Hristina Vlajinac

Prevalence of menstrually related migraine and nonmigraine primary headache in female students of Belgrade University.

Objectives.—To determine prevalence and characteristics of menstrually related migraine and nonmigraine headache in female students of Belgrade University.

Risk factors for Peyronie's disease: a case-control study

To test some hypotheses about risk factors for Peyronies disease (PD).

Behavioural and Social Characteristics of Subjects with Repeated Sexually Transmitted Diseases

A case-control study was performed in order to assess risk factors for repeated sexually transmitted diseases. The study comprised 101 patients who had had sexually transmitted diseases 3 or more times during their lives and 182 controls who had no history of sexually transmitted disease. The subjects all attended the City Department for Skin and Venereal Diseases in Belgrade, Yugoslavia, from June 1997 to April 1998. According to multivariate logistic regression analysis, sexually transmitted diseases repeaters, in comparison with the controls, were older, more frequently divorced and widowed and without a regular partner, had more sexual partners and more sexual intercourse, and had more frequent sexual contact with people on the same day as meeting them. They also consumed alcohol, used sedatives and were prosecuted for criminal offences more frequently than the controls. The results of this study support the hypothesis that sexually transmitted diseases repeaters are different from their controls in terms of their behavioural and social characteristics.

Relationship between peripheral arterial disease and metabolic syndrome.

The aim of the study was to estimate the prevalence of metabolic syndrome among 388 patients with peripheral arterial disease, to determine the relationship between the number of metabolic syndrome components (metabolic syndrome score) and the degree of established and some of the emerging vascular risk factors, and to estimate whether there was any relationship of metabolic syndrome score and other vascular risk factors with the severity of peripheral arterial disease clinical manifestations. Metabolic syndrome was present in 59.8% of the patients with peripheral arterial disease. All metabolic syndrome components were significantly related to metabolic syndrome score. The same was true for the body weight, body mass index, percentage of body fat, total cholesterol/high-density lipoprotein cholesterol ratio, uric acid, and percentage of patients with high-sensitivity C-reactive protein. The metabolic syndrome score was also significantly, but inversely, related to high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and smoking. The degree of peripheral arterial disease clinical manifestations was not related to metabolic syndrome score, but gangrene was significantly positively associated with increased fasting glucose, high-sensitivity C-reactive protein, and lower education.

Influence of socio-economic and other factors on rheumatic fever occurrence.

Conditional logistic regression analysis of case-control study data showed that the following factors were significantly related to rheumatic fever occurrence: home dampness, change of place of residence during the last 5 years, low education of mother, body weight below normal, frequent sore throat and positive family history of rheumatic fever.

Health-related quality of life among patients with peripheral arterial disease.

We evaluated health-related quality of life (HRQoL) among patients with peripheral arterial disease (PAD) and compared the results with those of the general population. We also evaluated the possible association between some demographic and clinical characteristics of patients with PAD and HRQoL. A cross-sectional study involved 102 consecutive patients with verified PAD referred to the Dedinje Vascular Surgery Clinic in Belgrade. The HRQoL was measured using Medical Outcome Survey Short Form 36 (SF-36). Patients with PAD had significantly lower mean SF-36 scores for physical functioning, role-physical, bodily pain, social functioning, role-emotional, and mental health in comparison with the general population. The HRQoL was significantly more impaired in patients with severe PAD. Patients with PAD had a reduced HRQoL compared with the general population. The impact of PAD on HRQoL was independent of other factors related to both the disease and the HRQoL.

Mortality trends of malignant tumours of digestive organs in Belgrade, Yugoslavia, 1975–1997

AIM To analyse mortality trends of malignant digestive tract tumours. MATERIAL AND METHODS Population of Belgrade (Yugoslavia) in the period 1975-1997. Mortality rates were standardized by direct method using world population as the standard. For time series, exponential trends were calculated by the use of three-year moving average rates. RESULTS In males, the highest mortality rate was for stomach cancer: 14. 6 per 100,000 (average for the period 1975-1997), followed by cancer of liver and cancer of colon: 8.4/100,000, cancer of rectum: 8.1/100,000, cancer of pancreas: 7.3/100,000, oesophageal cancer: 2.8/100,000 and gallbladder cancer: 2.0/100,000. In males, upward mortality trends for carcinomas of colon, rectum, pancreas, oesophagus, gallbladder and bile ducts were observed. The mortality rates series for stomach cancer and liver cancer did not fit any usual trend function. In females, the highest mortality rate was also for stomach cancer 7.7 per 100,000, then for cancer of colon: 6.0/100,000, cancer of rectum: 5.3/100,000, cancer of liver: 4.4/100,000, cancer of pancreas: 4.4/100,000, gallbladder cancer 3.4/100,000 and oesophageal cancer: 0.8/100,000. In females, upward mortality trends were observed for colon and rectal cancer, cancer of pancreas, and gallbladder and bile duct cancer. Downward mortality trends were present for stomach cancer and liver cancer. Mortality rates series for oesophageal cancer did not fit any usual trend function. CONCLUSIONS In the majority of digestive tracts cancers, an upward mortality trend was observed which is in keeping with the mortality trends of these malignant tumours in many other countries.

Risk factors for chronic venous disease.

Objective Chronic venous disease (CVD) is a common problem in developing and developed countries. Methods A cross-sectional study, conducted in two major towns in Serbia, comprised 3225 subjects over 18 years old, enrolled in the survey consecutively by general practitioners (GPs) within their normal framework. Diagnosis of CVD was made by GPs on the basis of symptoms and visual examination. Data on potential risk factors were collected by the use of a questionnaire. Results The prevalence of CVD was significantly higher in women (73.7%) than in men (70.1%), although severe forms of CVD were significantly more frequent in men. Risk factors for CVD were age, body mass index ≥25.00 kg/m2, family history of CVD, history of blood clots in veins and ever-smoking in both sexes, and menopause, increased number of child births and physical inactivity in women. Conclusion The results obtained suggest the possibility of CVD prevention by modification of some behavioural risk factors.

SOME LIFESTYLE HABITS OF FEMALE BELGRADE UNIVERSITY STUDENTS WITH MIGRAINE AND NON-MIGRAINE PRIMARY HEADACHE

AbstractWe performed a prevalence study to compare some lifestyle habits between subjects with migraine and those with nonmigraine primary headaches. We surveyed female students in randomly selected classes of the School of Medicine and the School of Pharmacy, Belgrade University. Among all observed students (1943 subjects), 245 had migraine and 1053 had non-migraine primary headache. According to multivariate logistic regression analysis, the following factors were associated with migraine: irregular eating (odds ratio (OR)=1.99; 95% confidence interval (95% CI), 1.69 to 2.34; p<0.01), sleep duration shorter than usual (OR=1.18; 95% CI 1.00 to 1.38; p=0.0449) and smoking >10 cigarettes per day (OR=1.18; 95% CI=1.00 to 1.39; p=0.0433). The results of the present study are in line with some other investigations suggesting that some lifestyle habits probably play a role as migraine precipitants.

The belgrade childhood diabetes study: association of infections and vaccinations on diabetes in childhood

PURPOSE The aim of this study was to investigate whether individual infections or combination of infections or vaccination affect the risk of developing diabetes in childhood. METHODS A case-control study was conducted in Belgrade during the period between 1994 and 1997. A total of 105 recent onset diabetics were compared with 210 controls chosen among children with skin disease (the first control group). Cases and controls were individually matched by age (+/-1 year), sex, and place of residence. Eighty-six diabetic children were also compared with their brothers/sisters (the second control group). RESULTS After adjustment for confounding variables, independent association with diabetes was found for infections during the 6 months preceding the onset of the disease, when cases were compared with both the first control group (OR=4.23, 95% CI, 1.95-9.17, p<0.001) and the second control group (OR=4.68, 95% CI, 2.09-10.47, p<0.001), and for regular vaccination when cases were compared with the first control group (OR=0.08, 95% CI, 0.01-0.50, p=0.03). CONCLUSION The results obtained support the hypotheses that infections play a role in the development of type 1 diabetes and that regular vaccination has a preventive effect.