Hyoung-Ryoul Kim

A novel function of haptoglobin : haptoglobin-haemoglobin complex induces apoptosis of hepatocarcinomatous Hep 3B cells

Haptoglobin-haemoglobin complex (Cx) showed a cytotoxic effect on the growth of Hep 3B (human hepatocellular carcinoma) cells, dose dependently. The antiproliferative effect of Cx on the multiplication of Hep 3B cells was augmented by the presence of prostaglandin (PG) D2. Antihuman Hb IgG abolished the effect of Cx, dose-dependently, which indicates that the antiproliferative effect of Cx really is exerted by Cx. Hep 3B cells treated with Cx showed the characteristic biochemical changes of apoptosis, such as DNA fragmentation which was blocked by pretreatment with cycloheximide, and the increase of transglutaminase expression. Thus, the antiproliferative effect of Cx against Hep 3B cells occurs via the typical apoptotic pathway.

Prevention of Work-Related Musculoskeletal Disorders

Editorial Work-related musculoskeletal disorders (WMSDs) constitute a major component of occupational diseases (ODs), accounting for approximately 38.1% of all ODs in Europe [1] and approximately 70% of all compensated ODs in Korea [2]. According to a recent European Union report, WMSDs tend to be underreported and are tending to increase among women, young, and migrant workers. The costs for upper extremity WMSDs alone rage from 0.5 to 3.8% of gross national product [3]. In the United States, costs for compensation, wage loss, and production loss range from 45–54 billion US dollors [4]. Research to prevent these highly costly WMSDs is being conducted in various fields including epidemiology, physiology, ergonomics, biomechanics, molegular biology, and genetics and to tackle such issues as return to work, rehabilitation, policy and compensation. One of the most important avenues of communication for these research efforts is the Intenational Conference on Prevention of Work-related Musculoskeletal Disorders (PREMUS). There are 35 active scientific committees in the International Commission on Occupational Health, and the Musculoskeletal Disorder Committee has held an international conference every 3 years under the name of PREMUS. The most recent PREMUS conference was held in Busan, Korea on July 7–11, 2013. It was the first time that PREMUS was organized outside of North America or Europe. Attending pariticipants were 290 scholars from 30 conutries all over the world, including 11 Asian countries. Among the many papers presented at the conference, 10 describing the spectrum of WMSDs research around world were chosen to public in AOEM. The study by Nur Azmar et al. shows the prevalence and psychosocial risk factors for WMSDs among Malaysian

Occupational Lung Cancer Surveillance in South Korea, 2006-2009

Objectives The lung cancer mortality in Korea has increased remarkably during the last 20 years, and has been the first leading cause of cancer-related deaths since 2000. The aim of the current study was to examine the time trends of occupational lung cancer and carcinogens exposure during the period 2006-2009 in South Korea, by assessing the proportion of occupational burden. Methods We defined occupational lung cancer for surveillance, and developed a reporting protocol and reporting website for the surveillance of occupational lung cancer. The study patients were chosen from 9 participating university hospitals in the following 7 areas: Seoul, Incheon, Wonju, Daejeon, Daegu, Busan, and Gwangju. Results The combined proportion of definite and probable occupational lung cancer among all lung cancers investigated in this study was 10.0%, 8.6%, 10.7%, and 15.8% in the years 2006 to 2009, respectively, with an average of 11.7% over the four-year study period. The main carcinogens were asbestos, crystalline silica, radon, polyaromatic hydrocarbons (PAHs), diesel exhaust particles, chromium, and nickel. Conclusion We estimated that about 11.7% of the incident lung cancer was preventable. This reveals the potential to considerably reduce lung cancer by intervention in occupational fields.