Howard V. Dubin

Failure of reticular erythematous mucinosis to respond to cyclosporine

We describe a 48-year-old woman who had worsening psoriasis, photosensitive reticular erythematous mucinosis (REM), and acne rosacea. The psoriasis was unresponsive to etretinate, and the REM was unsuccessfully treated with hydroxychloroquine. Cyclosporine (6 mg/kg/day) successfully cleared the psoriasis in 8 weeks but did not improve the REM and acne rosacea. Possible causes for the lack of response of the REM to cyclosporine are discussed.

Nodular cutaneous B-cell lymphoma of the scalp in the acquired immunodeficiency syndrome

Aggressive B-cell non-Hodgkins lymphoma frequently complicates human immunodeficiency virus type 1 infection. Although extranodal disease is an important feature of this condition, the incidence of cutaneous involvement has not been determined. A review of 754 published cases of B-cell non-Hodgkins lymphoma associated with human immunodeficiency virus type 1 revealed an incidence of cutaneous extranodal involvement of 8.2%, approximately equal to that seen in non-Hodgkins lymphoma not associated with human immunodeficiency virus. Lymphoma was the initial manifestation of acquired immunodeficiency syndrome in two thirds of these cases. In particular, although the head and neck are commonly involved in non-Hodgkins lymphoma not associated with human immunodeficiency virus, scalp involvement is uncommon in human immunodeficiency virus-associated B-cell non-Hodgkins lymphoma, and we report the second case. The natural history and proposed pathogenesis of human immunodeficiency virus-associated non-Hodgkins lymphoma are discussed.

Diagnosis of Sézary syndrome in a patient with generalized pruritus based on early molecular study and flow cytometry

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Azaribine in the Treatment of Psoriasis

Excerpt To the editor: In the December 1970 issue of the ANNALSVogler and Olansky (1) presented a double-blind study of azaribine (6-azauridine triacetate) in the treatment of psoriasis. They showe...