Hwa Yong Shin
Seoul National University
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Featured researches published by Hwa Yong Shin.
Korean Journal of Anesthesiology | 2009
Ji Yoon Rho; Hwa Yong Shin; Hyun Chang Kim; Ji Won Lee; Seong Deok Kim
BACKGROUND Hypoxic pulmonary vasoconstriction (HPV) is unique to pulmonary circulation but the mechanism remains elusive. Red blood cells (RBCs) are known to augment HPV and to release more ATP as oxygen content falls. Leukotrienes constrict smooth muscle and could be important for the regulation of the pulmonary circulation. Hence we hypothesized that ATP and leukotrienes are mediators of HPV produced during acute alveolar hypoxia. METHODS In forty Sprague-Dawley rats, lungs were isolated and perfused. We administered ATP (10 micrometer) to the ATP group (n = 8), the ATP antagonist, suramin (100 micrometer) to the suramin group (n = 8), leukotriene C4 (LTC4, 5 microgram) to the LTC4 group (n = 8), the LTC4 antagonist, LY171883 (20 micrometer) to the LY171883 group (n = 8), and LTC4 (5 microgram) + ATP (10 micrometer) to the LTC4 + ATP group (n = 8) during normoxic ventilation. HPV responses were induced by three hypoxic challenges for 5 minutes separated by 5 minutes of ventilation with a normoxic gas mixture. Baseline pulmonary artery pressure change after exposure to each drug and hypoxic pressor response between a period 21% normoxic gas ventilation and that of 3% hypoxic gas ventilation were measured. RESULTS ATP and LTC4 + ATP increased baseline pulmonary artery pressures but LTC4 did not alter it. ATP did not affect hypoxic pressor response. Suramin, LY171883 and LTC4 + ATP inhibited the pressor response to hypoxia. LTC4 increased hypoxic pressor response. CONCLUSIONS In isolated rat lungs, HPV may be mediated by ATP and LTC4 appears more likely to be a modulator than a mediator of HPV.
Korean Journal of Anesthesiology | 2009
Ji Yoon Rho; Hwa Yong Shin; Hyun Chang Kim; Ji Won Lee; Seong Deok Kim
BACKGROUND Hypoxic pulmonary vasoconstriction (HPV) is unique to pulmonary circulation but the mechanism remains elusive. Red blood cells (RBCs) are known to augment HPV and to release more ATP as oxygen content falls. Leukotrienes constrict smooth muscle and could be important for the regulation of the pulmonary circulation. Hence we hypothesized that ATP and leukotrienes are mediators of HPV produced during acute alveolar hypoxia. METHODS In forty Sprague-Dawley rats, lungs were isolated and perfused. We administered ATP (10 micrometer) to the ATP group (n = 8), the ATP antagonist, suramin (100 micrometer) to the suramin group (n = 8), leukotriene C4 (LTC4, 5 microgram) to the LTC4 group (n = 8), the LTC4 antagonist, LY171883 (20 micrometer) to the LY171883 group (n = 8), and LTC4 (5 microgram) + ATP (10 micrometer) to the LTC4 + ATP group (n = 8) during normoxic ventilation. HPV responses were induced by three hypoxic challenges for 5 minutes separated by 5 minutes of ventilation with a normoxic gas mixture. Baseline pulmonary artery pressure change after exposure to each drug and hypoxic pressor response between a period 21% normoxic gas ventilation and that of 3% hypoxic gas ventilation were measured. RESULTS ATP and LTC4 + ATP increased baseline pulmonary artery pressures but LTC4 did not alter it. ATP did not affect hypoxic pressor response. Suramin, LY171883 and LTC4 + ATP inhibited the pressor response to hypoxia. LTC4 increased hypoxic pressor response. CONCLUSIONS In isolated rat lungs, HPV may be mediated by ATP and LTC4 appears more likely to be a modulator than a mediator of HPV.
Korean Journal of Anesthesiology | 2008
Yun Suk Choi; Yong Chul Kim; Sang-Hyun Park; Seung Yun Lee; Hwa Yong Shin; Ji yon Jo; Jung man Lee; Sang Chul Lee
The Korean Journal of Pain | 2007
Hwa Yong Shin; Yong Min Choi; Francis Sahngun Nahm; Seong Joo Park; Mi Suk Koo; Jeong Hun Suh; Sung Eun Sim; Ji Yon Jo; Sang Chul Lee; Yong Chul Kim
The Korean Journal of Pain | 2007
Jeong Hun Suh; Mi Suk Koo; Francis Sahngun Nahm; Hwa Yong Shin; Yong Min Choi; Ji Yon Jo; Sang Chul Lee; Yong Chul Kim
The Korean Journal of Pain | 2007
Yong Min Choi; Hwa Yong Shin; Kang Joon Lee; Mi Suk Koo; Francis Sahngun Nahm; Jeong Hun Suh; Ji Yon Jo; Yong Chul Kim; Sang Chul Lee
The Korean Journal of Pain | 2007
Ji Yon Jo; Jeong Hoon Suh; Hwa Yong Shin; Yong Min Choi; Moon Sun Bang; Sang Chul Lee; Yong Chul Kim
Korean Journal of Anesthesiology | 2006
Chul Joong Lee; Yong Chul Kim; Jae Hyuck Shin; Seung Yeon Yoo; Hwa Yong Shin; Yang Hyun Kim; Sun Sook Han; Ju Yeon Joh; Eun Hyeong Lee; Sang Chul Lee; Ji Hyun Park
Korean Journal of Anesthesiology | 2005
Ji Yoon Rho; Seong Deok Kim; Hwa Yong Shin
Archive | 2007
Yong Min Choi; Hwa Yong Shin; Kang Joon Lee; Mi Suk Koo; Francis Sahn; Jeong Hun Suh; Ji Yon Jo; Yong Chul Kim; Sang Chul Lee