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Dive into the research topics where Hui-Ting Chen is active.

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Featured researches published by Hui-Ting Chen.


Chemical Communications | 2013

Concise solid-phase synthesis of inverse poly(amidoamine) dendrons using AB2 building blocks

Adela Ya-Ting Huang; Ching-Hua Tsai; Hsing-Yin Chen; Hui-Ting Chen; Chi-Yu Lu; Yu-Ting Lin; Chai-Lin Kao

A concise solid-phase synthesis of inverse poly(amidoamine) dendrons was developed. Upon introduction of AB2-type monomers, each dendron generation was constructed via one reaction. G2 to G5 dendrons were constructed in a peptide synthesizer in 93%, 89%, 82%, and 78% yields, respectively, within 5 days.


Macromolecular Rapid Communications | 2017

Solid-Phase Synthesis of a Seventh-Generation Inverse Poly(amidoamine) Dendrimer: Importance of the Loading Ratio on the Resin

Chai-Lin Kao; Adela Ya-Ting Huang; Hui-Ting Chen

Here, this study overcomes the current barriers to efficient solid-phase synthesis of high-generation dendrimers by decreasing the loading ratio on the resin. G7 inverse poly(amidoamine) dendrimer is now prepared, for the first time, through a solid-phase synthesis using only 50% of the available reactive sites and by choosing a large resin. This preparation takes only 15 d to afford highly pure product in 80% yield with precipitation being the only purification procedure used. The results clearly show the amount of the initial monomer loaded on the resin to be a vital factor for the ability to use solid-phase synthesis to produce large dendrimers. This finding also sets stage for the applications of solid-phase synthesis for the preparation of other macromolecules.


Journal of the American Chemical Society | 2004

Cytotoxicity, hemolysis, and acute in vivo toxicity of dendrimers based on melamine, candidate vehicles for drug delivery.

Hui-Ting Chen; Michael F. Neerman; Alan R. Parrish; Eric E. Simanek


Molecular Pharmaceutics | 2004

Reduction of drug toxicity using dendrimers based on melamine.

Michael F. Neerman; Hui-Ting Chen; and Alan R. Parrish; Eric E. Simanek


Nanomedicine: Nanotechnology, Biology and Medicine | 2011

Copper complex of a pyridine-modified poly(amidoamine) dendrimer as a chemical nuclease: synthetic and catalytic study

Chai-Lin Kao; Yi-Hsuan Tang; Yen Chung Lin; Li-Ting Chiu; Hui-Ting Chen; Sodio C. N. Hsu; Kuang-Chan Hsieh; Chi-Yu Lu; Yeh-Long Chen


Advanced Synthesis & Catalysis | 2015

Aryl λ3-Iodane-Mediated 6-exo-trig Cyclization to Synthesize Highly Substituted Chiral Morpholines

Jaya Kishore Vandavasi; Wan-Ping Hu; Gopal Chandru Senadi; Hui-Ting Chen; Hsing-Yin Chen; Kuang-Chan Hsieh; Jeh-Jeng Wang


Chemical Communications | 2018

A selective glucose sensor: the cooperative effect of monoboronic acid-modified poly(amidoamine) dendrimers

Ching-Hua Tsai; Yi-Hsuan Tang; Hui-Ting Chen; Yi-Wen Yao; Tun-Cheng Chien; Chai-Lin Kao


Canadian Journal of Chemistry | 2017

Accelerated hydrolysis of boronic acid in a modified poly(amidoamine) dendrimer: identification of a factor leading to the production of an impurity in boronic acid-containing PAMAM dendrimers

Ching-Hua Tsai; Yu-Wen Fang; Hui-Ting Chen; Chai-Lin Kao


Asian Journal of Organic Chemistry | 2016

Solid‐phase Synthesis of Libraries of Triazine Dendrimers and Orthogonal Staining Methods for Tracking Reactions on Resin

Adela Y.‐T. Huang; Subrata Patra; Hui-Ting Chen; Chai-Lin Kao; Eric E. Simanek


Chemical Science | 2018

Expedient on-resin modification of a peptide C-terminus through a benzotriazole linker

Anand Selvaraj; Hui-Ting Chen; Adela Ya-Ting Huang; Chai-Lin Kao

Collaboration


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Chai-Lin Kao

Kaohsiung Medical University

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Adela Ya-Ting Huang

Kaohsiung Medical University

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Ching-Hua Tsai

Kaohsiung Medical University

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Yi-Hsuan Tang

Kaohsiung Medical University

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Eric E. Simanek

Texas Christian University

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Chi-Yu Lu

Kaohsiung Medical University

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Hsing-Yin Chen

Kaohsiung Medical University

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Kuang-Chan Hsieh

Kaohsiung Medical University

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Adela Y.‐T. Huang

Kaohsiung Medical University

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