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Dive into the research topics where Hyuncheol Kim is active.

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Featured researches published by Hyuncheol Kim.


Annals of Biomedical Engineering | 2005

Study of Ocular Transport of Drugs Released from an Intravitreal Implant Using Magnetic Resonance Imaging

Hyuncheol Kim; Martin J. Lizak; Ginger Tansey; Karl G. Csaky; Michael R. Robinson; Peng Yuan; Nam Sun Wang; Robert J. Lutz

Ensuring optimum delivery of therapeutic agents in the eye requires detailed information about the transport mechanisms and elimination pathways available. This knowledge can guide the development of new drug delivery devices. In this study, we investigated the movement of a drug surrogate, Gd-DTPA (Magnevist®) released from a polymer-based implant in rabbit vitreous using T1-weighted magnetic resonance imaging (MRI). Intensity values in the MRI data were converted to concentration by comparison with calibration samples. Concentration profiles approaching pseudosteady state showed gradients from the implant toward the retinal surface, suggesting that diffusion was occurring into the retinal–choroidal–scleral (RCS) membrane. Gd-DTPA concentration varied from high values near the implant to lower values distal to the implant. Such regional concentration differences throughout the vitreous may have clinical significance when attempting to treat ubiquitous eye diseases using a single positional implant. We developed a finite element mathematical model of the rabbit eye and compared the MRI experimental concentration data with simulation concentration profiles. The model utilized a diffusion coefficient of Gd-DTPA in the vitreous of 2.8×10−6, cm2, s−1 and yielded a diffusion coefficient for Gd-DTPA through the simulated composite posterior membrane (representing the retina–choroid–sclera membrane) of 6.0×10−8, cm2, s−1. Since the model membrane was 0.03-cm thick, this resulted in an effective membrane permeability of 2.0×10−6, cm, s−1. Convective movement of Gd-DTPA was shown to have minimal effect on the concentration profiles since the Peclet number was 0.09 for this system.


Experimental Eye Research | 2006

A rabbit model for assessing the ocular barriers to the transscleral delivery of triamcinolone acetonide

Michael R. Robinson; Susan S. Lee; Hyuncheol Kim; Stephanie H. Kim; Robert J. Lutz; Craig J. Galbán; Peter M. Bungay; Peng Yuan; Nam Sun Wang; Jonghyeon Kim; Karl G. Csaky


Investigative Ophthalmology & Visual Science | 2006

A novel bioerodible deep scleral lamellar cyclosporine implant for uveitis

Brian C. Gilger; Jacklyn H. Salmon; David A. Wilkie; Lars P. J. Cruysberg; Jonghyeon Kim; Matthew J. Hayat; Hyuncheol Kim; Stephanie Kim; Peng Yuan; Susan S. Lee; Susan M. Harrington; Patrick R. Murray; Henry F. Edelhauser; Karl G. Csaky; Michael R. Robinson


Experimental Eye Research | 2006

The pharmacokinetics of rituximab following an intravitreal injection.

Hyuncheol Kim; Karl G. Csaky; Chi-Chao Chan; Peter M. Bungay; Robert J. Lutz; Robert L. Dedrick; Peng Yuan; Jay Rosenberg; Antonio J. Grillo-Lopez; Wyndham H. Wilson; Michael R. Robinson


Investigative Ophthalmology & Visual Science | 2005

Preclinical evaluation of a novel episcleral cyclosporine implant for ocular graft-versus-host disease

Hyuncheol Kim; Karl G. Csaky; Brian C. Gilger; James P. Dunn; Susan S. Lee; Marcus Tremblay; Francisco M. de Monasterio; Ginger Tansey; Peng Yuan; Peter M. Bungay; Robert J. Lutz; Michael R. Robinson


Investigative Ophthalmology & Visual Science | 2005

Transscleral-RPE Permeability of PEDF and Ovalbumin Proteins: Implications for Subconjunctival Protein Delivery

Robert N. Fariss; Maria M. Campos; W. Gerald Robison; Hyuncheol Kim; Robert J. Lutz; S. Patricia Becerra


Investigative Ophthalmology & Visual Science | 2007

A Pharmacokinetic and Safety Evaluation of an Episcleral Cyclosporine Implant for Potential Use in High-Risk Keratoplasty Rejection

Susan S. Lee; Hyuncheol Kim; Nam Sun Wang; Peter M. Bungay; Brian C. Gilger; Peng Yuan; Jonghyeon Kim; Karl G. Csaky; Michael R. Robinson


Investigative Ophthalmology & Visual Science | 2004

Preclinical Evaluation of a Triamcinolone Acetonide Preservative Free (TAC–PF) Formulation for Intravitreal Injection

Michael R. Robinson; Hyuncheol Kim; L. Gravlin; Ginger Tansey; G. Grimes; G. Potti; Peng Yuan; Karl G. Csaky


Investigative Ophthalmology & Visual Science | 2003

A Subconjunctival Implant for Delivery of Cytochalasin E in a Model of Choroidal Neovascularization: A Pilot Study

Hyuncheol Kim; Robert J. D'Amato; R.J. Lutz; Peng Yuan; Judit Baffi; J.D. Wolfe; G. Byrnes; Michael R. Robinson; Karl G. Csaky


Investigative Ophthalmology & Visual Science | 2005

The Pharmacokinetics of a Novel Episcleral Cyclosporine Implant for High–Risk Keratoplasties

Seakwoo Lee; Hyuncheol Kim; Nam Sun Wang; M. Tremblay; Peter M. Bungay; Robert J. Lutz; Peng Yuan; Karl G. Csaky; Michael R. Robinson

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Peng Yuan

National Institutes of Health

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Michael R. Robinson

National Institutes of Health

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Robert J. Lutz

National Institutes of Health

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Brian C. Gilger

North Carolina State University

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Susan S. Lee

National Institutes of Health

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Peter M. Bungay

National Institutes of Health

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