Huang By
Chang Gung University
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Publication
Featured researches published by Huang By.
Journal of Clinical Pathology | 1997
Hung Yu Chang; Jen Der Lin; Jung Fu Chen; Huang By; Chuen Hsueh; Long Bin Jeng; Jir Shiong Tsai
AIMS: To evaluate the correlation of fine needle aspiration (FNA) cytology and frozen section biopsy in the diagnosis of thyroid nodules. METHODS: The medical records of 662 patients who underwent FNA cytology of the thyroid and thyroid surgery were analysed. Frozen section biopsies were taken from 586 of the 662 patients. The diagnostic correlations of FNA cytology, frozen section, and both FNA cytology and frozen section with definitive histological assessment were evaluated. RESULTS: Among the 662 patients who received FNA cytology, there were 356 cases (53.8%) diagnosed as benign, 114 cases (17.2%) as malignant, 148 cases (22.4%) as indeterminate, and 44 cases (6.6%) as unsatisfactory. The positive predictive value for the detection of malignancy by FNA cytology was 92.1% and the negative predictive value was 95.2%. The incidence of malignancy in the indeterminate cytological diagnosis was 23%. The diagnosis from frozen sections was benign in 445 cases (75.9%), malignant in 134 cases (22.9%), and deferred in 7 cases (1.2%). By frozen section, the positive and negative predictive values were 97% and 95.5%, respectively. Diagnostic accuracy up to 98% was achieved when FNA cytology and frozen section diagnoses were in agreement. No false positives were observed when FNA cytology and frozen sections were both positive for malignancy. When FNA cytology and frozen section diagnoses were discordant, frozen section showed a higher accuracy (78.9%) than FNA cytology (21.1%). In the face of an indeterminate or unsatisfactory cytological diagnosis, the diagnostic accuracy of frozen sections reached 92.6%. CONCLUSIONS: The results confirm that FNA cytology is a useful tool in the initial evaluation of thyroid nodules. Intraoperative frozen section is a valuable procedure to confirm the cytological diagnosis and identify malignancy in patients with indeterminate or unsatisfactory cytological diagnosis. With reliance on frozen sections as an intraoperative guide of thyroid surgery, the possibility of unnecessary extensive surgery and the need for the second operation are considerably lower.
Journal of Clinical Ultrasound | 1997
Jen Der Lin; Huang By; Hsiao Fen Weng; Long Bin Jeng; Chuen Hsueh
This series retrospectively reviewed 3657 patients who received thyroid ultrasonography with fine‐needle aspiration cytological (FNAC) examinations at Chang Gung Memorial Hospital during the period from January 1, 1993 to December 31, 1993. Thyroid ultrasonography studies were performed using a real‐time ultrasonographic machine with a 10 MHz transducer. The aspirates were air dried and stained by the Romanowsky‐based Liu method. Three hundred seventy‐eight cases (10.3%) received surgical treatment after the ultrasonographic and FNAC examinations. Benign lesions were diagnosed in 269 patients. Thyroid malignancy was confirmed histopathologically in 109 cases including 76 papillary thyroid carcinomas, 17 follicular carcinomas, 5 medullary thyroid carcinomas, 3 anaplastic carcinomas, 3 Hürthle cell carcinomas, and 3 lymphomas. Another 2 cases were metastatic cancer to thyroid. The results demonstrated that 28.8% of the surgically treated patients had histopathologically proven malignancies. The incidence of thyroid malignancy was 2.98% in this study. The sensitivity of the cytological diagnosis was 79.80% and the specificity was 98.66%. The positive predictive value was 96.34%. Negative predictive value was 91.70%. The false negative index was 20.20%. The diagnostic accuracy was 92.89%. Thyroid ultrasonography with the FNAC can provide high specificity and sensitivity in differentiating malignant lesions from benign.
Chang Gung medical journal | 2011
Lin Jd; Chuen Hsueh; Huang By
Chang Gung medical journal | 1990
Chen Ch; Huang Mj; Huang By; Liu Rt; Jyuhn-Huarng Juang; Lin Jd; Huang Hs
Journal of the Formosan Medical Association | 1988
Huang Hs; Huang Mj; Huang Cc; Huang By; Wang Pw; Lin Jd
Chang Gung medical journal | 1993
Lin Jd; Huang By; Huang Hs; Jyuhn-Huarng Juang; Long Bin Jeng
Chang Gung medical journal | 1991
Li Kl; Huang Hs; Po-Nan Wang; Lin Jd; Jyuhn-Huarng Juang; Liu Rt; Huang By; Huang Mj
Chang Gung medical journal | 1990
Chen Jy; Huang Hs; Huang Mj; Lin Jd; Jyuhn-Huarng Juang; Huang By; Po-Nan Wang; Liu Rt
Chang Gung medical journal | 1999
Ng Sc; Lin Jd; Huang By; Chen Ch; Chuen Hsueh; Lee N; Tzu-Chen Yen
Chang Gung medical journal | 1996
Ho C; Lin Jd; Huang Yy; Huang Hs; Huang By; Chuen Hsueh