Huma Dilshad

Comparative Study of Four Different Brands of Ranitidine Available in Karachi

Ranitidine is used in peptic ulcer therapy and available as several brands in the market which makes it difficult to select the safe, effective and economic one. The aim of this study is to establish similarity among the different brands of ranitidine HCl tablets available in local market of Karachi, Pakistan. Four different brands of (150 mg) were selected for the study. Six quality control parameters: weight variation test, hardness test, thickness, friability, disintegration test and dissolution test were carried out specified by USP. Result revealed that all brands comply within limits for hardness, weight variation, thickness, friability, disintegration and dissolution. Disintegration time for all brands was within 15 minutes complying with the USP commendation. All brands showed Q-value more than 80% within 45 minutes. The present findings suggest that almost all the brands of ranitidine HCl that are available in Karachi meet the USP specification for quality control analysis and are interchangeable.

FORMULATIONS OF ISOSORBIDE MONONITRATE (ISMN) TABLET AND COMPARATIVE STUDY WITH AVAILABLE BRAND S

In the present study new formulations of Isosorbide mono nitrate were ma nufactured by dry granulation method using Talc instead of magnesium stearate and compared with different brands o f isosorbide mono nitrate ta blets available in the market. The present study is divided into two phases. For the first phase new formulation of Isosorbide mono nitrate was prepared by dry granulat ion method and during manufacturing magnesium stearate was rep laced by Talc as it is cheaper, less process dependant and requires less blending time as compared to magnesium stearate. Mixing time differences of as little as two minutes can significantly alter the dissolution pattern of finished tablets. In the 2 nd ph ase of present study three different brands of isosorbide dinitrate tablets were randomly selected from the local market using probability sampling tools and evaluated for weight variation test , friability test and hardness test . Disintegration was also co nducted according to the methods and guidelines given in BP/USP. The res ults showed that all parameters like weight - variation, disintegration, hardness, thickness and friability of new formulations are in accordance with the BP/USP limits and the new formu lation containing talc showed better potency as c ompared to other market brands. The most obvious advantage of replacement of magnesium stearate by t alc is its better economy, resulting to reduce processing time, less equipment and space required less proc ess validation and lower energy utilization with equal potency and safety.