Hyeong-Ho Jin

In vivo evaluation of porous hydroxyapatite/chitosan-alginate composite scaffolds for bone tissue engineering

Porous hydroxyapatite (HAp)/chitosan-alginate composite scaffolds were prepared through in situ co-precipitation and freeze-drying for bone tissue engineering. The composite scaffolds were highly porous and interconnected with a pore size of around 50-220 μm at low concentrations of HAp. As the HAp content increased, the porosity of the scaffolds decreased from 84.98 to 74.54%. An MTT assay indicates that the obtained scaffolds have no cytotoxic effects on MG-63 cells, and that they have good biocompatibility. An implantation experiment in mouse skulls revealed that the composite scaffold provides a strong positive effect on bone formation in vivo in mice. Furthermore, that HAp/chitosan-alginate composite scaffold has been shown to be more effective for new bone generation than chitosan-alginate scaffold.

Degradation Behavior of Hydroxyapatite with Different Crystallinity in Simulated Body Fluid Solution

Hydroxyapatite (HAp) powders with different crystallinities were synthesized at various calcination temperatures through the co-precipitation of and . The degradation behavior of these HAp powders with different crystallinities was assessed in a simulated body fluid solution (SBF) for 8 weeks. Below , the powders were nonstochiometric HAp, and the single HAp phase was successfully synthesized at . The degree of crystallinity of the HAp powders increased with an increasing calcination temperature and varied in a range from 39.6% to 92.5%. In the low crystallinity HAp powders, the Ca and P ion concentrations of the SBF solution increased with an increasing soaking time, which indicated that the low crystallinity HAp degraded in the SBF solution. The mass of the HAp powders linearly decreased with respect to the soaking time, and the mass loss was higher at lower crystallinities. The mass loss ranged from 0.8% to 13.2% after 8 weeks. The crystallinity of the HAp powders increased with an increasing soaking time up to 4 weeks and then decreased because of HAp degradation. The pH of the SBF solution did not change much throughout the course of these experiments. These results suggested that the crystallinity of HAp can be used to control the degradation.

마이크로파에 의해 합성된 β-TCP/PLGA 복합체의 의사체액에서의 분해 거동

【The biodegradable

Synthesis and bioactivity evaluation of metal ion-substitution biphasic calcium phosphate for bone defect reconstruction

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The Effect of MgO Content on the Preparation of Porous Hydroxyapaite Scaffolds by Polymer Sponge Method

-tricalcium phosphate (

In-situ formation of the hydroxyapatite/chitosan-alginate composite scaffolds

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In situ formation of biphasic calcium phosphates and their biological performance in vivo

-TCP)/poly(lactide-co-glycolide) (PLGA) composites were synthesized by in situ polymerization with microwave energy. The degradation behavior of

In situ synthesis of magnesium-substituted biphasic calcium phosphate and in vitro biodegradation

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Degradation behavior of poly(lactide-co-glycolide)/β-TCP composites prepared using microwave energy

-TCP/PLGA composite was investigated by soaking in simulated body fluid (SBF) for 4 weeks. The molecular weight of the

In situ synthesis of silicon-substituted biphasic calcium phosphate and their performance in vitro

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