Hugo C. Moeller

Effect of Lipemia and Heparin on Free Fatty Acid Content of Rat Plasma.

Summary Injection of heparin produces a moderate rise in the free fatty acid content of the plasma of fasted rats and a marked rise in lipemic rats. In the latter case this is accompanied by a precipitous fall in total fatty acid content. A moderate rise in free fatty acid content also occurs in association with lipemia without heparin injection.

Toxicity of parathion, systox, octamethyl pyrophosphoramide, and methyl parathion in man☆

Abstract Experiments in human beings were undertaken to determine the levels of minimal toxicity of parathion, systox, OMPA, and methyl parathion. The study of parathion demonstrated that the level of minimal toxicity is 7.5 mg per day. Between 6.75 and 7.125 mg per day of systox produced minimal toxicity. In the case of OMPA the level of minimal toxicity was 1.5 mg per day. This compound is of further interest in that it was the only compound studied to which the red cell cholinesterase activity was more sensitive than the plasma cholinesterase activity. Although doses as high as 19.0 mg per day were evaluated in the study of methyl parathion, the level of minimal toxicity was not established.

Effect of lipemia and heparin on free fatty acid concentration of serum in humans.

Summary 1. During alimentary lipemia and lipemia produced by intravenous injection of fat emulsions there was a rise in the concentration of free fatty acid in serum. The free fatty acid was found in the non-turbid portion of serum (infranatant of high speed centrifugation). Injection of heparin produced an elevation of free fatty acid concentration which was greater in lipemic than in fasting subjects. A portion of this elevation after heparin was attributable to in vitro lipolysis. 2. It is suggested that lipolysis with free fatty acid formation may play a role in normal fat metabolism and transport.

Gastric Glomus Tumor: Report of Case and Review of Literature

Summary The eighth instance of gastric glomus tumor is reported. Review of the literature discloses an apparent propensity of these tumors to occur in men over 40 and to be associated with upper gastrointestinal bleeding.

Lack of Effect of Crystalline Lysozyme on the Isolated Intestinal Pouch of the Dog

Summary Lysozyme in high concentrations does not demonstrably alter the mucous membrane of the ileo-colic pouch of the dog even after exposure to the enzyme over a prolonged period of time.

Lysozyme Production in Response to Injury of Gastrointestinal Tract in Dogs

Summary 1. Lysozyme is produced in moderately large amounts by the gastrointestinal tract of dogs subjected to chronic stimulation with Mecholyl. The increase in lysozyme is demonstrable in the bloody diarrheal stools of intact animals and in material aspirated from isolated pouches of colon. 2. Cautery of canine rectum stimulates the local production of large amounts of lysozyme within 5 1/2 hours after injury. 3. The rapid production of lysozyme by injured bowel suggests that it is an early accompaniment of the inflammatory reaction and that its presence is a reflection rather than a cause of ulcerative alimentary disease.

Colorimetric Measurement of Serum Cholinesterase

Summary The colorimetric esterase method of Gomori(5) was applied to studies on the cholinesterase activity of serum. The method was found to be applicable to studies on the action of anticholinesterase agents in vitro. It is also suitable for detecting exposure of humans to organic phosphorus-containing insecticides and for following serum cholinesterase levels during therapy with anticholinesterase drugs.