Hüseyin Güvenç

Omphalitis in term and preterm appropriate for gestational age and small for gestational age infants

To determine whether there is a difference on the historical and clinical characteristics of omphalitis among term and preterm appropriate for gestational age (AGA) and small for gestational age (SGA) infants, we prospectively investigated 85 newborns with bacteriologically proved omphalitis. Study groups were based on gestational age and being SGA. Preterm AGA infants had significantly lower mean age and neutrophil counts. Risk factors such as septic delivery including unplanned home delivery, and bacterial spectrum were similar in the groups. Staphylococcus aureus and Escherichia coli were the most frequent micro-organisms. Mortality rates for the study groups were similar and overall case fatality rate was 13 per cent. Immunological immaturity of preterm newborns may explain the earlier occurrence age of omphalitis and lower absolute neutrophil count. The following features such as early-onset infection, septic delivery including unplanned home delivery and abnormal temperature may be considered as determinants of poor prognosis. However, further studies are needed.

Brucellosis in a Child Complicated with Multiple Brain Abscesses

A 4-year-old boy developed symptoms consistent with brucellosis and was treated with combined streptomycin and tetracycline. He had a high brucella agglutinin titer. However, he continued to have headache and papilledema. A brain CT revealed 6 large abscesses. Brucella melitensis was isolated from abscess material. The boy recovered completely after drainage therapy.

Neonatal omphalitis is still common in eastern turkey

88 newborns with omphalitis diagnosed at a University Hospital in Eastern Turkey from January 1988 to December 1990 were reviewed. The yearly incidence was 7.7% in inpatient newborns. Risk factors including septic delivery (especially home delivery), prematurity, and being small for gestational age appeared to be important. Clinical manifestations, white blood cell and absolute neutrophil counts were non-specific and non-pathognomonic. Bacteriologic analysis revealed that Gram-positive bacteria (68%) predominated over Gram-negative isolates (60%). Staphylococcus aureus and Escherichia coli were the most frequent microorganisms. Mortality rate was 15%; all deaths occurred in patients presenting with systemic symptoms. The following poor prognostic factors were identified: septic delivery (particularly at home), prematurity, being small for gestational age and the development of systemic symptoms.

Prune-belly syndrome associated with omphalocele in a female newborn.

The authors report on a female newborn with prune-belly syndrome (PBS) in association with omphalocele. This case raises the total of omphalocele associated with PBS to seven. The authors suggest that this case lends support to the concept of PBS being caused by an early disturbance of mesodermal development in both the abdominal wall and the urinary tract.

Comparison of Children and Adults with Tuberculous Meningitis in Elazig, Turkey

Retrospective evaluation of 16 cases of tuberculous meningitis revealed that BCG vaccination and tuberculin positivity were rare in pediatric as well as adult patients. Children with disease had developmental retardation and a high rate of maternal illiteracy as compared to normal controls.

Serum gonadotropins and estradiol levels in Turkish pubertal girls.

Serum follicle stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E2) levels were measured by radioimmunoassay in the sera of 37 healthy Turkish pubertal girls. The data show that FSH levels significantly increased from stage 2 to 3, and tented to plateau during stages 3,4 and 5, and LH and estradiol levels constantly rises with advances in sexual development and significantly correlates with pubertal stages. When the serum FSH level was compared in pre and postmenarcheal girls of the same age the level was almost identical. Adversely, LH and estradiol levels were higher in postmenarcheal girls than in premenarcheal girls.

Fırat Üniversitesi Araştırma Hastanesi nde 1993 1994 Yıllarında Doğan Bebeklerde Konjenital Malformasyon Sıklığı Dağılımı ve Risk Faktörlerinin Araştırılması

Haziran 1993 Haziran 1994 yillari arasinda hastanemizde 20 gebelik haftasi ve sonrasi dogum agirligi 500 gram ve uzeri agirlikta olan canli olu ve dusuk olarak dogan tum bebekler prospektif bir calisma ile konjenital anomali yonunden incelendi Bu donemde dogan 733 bebekten 38 5 2 inde konjenital malformasyon saptandi Olgularda major anomali 4 0 minor anomali 1 6 tekil anomali 4 3 4 ve cogul anomali ise 0 8 oraninda saptandi En yuksek oranda anomali bas boyun sisteminde 1 5 kas iskelet sisteminde 1 1 ve merkezi sinir sisteminde 1 0 gozlendi Konjenital malformasyon sikligi dogduktan sonra erken donemde olenlerde ve olu doganlarda anne yasi 35 ve uzerinde olanlarda koyde oturanlarda ve egitim duzeyi dusuk olanlarda dogum sekli mudahaleli ve sezaryen gelis sekli makat veya diger anormal sekillerde olanlarda 1500 gramdan daha dusuk doganlarda gebelik suresi 28 haftadan kisa olanlarda ve yakin akrabalarinda anomalili bebek oykusu olanlarda istatistiksel olarak anlamli derecede yuksek bulundu Anahtar kelimeler: Yenidogan Konjenital Malformasyon