Hui-ping Zhang

CONVOLUTAMYDINE A, A NOVEL BIOACTIVE HYDROXYOXINDOLE ALKALOID FROM MARINE BRYOZOAN AMATHIA CONVOLUTA

Abstract Convolutamydine A ( 1 ), a new alkaloid containing a dibromohydroxyoxindole moiety, was isolated from the Floridian bryozoan Amathia convoluta and the structure was elucidated on the basis of spectroscopic data. Compound 1 exhibited a potent activity in the differentiation of HL-60 cells.

Isolation and structure of convolutamydines B ∼ D from marine bryozoan Amathia convoluta

Abstract Convolutamydines B ∼ D (2 ∼ 4), three new alkaloids containing a dibromohydroxyoxindole moiety, were isolated from the Floridian bryozoan Amathia convoluta and the structures were elucidated on the basis of spectroscopic data. Convolutamydine B (2) has been found to exhibit a biological activity in the differention of HL-60 cells.

Convolutamides A ∼ F, novel γ-lactam alkaloids from the marine bryozoan Amathia convoluta

Abstract Convolutamides A ∼ F, new alkaloids containing an N-acyl-γ-lactam moiety with a dibromophenol group, have been isolated from the Floridian bryozoan Amathia convoluta and the structures elucidated on the basis of spectroscopic data.

Conformational analysis of a marine antineoplastic macrolide, bryostatin 10☆

Abstract Conformation of bryostatin 10, a marine antineoplastic macrolide, in CDCl3 was analyzed by the spectroscopic and computational chemical methods. A combination of homonuclear two-dimensional NMR techniques at 600 MHz have enabled us to perform complete assignment of the 1H signals of bryostatin 10 in CDCl3. The conformation of its solution form was elucidated by a phase sensitive ROESY spectrum, temperature effect on OH proton and 3J vicinal coupling constants. Restrained molecular-dynamics simulation led to a well defined conformation of the compound in solution, which was found to be homologous to that of bryostatin 2 observed in the solid state.