Hye-Sun Park

Candidate genes of cerebral infarction and traditional classification in Koreans with cerebral infarction

Sasang constitutional medicine is a major branch of Korean traditional Oriental medicine. The differences of disease susceptibility to be shown in Sasang constitution may be due to genetic factors. Therefore, the authors examined relationship between candidate genes of cerebral infarction (CI) and Sasang constitution. The homozygous deletion allele of the angiotensin converting enzyme gene (ACE/DD), homozygous threonine allele of the angiotensinogen gene (AGN/TT), and the ϵ4 allele of the apolipoprotein E gene (ApoE/ϵ4) are reported to be associated with ischemic heart disease. CI is another atherosclerotic disease; and the effects of these polymorphisms on CI have been confusing. This study investigated whether ACE/DD, AGN/TT, and ApoE/ϵ4 genotypes are associated with CI and whether genetic risk is enhanced by Sasang constitutional classification. The authors ascertained these genotypes in patients with CI (N=211), diagnosed by brain computed tomography. Control subjects for the infarction group were randomly selected from 319 subjects matched for age, sex, and history of hypertension with patients. The ACE/DD genotype was not associated with CI. However, there was significant association between ApoE polymorphism and CI (χ2=15.089, p<.05). Furthermore, frequency of AGN/TT genotype was higher in the patients with CI than in the controls (χ2=20.072, p<.05). The frequency of T allele was 0.91 in patients and 0.82 in controls (χ2=17.237, p<.05). However, Sasang constitutional classification did not increase the relative risk for CI in the subjects with ApoE/ϵ4 or AGN/T allele. These results suggest that ApoE and AGN polymorphism predict CI, but Sasang constitutional classification does not enhance the risk for CI associated with ApoE/ϵ4 or AGN/TT in a Korean population.

Regulation of TH1/TH2 Cytokine Production by Chungsim-Yeunja-Tang in Patients with Cerebral Infarction

Chungsim-Yeunja-Tang is a prescription for the Taeumin cerebral infarction (CI) patients according to Sasang constitutional philosophy. Taeumin patients with CI were treated with CY-Tang during the acute stage. Clinical signs of CI disappeared markedly in about 2 weeks after oral administration of CY-Tang in all patients. The mean interleukin (IL)-2 plasma levels were slightly lower in the patients with CI than in the normal groups, whereas the mean TNF-α, IL-4, IL-6, and IgE levels were significantly higher in the patients with CI. There were no significant differences in interferon-γ (IFN-γ) levels between the groups. Serum IFN-γ and IL-2 levels derived from T helper (Th) 1 cells were significantly elevated in the patients with CI by CY-Tang administration. Significant reduced plasma levels of IL-4 and IL-6 derived from Th2 cells and IgE were observed in the patients treated with CY-Tang. Plasma levels of TNF-α derived from Th1 significantly increased in the patients treated with CY-Tang. During the period of CY-Tang administration, there were no other adverse effects. The data indicate that CY-Tang has a good CI treatment effect, and that its action may be due to the regulation of cytokine production.

Clinical Practice Guideline for Soyangin Disease of Sasang Constitutional Medicine: Chest-Heat congested (Hyunggyeok-yeol) Symptomatology

Abstract Clinical Practice Guideline for Soyangin Disease of Sasang Constitutional Medicine: Chest-Heat congested (Hyunggyeok-yeol) Symptomatology Hye-Sun Park * , Min-Woo Hwang, Eui-ju Lee * Dept. of Sasang Constitutional Medicine, College of Korean Medicine, Dongshin University, Jeollanam-do, KoreaDept. of Sasang Constitutional Medicine, College of Korean Medicine, Kyung Hee University, Seoul, KoreaObjectivesThis research was proposed to present Clinical Practice Guideline(CPG) for Soyangin Disease of Sasang ConstitutionalMedicine (SCM) ; Chest-Heat congested(Hyunggyeok-yeol) Symptomatology.Methods This CPG was developed by the national-wide experts committee consisting of SCM professors. First, collection and organization of literature related to SCM such as Donguisusebowon, Text book of SCM, Clinical Guidebook of SCM and Fundamental research to standardize diagnosis of Sasang Constitutional Medicine was performed.Secondly, journals related to clinical trial or Human complementary medicine of SCM were searched. Finally, 4 articles were selected and included in CPG for Chest-Heat congested(Hyunggyeok-yeol) Symptomatology of StomachHeat-based Interior Heat disease in Soyangin disease.Results & ConclusionsCPG of Chest-Heat congested(Hyunggyeok-yeol) symptomatology in Soyangin disease includes classification, definition and standard symptoms of each pattern. Chest-Heat congested(Hyunggyeok-yeol) symptomatology is classified into mild and moderate pattern by severity. Chest-Heat(Hyunggyeok-yeol) symptomatology Mild pattern is classified into Chest-Heat congested(Hyunggyeok-yeol) initial pattern and Chest-Heat congested(Hyunggyeok-yeol) advancedpattern. And Chest-Heat congested (Hyunggyeok-yeol) moderate pattern is classified into Clear Yang Failure of Stomach(Weguck-cheongyang Bulsagnseung) pattern (Upper wasting-thirst(Sangso) pattern), Clear Yang Failure of Large Intestine (Daejang-cheongyang Bulsangseung) pattern (Middle wasting-thirst (Jungso) pattern).Key Words: Sasang Constitutional Medicine(SCM), Clinical Practice Guideline, Soyangin, Hyunggyeok-yeol symptomatology.