Horst Lenzen
University of Münster
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Featured researches published by Horst Lenzen.
European Radiology | 1999
Ulrich Bick; Horst Lenzen
Abstract. More than 15 years ago the idea of a Picture Archiving and Communication System (PACS) and a filmless hospital was created. In a PACS environment images are acquired, read, communicated and stored digitally. After many years of unsuccessful attempts and prototype installations, the necessary hardware components for a successful PACS installation are now readily available. However, software development is still lagging behind. Only very recently, software developers have realized that it is not sufficient for PACS software to store, communicate and display images, but that PACS software should effectively support the radiologist in the task of interpreting and communicating imaging findings through context-dependent default display arrangements, work-flow management, radiological and hospital information systems integration, and computer-assisted diagnosis. This review examines hard- and software requirements for efficient PACS operation, analyses costs and benefits, and discusses future developments.
European Radiology | 1998
Karl Ludwig; Ulrich Bick; Michael Oelerich; Gerhard Schuierer; Z. Puskas; K. Nicolas; A. Koch; Horst Lenzen
Abstract. This study examines the suitability of working with a selection of images in a teleradiology consulting system in neurological or neurosurgical emergency situations. The teleradiology system was based on IBM-compatible personal computers, video digitization for data acquisition, and data transmission by Integrated System Digital Network. Forty normal and 60 abnormal emergency cranial computed tomograms were shown to a radiologist on call who presented all cases he regarded as pathologic to a neuroradiologic expert by teleradiology. To reduce transmission time, only a selection of images from the CT study was presented (up to four images per case). For each case the on-call radiologists diagnosis (Don-call), the experts diagnosis on the teleradiology screen (Dmonitor), and the experts diagnosis on the original film (Doriginal) was documented, together with an estimation of the agreement between those diagnoses. There was clinically relevant disagreement between the on-call radiologists diagnosis and the neuroradiologists diagnosis based on the image selection on the teleradiology monitor in 23 % of cases. A clinically important discrepancy between the neuroradiologists diagnosis based on the image selection and his diagnosis using the original films was found in 30 % of cases. This was due to the presence of clinically relevant information on images not transferred by the on-call radiologist. Image quality of the transferred images was sufficient in all cases. Drastic selection of images from a complete CT study leads to a high rate of incorrect diagnoses and is not appropriate to reduce transmission time in teleradiology.
European Radiology | 2002
Karl Ludwig; Andreas Henschel; Thomas M. Bernhardt; Horst Lenzen; Dag Wormanns; Stefan Diederich; Walter Heindel
Abstract.The purpose of this study was to compare a large-area, direct-readout, flat-panel detector system with a conventional screen-film system, a storage-phosphor system, and a mammography screen-film system with regard to the detection of artificial bone erosions simulating rheumatoid disease, and to assess its diagnostic performance with decreasing exposure dose. Six hundred forty regions were defined in 160 metacarpophalangeal and proximal interphalangeal joint specimens from 20 monkey paws (4 regions per joint). Artificial bone erosions were created in 320 of these 640 regions. Specimens were enclosed in containers filled with water to obtain absorption and scatter radiation conditions similar to those of a human hand. Imaging was performed using a flat-panel system, a speed class 200 screen-film system, a mammography screen-film system, and a storage-phosphor system under exactly matched conditions. Different exposure doses equivalent to speed classes of S=100, 200, 400, 800, 1600, and 3200 were used. In all images the presence or absence of a lesion was assessed by three radiologists using a five-level confidence scale. Receiver operating characteristic (ROC) analysis was performed for a total of 21,120 observations (1920 for each imaging modality and exposure level) and diagnostic performance estimated by the area under the ROC curve (Az). The significance of differences in diagnostic performance was tested with analysis of variance. The ROC analysis showed Az values of 0.809 (S=200), 0.768 (S=400), 0.737 (S=800), 0.710 (S=1600), and 0.685 (S=3200) for the flat-panel system, 0.770 for the speed class 200 screen-film system, 0.781 (S=200), 0.739 (S=400), 0.724 (S=800), 0.680 (S=1600) for the storage-phosphor system, and 0.798 for the mammography screen-film system. Analysis of variance showed significant differences between different combinations of imaging modalities and exposure doses ( p <0.05). The diagnostic performance of the flat-panel detector system is superior to that of a screen-film system and a storage-phosphor system for the detection of erosive lesions at clinical exposure settings (S=200). Using the flat-panel system the exposure dose can be reduced by 50% to obtain a diagnostic performance comparable to a speed class 200 screen-film system.
Radiology | 2014
Stefanie Weigel; Shoma Berkemeyer; R Girnus; A Sommer; Horst Lenzen; Walter Heindel
PURPOSE To assess screening performance of a direct radiography (DR) photon-counting system versus statewide screening units with different digital technologies. MATERIALS AND METHODS The local ethics board approved retrospective study of prospectively acquired data from the North Rhine-Westphalian mammography screening program (2009-2010). Informed consent was waived. Examinations in 13 312 women with a DR photon-counting system and statewide digital screening examinations in 993 822 women were included (37 computed radiography mammography systems and 55 DR systems). Diagnostic performance was assessed with cancer detection rate, recall rate, and proportion of small invasive cancers and ductal carcinoma in situ (DCIS). Mean glandular dose was calculated for DR photon counting and for a conventional DR subgroup. Differences were tested with χ(2) and t tests (P < .05). RESULTS The cancer detection rate for subsequent screenings was higher for DR photon counting than statewide rates (0.76% [67 of 8842] vs 0.59% [3108 of 527 194], P = .05) at a higher recall rate (5.4% [475 of 8842] vs 3.3% [17 656 of 527 194], P = .001). Detection of invasive cancers up to 10 mm for DR photon counting was high for initial (40% [14 of 35]) and subsequent (42% [19 of 45]) screenings but not significantly different from statewide rates (initial, 31.6% [942 of 2979], P = .50; subsequent, 32.5% [765 of 2353], P = .25). The DCIS subsequent screening rate was higher for DR photon counting than statewide screening (0.23% [20 of 8842] vs 0.12% [616 of 527 194], P = .01) and the conventional DR subgroup (0.23% [20 of 8842] vs 0.12% [65 of 52 813], P = .025). Mean glandular dose for DR photon counting was significantly lower than that for conventional DR (0.60 mGy ± 0.20 vs 1.67 mGy ± 0.47 [craniocaudal views], 0.64 mGy ± 0.23 vs 1.79 mGy ± 0.53 [mediolateral oblique views], both P = .0001). CONCLUSION Digital mammography screening with dose-efficient photon counting enables desirable detection rates of small invasive cancers and DCIS. Higher detection rates compared with statewide performance occurred with subsequent screening but had higher recall rates.
Investigative Radiology | 2004
Thomas M. Bernhardt; Ulrike Rapp-Bernhardt; Horst Lenzen; Friedrich W. Röhl; F. Stefan Diederich; Karsten Papke; Karl Ludwig; Walter Heindel
Rationale and Objectives:To evaluate a large area, cesium iodide amorphous silicon flat-panel detector (CsI/a-Si) at 3 tube voltages to detect simulated interstitial lung disease, nodules, and catheters. Methods:Simulated interstitial lung disease, nodules, and catheters were superimposed over a chest phantom. Images were generated at 125 kVp, 90 kVp, and 70 kVp at the same surface dose and reduced effective dose equivalent for 90 kVp and 70 kVp and printed on hard copies. Fifty-four thousand observations were analyzed by receiver operating characteristic (ROC). Results:Detectability of linear, miliary, reticular pattern, and nodules over lucent lung as well as of catheters and nodules over obscured chest areas increased at 90 and/or 70 kVp with higher Az values; however, only it was statistically significant for reticular pattern at 70 kVp and nodules at 90 kVp compared with 125 kVp (P <0.05). The detection of ground-glass pattern was worse at lower kVp (P >0.05). Conclusion:For most simulated patterns, differences in diagnostic performance at 70 kVp/90 kVp and 125 kVp were not significant, except for reticular pattern and nodules over lucent lung.
Investigative Radiology | 2005
Ulrike Rapp-Bernhardt; Friedrich-Wilhelm Roehl; Rainer Esseling; Horst Lenzen; Manfred Schiborr; Iris Theobald-Hormann; Walter Heindel; Thomas M. Bernhardt
Objective:We sought to evaluate the diagnostic performance of a portable indirect flat-panel detector for low-dose imaging as compared with an asymmetric film-screen system in a pediatric intensive care unit. Materials and Methods:A total of 120 neonates underwent chest radiographs using a portable flat-panel detector (digital speed 800) and an asymmetric film-screen system (400 speed). Four readers evaluated the detection of 11 anatomic and 5 pathologic landmarks and 4 support devices. Statistical analysis was performed using repeated analysis of variance. The level of statistical significance was P = 0.05. Results:The detection of 4 anatomic/4 pathologic landmarks and 2 support devices was significantly better using the flat-panel detector as compared with the asymmetric film-screen system (P < 0.05). Another 8 anatomic and one pathologic landmarks were detected equally well or slightly better with the flat-panel detector (P > 0.05). Conclusions:The portable flat-panel detector offers the potential of a 50% dose reduction with equal or significantly better detection of clinically important structures.
European Radiology | 1993
Ulrich Bick; R. Hentschel; Martin Fiebich; C. Müller-Leisse; N. Ross; W. Wiesmann; Horst Lenzen; H.-J. v. Lengerke; Peters Pe
In order to evaluate the influence of radiation exposure on image quality in digital storage phosphor radiography, 200 digital storage phosphor chest radiographs, obtained on a neonatal Intensive Care Unit, and the same number of conventional screen-film radiographs (speed 250) were assessed for the visibility of anatomical structures and catheters. The same exposure parameters were used in both groups. Normal variations of radiation exposure under free exposure conditions were estimated in all digital images using a formula calculating radiation dose in the screen-plane from image sensitivity, latitude and average grey value of the right lung. There was already a significant (P < 0.001) decline in image quality in the digital images with a 30–50% reduction in radiation exposure, which was most severe for structures such as trachea, retrocardiac space, lung texture and low-contrast catheters. Compared with optimally exposed conventional images, only those digital images with a slightly higher than normal dose had an equivalent image quality.
Rofo-fortschritte Auf Dem Gebiet Der Rontgenstrahlen Und Der Bildgebenden Verfahren | 2014
K Entz; A Sommer; Walter Heindel; Horst Lenzen
PURPOSE To determine the number of extra images (EI) that are necessary for imaging large breasts when using a detector smaller than 24 cm × 30 cm and to calculate the additional average glandular dose (AGD) for these images. MATERIALS AND METHODS The screening mammograms taken between 2007 and 2011 were assessed for a photon counting full-field digital mammography (PCM) system (detector size: 24 cm × 26 cm) and a computed radiography (CR) system (24 cm × 30 cm). The number of EI was recorded and the AGD calculated. This AGD was compared with the mean AGD of 47 conventional full-field digital mammography (FFDM) systems. RESULTS A total of 62,466 examinations were analyzed. EI had to be taken in 0.6 % (199/32,766) of all PCM examinations and 0.3 % (90/29 700) of all CR examinations. This corresponded to a total of 327 and 191 EI for the PCM and CR systems, respectively. More than one quarter of the examinations with EI were necessary because the breast was not properly positioned in the original image (PCM 31 %, CR 29 %). The mean AGD per EI was 0.7 ± 0.1 mGy for the PCM and 2.6 ± 1.2 mGy for the CR system. The mean AGD for all breast thicknesses for FFDM was 1.4 ± 0.3 mGy. CONCLUSION In general, large breasts cannot be imaged with just one image per view. The number of examinations where EI are needed is doubled with the 24 cm × 26 cm detector of the PCM system. However, the absolute number is small. The total dose, as the sum of the original and the EI, is equal to the mean AGD of a single image of the FFDM systems and lower than the dose of a single image with the CR system.
Rofo-fortschritte Auf Dem Gebiet Der Rontgenstrahlen Und Der Bildgebenden Verfahren | 2011
J Czwoydzinski; R Girnus; A Sommer; Walter Heindel; Horst Lenzen
PURPOSE Physical-technical quality assurance is one of the essential tasks of the National Reference Centers in the German Breast Cancer Screening Program. For this purpose the mammography units are required to transfer the measured values of the constancy tests on a daily basis and all phantom images created for this purpose on a weekly basis to the reference centers. This is a serious logistical challenge. To meet these requirements, we developed an innovative software tool. MATERIALS AND METHODS By the end of 2005, we had already developed web-based software (MammoControl) allowing the transmission of constancy test results via entry forms. For automatic analysis and transmission of the phantom images, we then introduced an extension (MammoControl DIANA). This was based on Java, Java Web Start, the NetBeans Rich Client Platform, the Pixelmed Java DICOM Toolkit and the ImageJ library. RESULTS MammoControl DIANA was designed to run locally in the mammography units. This allows automated on-site image analysis. Both results and compressed images can then be transmitted to the reference center. We developed analysis modules for the daily and monthly consistency tests and additionally for a homogeneity test. CONCLUSION The software we developed facilitates the immediate availability of measurement results, phantom images, and DICOM header data in all reference centers. This allows both targeted guidance and short response time in the case of errors. We achieved a consistent IT-based evaluation with standardized tools for the entire screening program in Germany.
BMJ Open | 2018
Stefanie Weigel; Joachim Gerss; Hans-Werner Hense; Miriam Krischke; A Sommer; Jörg Czwoydzinski; Horst Lenzen; Laura Kerschke; Karin Spieker; Stefanie Dickmaenken; Sonja Baier; Marc Urban; Gerold Hecht; Oliver Heidinger; Joachim Kieschke; Walter Heindel
Introduction Development of digital breast tomosynthesis (DBT) provides a technology that generates three-dimensional data sets, thus reducing the pitfalls of overlapping breast tissue. Observational studies suggest that the combination of two-dimensional (2D) digital mammography and DBT increases diagnostic accuracy. However, because of duplicate exposure, this comes at the cost of an augmented radiation dose. This undesired adverse impact can be avoided by using synthesised 2D images reconstructed from the DBT data (s2D). We designed a diagnostic superiority trial on a high level of evidence with the aim of providing a comparison of screening efficacy parameters resulting from DBT+s2D versus the current screening standard 2D full-field digital mammography (FFDM) in a multicentre and multivendor setting on the basis of the quality-controlled, population-based, biennial mammography screening programme in Germany. Methods and analysis 80 000 women in the eligible age 50–69 years attending the routine mammography screening programme and willing to participate in the TOSYMA trial will be assigned by 1:1 randomisation to either the intervention arm (DBT+s2D) or the control arm (FFDM) during a 12-month recruitment period in screening units of North Rhine-Westphalia and Lower Saxony. State cancer registries will provide the follow-up of interval cancers. Primary endpoints are the detection rate of invasive breast cancers at screening examination and the cumulative incidence of interval cancers in the 2 years after a negative examination. Secondary endpoints are the detection rate of ductal carcinoma in situ and of tumour size T1, the recall rate for assessment, the positive predictive value of recall and the cumulative 12-month incidence of interval cancers. An adaptive statistical design with one interim analysis provides the option to modify the design. Ethics and dissemination This protocol has been approved by the local medical ethical committee (2016-132-f-S). Results will be submitted to international peer-reviewed journals. Trial registration NCT03377036; Pre-results.