Howard Maibach

Multiple parameter assessment of vulvar irritant contact dermatitis

Transepidermal water loss (TEWL), capacitance, pH, blood flow and color reflectance were evaluated for quantifying the irritant response of vulvar and forearm skin to 3% sodium lauryl sulfate in 9 healthy premenopausal women. TEWL, capacitance, pH, blood flow, and all parameters of color reflectance changed significantly in forearm irritant dermatitis. In vulvar irritant dermatitis, however, significant changes were observed only for blond flow and the color reflectance parameters a* and b*. Using the combination of TEWL, capacitance and blood flow, forearm irritant dermatitis was detected with a sensitivity of 84% and a specificity of 100%. In this study, the best combination of parameters to detect vulvar irritant dermatitis was pH, blood flow. a* and b*, which had a sensitivity of 78% and a specificity of 75%. It is concluded that available bioengineering techniques are less suitable to quantify irritant dermatitis in the vulva than in the forearm.

Management of Positive Patch Test Reactions

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Contents Vol. 21, 2008

N. Ahmad, Madison, Wisc. P. Altmeyer, Bochum C. Antoniou, Athens H. Bachelez, Paris J.M. Baron, Aachen E. Benfeldt, Copenhagen E. Berardesca, Rome D.R. Bickers, New York, N.Y. J.E. Birnbaum, East Hanover, N.J. K. de Paepe, Brussels P. Elsner, Jena A. Farkas, Szeged A. Giannetti, Modena M.W. Greaves, Kuala Lumpur R. Guy, Bath J. Hadgraft , Chatham Maritime B.M. Henz, Berlin E.M. Jackson, Sumner, Wash. Y. Kawakubo, Saitama H.-C. Korting, Munich J. Krutmann, Düsseldorf R. Neubert, Halle D. Roop, Houston, Tex. T. Ruzicka, Munich M. Schäfer-Korting, Berlin S. Seidenari, Modena B. Shroot, San Antonio, Tex. J. Wohlrab, Halle S. Yamamoto, Hiroshima Journal of Pharmacological and Biophysical Research

Acknowledgments to Reviewers

Accessible online at: http://BioMedNet.com/karger 381 The editor wishes to acknowledge with sincere appreciation the assisstance of the many reviewers who have generoulsy contributed their time and efforts during 1998 in the appraisal of manuscripts submitted to Skin Pharmacology and Applied Skin Physiology. These reviewers not only have been of inestimable help in assessing the merit of original research articles but also, by their careful analysis and critique and their general and specific constructive recommendations, have often greatly enhanced the value of these manuscripts. The quality of the journal can be attributed in large measure to the quality of their effort. We are sincerely grateful.