACKGROUND People who inject drugs (PWID) have a high prevalence of mental health problems (e.g., depression) which compromise the effects of HIV prevention. We investigated the prevalence of depression and associated factors among PWID in Dazhou, China. METHODS Anonymous face-to-face interviews were administered to eligible participants by well-trained doctors. The Center of Epidemiological Studies Depression Scale (CES-D) was used to measure depression, using hierarchical linear regression models. RESULTS Among the 257 participants, 7.0%, 11.3%, and 75.1% were probable cases of mild (16 ≤ CES-D < 21), moderate (21 ≤ CES-D < 25), and severe (CES-D ≥ 25) depression, respectively. Hopefulness (standardized β = -0.34, p < 0.001) and emotional family support (β = -0.21, p < 0.001) were negatively associated, whereas severity of drug dependence (β = 0.12, p = 0.034) and unmet service needs (β = 0.20, p < 0.001) were positively associated, respectively, with CES-D scores. The adjusted analysis showed that resilience was negatively associated with CES-D, but it was not selected by the stepwise model containing hopefulness and emotional family support. Protective factors (i.e., hopefulness and emotional family support) and risk factors (i.e., severity of drug dependence and unmet service needs) remained significant in the same regression model. CONCLUSION Protective and risk factors were independently associated with depressive symptoms. Integrated interventions covering basic and psychosocial needs for PWID are warranted. Such interventions should strengthen emotional family support and cultivate positive factors such as hopefulness.

Anticipated suicidal ideation among female injecting drug users who are sex workers of negative or unknown HIV status in China

ABSTRACT In China, female injection drug users who are also sex workers (IDUFSW) have a high prevalence of HIV and low prevalence of HIV testing. They are concerned about HIV infection and may be subjected to the risk of suicidal ideation if they become infected, due to stress and discrimination. During 2005–2006, we recruited 199 IDUFSW who self-reported negative/unknown HIV sero-status in Dazhou, Sichuan, China, to investigate the prevalence of and factors associated with suicidal ideation if they became HIV positive. Among the participants, 40.7% responded affirmatively to the question “Whether you would commit suicide if you were infected with HIV in the future?” In multivariate analyses, hatred toward oneself, perception of dying within 2–3 years, perceived nonavailability of HIV-related treatment, inability to cope with HIV-related trauma, and inclination to leave one’s family if one contracted HIV were significant factors related to anticipated suicidal ideation under the hypothetical situation of HIV infection. The odds ratios (OR) ranged from 2.38 to 10.36 (p < .05). These findings can facilitate the planning of primary suicidal prevention services targeting high-risk, non-HIV-positive IDUFSW. Such programs may enhance psychosocial support, empowerment, cultivation of positive coping strategies, and perceived accessibility to treatment, and be integrated with HIV testing.

How likely are HIV-positive female sex workers in China to transmit HIV to others?

BACKGROUND Female sex workers (FSW) are highly marginalised and HIV-positive FSW are under a double stigma. No study has assessed the likelihood of secondary transmission via HIV-positive FSW in China. METHODS A total of 199 FSW who injected drugs were recruited by snowball sampling, and 158 non-injecting FSW were recruited from sex service establishments by convenience sampling in Dazhou, China. All participants were interviewed anonymously using a structured questionnaire. RESULTS If found to be HIV-positive, 11.7% of the participants would continue working as FSW, 24.6% would not care about transmitting HIV to others, 18.8% believed that they would eventually spread HIV to others and 9% would take revenge by spreading HIV to others. In multivariate models, factors associated with ≥ 1 of the four aforementioned perceptions (42.0%) included drug use (odds ratio (OR)=1.82-3.26, P<0.01), perceived discrimination towards people living with HIV and AIDS in China (OR=2.03, P<0.05) and perceived inaccessibility to medical treatments if diagnosed as HIV-positive (OR=2.30, P<0.01); the reverse was true for use of HIV-related services (OR=0.53, P<0.05) and suicidal intentions if found to be HIV-positive (OR=0.42, P<0.05). CONCLUSIONS Improvement of the social, care and medical environment of HIV-positive FSW is likely to reduce secondary transmission via HIV-positive FSW. Special attention should be given to FSW who inject drugs.