Hülya Gürbüz
Trakya University
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Publication
Featured researches published by Hülya Gürbüz.
Clinical and Experimental Hypertension | 2010
Mehmet Kanter; Hülya Gürbüz; Tulay Kilic Okman
Our objective was to investigate the endothelial nitric oxide synthase (eNOS) immuno-reactivity and the ultrastructure of endothelial cells of a human umbilical artery in both normal and preeclamptic pregnancies. The umbilical cords from normal and preeclamptic pregnancies were collected immediately after vaginal and abdominal deliveries. Umbilical arteries were isolated and fixed in 10% neutral formaline solution, embedded in paraffin, and then stained with hematoxylin and eosin (H&E) for the histologic investigation, and eNOS activation were examined in samples by streptavidine-biotine immunohistochemical methods. The arterial sections were also fixed in phosphate-buffered 2.5% glutaraldehyde solution (pH 7.2) for 3 h and post-fixed with 1% osmium tetroxide at 4°C for 2 h for the investigation of the ultrastructural examination. In the umbilical artery of preeclamptic pregnancies, endothelial cells were oval, triangular, or polygonal, and were disorganized. Some endothelial cells were separated by enlarged intercellular spaces. A dilated endoplasmic reticulum, swollen mitochondria, and vanished mitochondrial cristae were observed. The nuclei of some endothelial cells displayed deep invaginations and irregular outlines. Most endothelial cells had a high number of cytoplasmic vacuoles. In preeclampsia, eNOS immunoreactivity increased considerably in endothelial cells when compared to normal pregnancies. We believe that preeclampsia plays an important role in the pathogenesis of endothelial cell dysfunction and activation in the umbilical artery. However, the disturbance mechanism of endothelial cells is not known, and further studies are necessary to clarify the exact mechanism.
Saudi Medical Journal | 2006
Hülya Gürbüz; Osman U. Calpur; Mert Özcan; Tunc Kutoglu; Recep Mesut
Clinical Anatomy | 2005
Bulent Yalcin; Tunc Kutoglu; Hasan Ozan; Hülya Gürbüz
Turkiye Klinikleri Journal of Medical Ethics-Law and History | 2004
Hülya Gürbüz; Esin Karlikaya; Recep Mesut
Balkan Medical Journal | 2014
Ali Yılmaz; Oğuz Taşkınalp; Hülya Gürbüz
Archive | 2007
Hülya Gürbüz; Tunç Kuto; Recep Mesut; Mert Özcan
Balkan Medical Journal | 2007
Hülya Gürbüz; Tunç Kutoğlu; Recep Mesut; Osman U. Calpur; Mert Özcan
Archive | 2005
Tunc Kutoglu; Enis Ulucam; Hülya Gürbüz
Balkan Medical Journal | 2005
Ali Yılmaz; Oğuz Taşkınalp; Hülya Gürbüz
Balkan Medical Journal | 2004
Hülya Gürbüz