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Dive into the research topics where Hwa-Ying Wang is active.

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Featured researches published by Hwa-Ying Wang.


Annals of the Rheumatic Diseases | 2010

Radiographic severity of knee osteoarthritis is conditional on interleukin-1 receptor antagonist gene variations

Mukundan Attur; Hwa-Ying Wang; Virginia B. Kraus; Jack F. Bukowski; Nazneen Aziz; Svetlana Krasnokutsky; Jonathan Samuels; Jeffrey D. Greenberg; Gary McDaniel; Steven B. Abramson; Kenneth S. Kornman

Background A lack of biomarkers that identify patients at risk for severe osteoarthritis (OA) complicates development of disease-modifying OA drugs. Objective To determine whether inflammatory genetic markers could stratify patients with knee OA into high and low risk for destructive disease. Methods Genotype associations with knee OA severity were assessed in two Caucasian populations. Fifteen single nucleotide polymorphisms (SNPs) in six inflammatory genes were evaluated for association with radiographic severity and with synovial fluid mediators in a subset of the patients. Results Interleukin 1 receptor antagonist (IL1RN) SNPs (rs419598, rs315952 and rs9005) predicted Kellgren–Lawrence scores independently in each population. One IL1RN haplotype was associated with lower odds of radiographic severity (OR=0.15; 95% CI 0.065 to 0.349; p<0.0001), greater joint space width and lower synovial fluid cytokine levels. Carriage of the IL1RN haplotype influenced the age relationship with severity. Conclusion IL1RN polymorphisms reproducibly contribute to disease severity in knee OA and may be useful biomarkers for patient selection in disease-modifying OA drug trials.


Journal of Periodontal Research | 2015

Association of interleukin-1 gene variations with moderate to severe chronic periodontitis in multiple ethnicities

X. Wu; Steven Offenbacher; N. J. Lόpez; D. Chen; Hwa-Ying Wang; John J. Rogus; J. Zhou; James Beck; S. Jiang; X. Bao; Leon Wilkins; Lynn Doucette-Stamm; Kenneth S. Kornman

Background and Objective Genetic markers associated with disease are often non-functional and generally tag one or more functional “causative” variants in linkage disequilibrium. Markers may not show tight linkage to the causative variants across multiple ethnicities due to evolutionary divergence, and therefore may not be informative across different population groups. Validated markers of disease suggest causative variants exist in the gene and, if the causative variants can be identified, it is reasonable to hypothesize that such variants will be informative across diverse populations. The aim of this study was to test that hypothesis using functional Interleukin-1 (IL-1) gene variations across multiple ethnic populations to replace the non-functional markers originally associated with chronic adult periodontitis in Caucasians. Material and Methods Adult chronic periodontitis cases and controls from four ethnic groups (Caucasians, African Americans, Hispanics and Asians) were recruited in the USA, Chile and China. Genotypes of IL1B gene single nucleotide polymorphisms (SNPs), including three functional SNPs (rs16944, rs1143623, rs4848306) in the promoter and one intronic SNP (rs1143633), were determined using a single base extension method or TaqMan 5′ nuclease assay. Logistic regression and other statistical analyses were used to examine the association between moderate to severe periodontitis and IL1B gene variations, including SNPs, haplotypes and composite genotypes. Genotype patterns associated with disease in the discovery study were then evaluated in independent validation studies. Results Significant associations were identified in the discovery study, consisting of Caucasians and African Americans, between moderate to severe adult chronic periodontitis and functional variations in the IL1B gene, including a pattern of four IL1B SNPs (OR = 1.87, p < 0.0001). The association between the disease and this IL1B composite genotype pattern was validated in two additional studies consisting of Hispanics (OR = 1.95, p = 0.04) or Asians (OR = 3.27, p = 0.01). A meta-analysis of the three populations supported the association between the IL-1 genotype pattern and moderate to severe periodontitis (OR 1.95; p < 0.001). Our analysis also demonstrated that IL1B gene variations had added value to conventional risk factors in predicting chronic periodontitis. Conclusion This study validated the influence of IL-1 genetic factors on the severity of chronic periodontitis in four different ethnicities.


Journal of Periodontology | 2017

Influence of Obesity on Periodontitis Progression Is Conditional on Interleukin-1 Inflammatory Genetic Variation

Leon Wilkins; Elizabeth Krall Kaye; Hwa-Ying Wang; John J. Rogus; Lynn Doucette-Stamm; Kenneth S. Kornman; Raul I. Garcia

BACKGROUND This study evaluates whether specific patterns of interleukin (IL)-1 gene variants, known to affect periodontitis severity, influence the previously reported association between obesity and subsequent periodontitis progression in a longitudinal database. The study population included 292 men (aged 29 to 64 years at entry) from the Veterans Affairs Dental Longitudinal Study from whom DNA and dental and anthropometric endpoints were collected during multiple examinations (approximately every 3 years for up to 27 years). METHODS Key variables assessed included: 1) periodontitis; 2) body mass index; 3) waist circumference to height (WHTR) ratio for central adiposity; 4) age; 5) smoking; 6) glucose tolerance; and 7) two previously reported versions of IL-1 genetic patterns associated with periodontitis severity and progression. Disease progression was determined using predefined criteria that used a combination of change in classification of disease severity based on alveolar bone loss and tooth loss during follow-up. Extended Cox regression analyses were used to estimate hazards of experiencing periodontal disease progression with or without adjustments for appropriate covariates. RESULTS In hazard ratio analyses, men with WHTR >50% at baseline and positive for either IL-1 genotype version were at significantly higher risk (two-fold) for disease progression (P for interaction = 0.04). Participants positive for IL-1 genotype version 2 exhibited earlier progression (fewer years from baseline to first incidence of progression) than those who were negative (P = 0.02, adjusted for age and smoking). CONCLUSION In this longitudinally monitored male population, observed effect of baseline central adiposity on future periodontitis progression is conditional on proinflammatory IL-1 genetic variations.


Journal of Clinical Periodontology | 1997

The interleukin-1 genotype as a severity factor in adult periodontal disease.

Kenneth S. Kornman; Allison Crane; Hwa-Ying Wang; Francesco S.di Giovlne; Michael G. Newman; Frederick W. Pirk; Thomas G. Wilson; Frank L. Higginbottom; Gordon W. Duff


Journal of Periodontology | 2000

Interleukin-1 Genetic Association With Periodontitis in Clinical Practice

Michael J. McDevitt; Hwa-Ying Wang; Carol Knobelman; Michael G. Newman; Francesco S. di Giovine; Janice Timms; Gordon W. Duff; Kenneth S. Kornman


Journal of Periodontology | 2000

Low Prevalence of a Periodontitis-Associated Interleukin-1 Composite Genotype in Individuals of Chinese Heritage

Gary C. Armitage; Yafei Wu; Hwa-Ying Wang; Julian Sorrell; Francesco S. di Giovine; Gordon W. Duff


Journal of Orthopaedic Research | 2000

Longitudinal characterization of synovial fluid biomarkers in the canine meniscectomy model of osteoarthritis.

E. Lindhorst; Thomas P. Vail; Farshid Guilak; Hwa-Ying Wang; Lori A. Setton; Vladimir Vilim; Virginia B. Kraus


Human Genetics | 2008

IL1B gene promoter haplotype pairs predict clinical levels of interleukin-1β and C-reactive protein

John J. Rogus; James D. Beck; Steven Offenbacher; Kenneth Huttner; Licia Iacoviello; Maria Carmela Latella; Monica de Gaetano; Hwa-Ying Wang; Kenneth S. Kornman; Gordon W. Duff


Osteoarthritis and Cartilage | 2013

IL-1 receptor antagonist gene as a predictive biomarker of progression of knee osteoarthritis in a population cohort

X. Wu; V. Kondragunta; Kenneth S. Kornman; Hwa-Ying Wang; Gordon W. Duff; Jordan B. Renner; Joanne M. Jordan


Journal of the Massachusetts Dental Society | 2000

Is periodontitis genetic? The answer may be Yes!

Kenneth S. Kornman; Knobelman C; Hwa-Ying Wang

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Mukundan Attur

Beth Israel Deaconess Medical Center

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Steven B. Abramson

Beth Israel Deaconess Medical Center

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