Hugo Muench

Estimation of Liver Size by Percussion in Normal Individuals

Abstract Estimation of liver size by percussion was determined in 116 normal subjects by three examiners. Factors responsible for variation in percussion measurement within and between examiners we...

A Controlled Trial of Prophylactic Portacaval-Shunt Surgery

PATIENTS with cirrhosis and varices often die after esophageal hemorrhage. In a retrospective analysis of the records of 106 patients appearing in the years 1918–1938 only 30 per cent survived for ...

Evaluation of Drug Efficacy by a Preference Technic

INCREASED awareness of the importance of properly controlled drug evaluations has brought with it a need for the development of experimental technics that can provide essential information about dr...

Comparative trial of chemotherapy and radiotherapy in patients with non-resectable cancer of the lung☆

Abstract Two hundred and nineteen patients with carcinoma of the lung were studied in three treatment groups in a cooperative in-hospital study. Of these patients, 196 had not received prior therapy. Treatment group I was given a mean of 3,843 tissue r., treatment group II a mean of 37.8 mg. of nitrogen mustard therapy and 3,658 tissue r. simultaneously and treatment group III 41.0 mg. nitrogen mustard therapy followed by 3,633 tissue r. In evaluating shrinkage in tumor size, benefits as determined by votes of the investigators and over-all survival curves, essentially no beneficial differences emerged for any one treatment group. Toxicity was slightly greater in group II, and treatment time extended for these same patients. No difference in toxicity or survival time appeared between 250 kv. or 2 Mev radiotherapy equipment. Data and discussion are presented to indicate that in this study survival time is independent of the form of treatment administered but that natural selection alone determines the patients with longer survivorship. The routine use of radiotherapy and mechlorethamine treatment, therefore, is questioned.

Liver Function in Diabetes Mellitus

MANY reports have been published regarding the outcome of liver-function tests both in healthy persons and in those with pathologic states. The data have shown considerable variation from one study...