Hyon-Yong Chong
Seoul National University
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Publication
Featured researches published by Hyon-Yong Chong.
Nature Biotechnology | 2005
Jeong-Sun Seo; Hyon-Yong Chong; Hyun Seok Park; Kyoung-Oh Yoon; Cholhee Jung; Jae Joon Kim; Jin Han Hong; Hyungtae Kim; Jeonghyun Kim; Joon-Il Kil; Cheol Ju Park; Hyun-Myung Oh; Jung-Soon Lee; Su-Jung Jin; Hye-Won Um; Hee-Jong Lee; Soo-Jin Oh; Jae Young Kim; Hyung Lyun Kang; Se Yong Lee; Kye Joon Lee; Hyen Sam Kang
We report the complete genome sequence of Zymomonas mobilis ZM4 (ATCC31821), an ethanologenic microorganism of interest for the production of fuel ethanol. The genome consists of 2,056,416 base pairs forming a circular chromosome with 1,998 open reading frames (ORFs) and three ribosomal RNA transcription units. The genome lacks recognizable genes for 6-phosphofructokinase, an essential enzyme in the Embden-Meyerhof-Parnas pathway, and for two enzymes in the tricarboxylic acid cycle, the 2-oxoglutarate dehydrogenase complex and malate dehydrogenase, so glucose can be metabolized only by the Entner-Doudoroff pathway. Whole genome microarrays were used for genomic comparisons with the Z. mobilis type strain ZM1 (ATCC10988) revealing that 54 ORFs predicted to encode for transport and secretory proteins, transcriptional regulators and oxidoreductase in the ZM4 strain were absent from ZM1. Most of these ORFs were also found to be actively transcribed in association with ethanol production by ZM4.
Nature Genetics | 2011
Young Seok Ju; Jong-Il Kim; Sheehyun Kim; Dongwan Hong; Hansoo Park; Jong Yeon Shin; Seungbok Lee; Won Chul Lee; Sujung Kim; Saet Byeol Yu; Sung Soo Park; Seung Hyun Seo; Ji Young Yun; Hyun Jin Kim; Dong Sung Lee; Maryam Yavartanoo; Hyunseok Peter Kang; Omer Gokcumen; Diddahally R. Govindaraju; Jung Hee Jung; Hyon-Yong Chong; Kap Seok Yang; Hyungtae Kim; Charles Lee; Jeong-Sun Seo
Massively parallel sequencing technologies have identified a broad spectrum of human genome diversity. Here we deep sequenced and correlated 18 genomes and 17 transcriptomes of unrelated Korean individuals. This has allowed us to construct a genome-wide map of common and rare variants and also identify variants formed during DNA-RNA transcription. We identified 9.56 million genomic variants, 23.2% of which appear to be previously unidentified. From transcriptome sequencing, we discovered 4,414 transcripts not previously annotated. Finally, we revealed 1,809 sites of transcriptional base modification, where the transcriptional landscape is different from the corresponding genomic sequences, and 580 sites of allele-specific expression. Our findings suggest that a considerable number of unexplored genomic variants still remain to be identified in the human genome, and that the integrated analysis of genome and transcriptome sequencing is powerful for understanding the diversity and functional aspects of human genomic variants.
Journal of Korean Medical Science | 2016
Wan Beom Park; Nak Jung Kwon; Pyoeng Gyun Choe; Su Jin Choi; Hong Sang Oh; Sang Min Lee; Hyon-Yong Chong; Jong-Il Kim; Kyoung-Ho Song; Ji Hwan Bang; Eu Suk Kim; Hong Bin Kim; Sang Won Park; Nam Joong Kim; Myoung Don Oh
During the 2015 outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) in Korea, 186 persons were infected, resulting in 38 fatalities. We isolated MERS-CoV from the oropharyngeal sample obtained from a patient of the outbreak. Cytopathic effects showing detachment and rounding of cells were observed in Vero cell cultures 3 days after inoculation of the sample. Spherical virus particles were observed by transmission electron microscopy. Full-length genome sequence of the virus isolate was obtained and phylogenetic analyses showed that it clustered with clade B of MERS-CoV.
Journal of Biotechnology | 2015
Sang Heum Shin; Hanseong Roh; Juhyeok Kim; Sukhyeong Cho; Youngsoon Um; Jinwon Lee; Yeon-Woo Ryu; Hyon-Yong Chong; Kap-Seok Yang
Here we report the full genome sequence of Klesiella oxytoca M1, isolated from Manripo area of South Korea. The strain K. oxytoca M1 is able to produce either 2,3-butanediol or acetoin selectively by controlling the pH and temperature.
Bioinformatics | 2012
Dongwan Hong; Arang Rhie; Sung-Soo Park; Jongkeun Lee; Young Seok Ju; Sujung Kim; Saet-Byeol Yu; Thomas Bleazard; Hyun Seok Park; Hwanseok Rhee; Hyon-Yong Chong; Kap-Seok Yang; Yeon-Su Lee; In-Hoo Kim; Jin Soo Lee; Jong-Il Kim; Jeong-Sun Seo
Archive | 2007
Jeong-Sun Seo; Hyon-Yong Chong; Jeonghyun Kim; Jae-Young Kim
Archive | 2011
Jae-Young Kim; Sang-Heum Shin; Hyon-Yong Chong; Kap-Seok Yang; Jeong-Sun Seo
Archive | 2011
Jae-Young Kim; Sang-Heum Shin; Hyon-Yong Chong; Kap-Seok Yang; Jeong-Sun Seo
Archive | 2011
Jae-Young Kim; 김재영; Sang-Heum Shin; 신상흠; Hyon-Yong Chong; 정현용; Kap-Seok Yang; 양갑석; Jeong-Sun Seo; 서정선
Archive | 2011
Jae-Young Kim; 김재영; Sang-Heum Shin; 신상흠; Hyon-Yong Chong; 정현용; Kap-Seok Yang; 양갑석; Jeong-Sun Seo; 서정선