Hyung-Won Kang

Inhibitory action of water soluble fraction of Terminalia chebula on systemic and local anaphylaxis

We investigated the effects of the water soluble fraction of Terminalia chebula (Combretaceae) (WFTC) on systemic and local anaphylaxis. WFTC administered 1h before compound 48/80 injection inhibited compound 48/80-induced anaphylactic shock 100% with doses of 0.01-1.0 g/kg. When WFTC was administered 5 or 10 min after compound 48/80 injection, the mortality also decreased in a dose-dependent manner. Passive cutaneous anaphylaxis was inhibited by 63.5+/-7.8% by oral administration of WFTC (1.0 g/kg). When WFTC was pretreated at concentrations ranging from 0.005 to 1.0 g/kg, the serum histamine levels were reduced in a dose-dependent manner. WFTC (0.01-1.0 mg/ml) also significantly inhibited histamine release from rat peritoneal mast cells (RPMC) by compound 48/80. However, WFTC (1.0 mg/ml) had a significant increasing effect on anti-dinitrophenyl IgE-induced tumor necrosis factor-alpha production from RPMC. These results indicate that WFTC may possess a strong antianaphylactic action.

Acupuncture for Posttraumatic Stress Disorder: A Systematic Review of Randomized Controlled Trials and Prospective Clinical Trials

To evaluate the current evidence for effectiveness of acupuncture for posttraumatic stress disorder (PTSD) in the form of a systematic review, a systematic literature search was conducted in 23 electronic databases. Grey literature was also searched. The key search terms were “acupuncture” and “PTSD.” No language restrictions were imposed. We included all randomized or prospective clinical trials that evaluated acupuncture and its variants against a waitlist, sham acupuncture, conventional therapy control for PTSD, or without control. Four randomized controlled trials (RCTs) and 2 uncontrolled clinical trials (UCTs) out of 136 articles in total were systematically reviewed. One high-quality RCT reported that acupuncture was superior to waitlist control and therapeutic effects of acupuncture and cognitive-behavioral therapy (CBT) were similar based on the effect sizes. One RCT showed no statistical difference between acupuncture and selective serotonin reuptake inhibitors (SSRIs). One RCT reported a favorable effect of acupoint stimulation plus CBT against CBT alone. A meta-analysis of acupuncture plus moxibustion versus SSRI favored acupuncture plus moxibustion in three outcomes. This systematic review and meta-analysis suggest that the evidence of effectiveness of acupuncture for PTSD is encouraging but not cogent. Further qualified trials are needed to confirm whether acupuncture is effective for PTSD.

Oriental medicine Jangwonhwan reduces Aβ(1-42) level and β-amyloid deposition in the brain of Tg-APPswe/PS1dE9 mouse model of Alzheimer disease.

ETHNOPHARMACOLOGICAL RELEVANCE Jangwonhwan, a boiled extract of 12 medicinal plants/mushroom including Korean red ginseng (Panax ginseng C.A. Meyer), has been prescribed for patients with cognitive dysfunction and are believed to induce brain activity enhancement, provide light sedation, and facilitate sound sleep. AIM OF THE STUDY The present study was carried out to investigate whether Jangwonhwan has a beneficial effect on the brain of Alzheimer disease. MATERIALS AND METHODS The transgenic mice of Alzheimer disease, Tg-APPswe/PS1dE9, were fed a modified recipe of Jangwonhwan consisting of a boiled extract of 7 herbs/mushroom (called LMK02-Jangwonhwan) at 400mg/kg/day of dose for 3 months from 4.5 months of age. Immunohistological and ELISA analyses were used to assess the Abeta accumulation and plaque deposition in the brain. Other in vitro and in vivo works were performed to understand the underlying mechanism. RESULTS LMK02-Jangwonhwan notably reduced Abeta(1-42) and Abeta(1-40) levels, concomitantly with a reduction of plaque deposition, in the brain of Tg-APPswe/PS1dE9 mice. LMK02-Jangwonhwan partially suppressed oxidative stress accumulation, and prevented the down-regulation of phospho-CREB and calbindin typically seen in the hippocampus of AD-like brains. In vitro study with SH-SY5Y neuroblastoma cells showed that LMK02-Jangwonhwan inhibited oxidative stress and Abeta-induced neurotoxicity. CONCLUSION The present study suggests that LMK02-Jangwonhwan confers a therapeutic potential to ameliorate AD-like pathology in the brain of Tg-APPswe/PS1dE9 mice.

The Effects of Acupuncture Treatment on Hwa-byung patient's Insomnia: Patient-assessor blind, Randomized, Placebo-controlled Clinical trial

AbstractObjectives:The purpose of this research is to examine the effects of acupuncture treatment on Hwa-byung patients insomnia. Methods:The study was performed through a patient-assessor blind, rando mized, placebo-controlled trial in which the volunteers, data collectors and analysts were unaware of indivi duals who were receiving the treatment. A total of thirty-seven volunteers were divided into 2 groups. 18 subjects were placed into a trial group and 19 subjects into a control group by a randomization table. The trial group was t reated on bilateral Shigu, Ahnmyun, B62 (Shinmaek), and K6 (Chohae), while the control group was not gi ven any other treatment. The ISI(Insomnia Severity Scale) was measured as the 1st evaluative instrument, and then a comparative analysis was conducted by comparing the results with those measured by a Likert scale for major symptoms of Hwa-byung, PSQI, Hwa-byung scale, BDI, STAI, and STAXI. Results:In the ISI, PSQI, and the Likert scale regarding major symptoms of Hwa-byung, Hwa-byung scale, BDI, and STAI, more significant decreases were found in those concerning the trial group compared to those of the control group from a statistical perspective. However, in the STAXI, regardin g the trial group, there was no significant decrease compared to the control group. Conclusions:The results suggest that acupuncture treatment is effective in the treatment regarding Hwa-byung patients who suffer from insomnia. Keywords :Hwa-byung, insomnia, acupuncture treatment

Clinical Studies on HWANGRYUNHAEDOKTANG Herbal Acupuncture Therapy on Headache

Objective: There are many treatments for headache. We suggested the clinical effect and utilization of HWANGRYUNHAEDOKTANG herbal acupuncture on headache. Methods: 1. We injected distillation of HWANGRYUNHAEDOKTANG(2.0cc) on Both Pung-Ji(GB20) of patients. In 20 minutes later, We examined therapeutic value of headache. 2. We examined effects of HWANGRYUNHAEDOKTANG Herbal acupuncture by sex , age, area of headache, period of history, degree of headache. Results and Conclusions: 1. There was a significantly effect of HWANGRYUNHAEDOKTANG Herbal acupuncture on headache. 2. In therapeutic value, The effect of HWANGRYUNHAEDOKTANG Herbal acupuncture by each type is significant.

The Current State of Clinical Studies on Scalp Acupuncture - Treatment for Dementia-by Search for China Literature published from 2001 to 2011 in CAJ(China Academic Journals) -

Objectives : The purpose of this study was to obtain some knowledge concerning the scalp acupuncture treatment on patients with dementia for the future practice and research from clinical studies in China. Methods : The literatures were searched using the data base-China Academic Journals(CAJ) (2001-2011). Results : We found out 1 case study, and 17 randomized controlled trials(RCT) which met the inclusion criteria in most studies. There were 3 types of scalp acupuncture-applying method, cho-si scalp acupuncture(焦氏頭鍼法), combination of using ordinary acupoints(正經鍼) and extraordinary acupoints(經外寄穴), standard method of scalp acupuncture(標準頭鍼法). The often used acupoints are Yundongqu(運動區), Ganjuequ(感覺區), Yuntingqu(暈聽區), Zuyunganqu(足運感區), Sishencong (HN23), Baihui(GV20), Shenting(GV24), Fengchi(GB20), Dingnieqianxiexian(MS6), and Dingniehouxiexian(MS7). Conclusions : There were significant improvements on the scalp acupuncture-treated groups, compared to the control groups(western medication group or other acupuncture treatment group). Results of this study could be used for future studies concerning the scalp acupuncture for dementia.

A Study on the Reliability and Factor analysis of Pattern Identification for Tic Disorders in children

AbstractObjectives : We purposed to objectify the pattern diagnosis of Tic disorders through factor and reliability analysis regarding a pattern identification questionnaire concerning Tic disorders i n children. Methods : We chose and studied 144 children who were pattern-diagnosed ou t of 200 tic disordered children who visited H hospital in Seoul from January 2006 to April 2011.Results : 1. TTD (50%) was the most common type and the occurrence rate in male children was higher(4.76:1). Also, the rate of hospital visits was highest at the age 8(23.6%). 2. In results concering pattern diagnosis, Gan-poong-nae-dong w as most frequently diagnosed in 53 patients (36.8%), and Dam-hwa-yo-sin (42 patients), Gan-sin-um-her (30 p atients), and Bee-her-gan-wang (6 patients) .3. In an attempt to verify the reliability of the questionnaire, the coefficient regarding the whole questions (Cronbach α) came to 0.909. Moreover, the reliability coefficie nt foreach sub factor was 0.687 in Gan- poong-nae-dong, 0.817 in Dam-hwa-yo-sin, 0.851 in Bee-her-gan-w ang, and 0.726 in Gan-sin-um-her, respectively. Thus, their consistency was ensured.4. In exploratory factor analysis concerning the most common fi ve questions in the questionnaire, the questions of Dam-hwa-yo-sin and Gan-poong-nae-dong appeared to be part of di fferent factors. While, Gan-sin-um-her and Bee-her-gan-wang questions showed that they belong to the same factors.5. In factor analysis excluding both Gan-sin-um-her and Bee-her -gan-wang questions, both showed significant results; however, the one excluding Gan-sin-um-her showed improved resul ts.Conclusions : From the above results concerning the Pattern Identification Qu estionnaire for Tic Disordered children, three separated patterns of Bee-her-gan-wang, Dam-hwa-yo-sin, Gan-poo ng-nae-dong are thought to be available for clinical use. However, further validity studies are needed. Key Words : Tic disorders, Pattern Identification, Gan-poong-nae-dong

The Clinical Study of 3 menopausal disorder patients with Palpitation and Depression Treated by Yeongkyekamjo-tang

AbstractObjectives :The purpose of this study is to evaluate the effects of Yeongkyekamjo-tang on patients with menopausal disorder.Methods :We recruited 3 patients with menopausal disorder, who have been suffering from palpitation and depression. In addition, the patients had been administrated Yeongkyekamjo-tang. The patients of menopausal disorder had been estimated with Kuppermans index, Becks Depression Inventory, The Menopause Quiz of Argosy University, visual analogue scale and Heart rate variability. We measured the Kupp ermans index, Becks Depression Inventory and The Menopause Quiz of Argosy University for every seven days. T he heart rate variability was estimated twice, before and after the treatment.Results :After the treatments, symptoms of menopausal disorder were decreased.Conclusions :This study suggests that Yeongkyekamjo-tang is significantly effective on patients with menopausal disorder as well as palpitation and depression.Key Words:Yeongkyekamjo-tang, Menopausal disorder, Depression, Palpitation, Heart rate vari ability Received : May 27, 2012; Revised : June 3, 2012; Accepted : Jun e 6, 2012Correspondence : Yeoung-su Lyu, Wonkwang University Oriental Medicine Hospital 2-142-1, Dukjin-Dong Dukjin-Gu, Jeonju-Si Cheolabook-Do SOUTH KOREA 561-190Tel : 063-270-1021, Fax : 063-270-1594, E-mail : yslyu@wonkwa ng.ac.kr

A Study on Difference of Somatization Psychological Mechanism among Sasang Constitution(Four type constitution)

Objectives : The purpose of this study was to investigate the difference of somatization psychological mechanism among Sasang constitution. Methods : Subjects were seventy four students of Won-Kwang university responded the questionnaire. We evaulated the subjects using Minnesota Questionnaire for the Sasang Constitution Classification II(QSCC II), Multiphasic Personality Inventory-2(MMPI-2), 20-item Toronto Alexithymia Scale (TAS-20), Somato-Sensory Amplification Scale(SSAS), Symptom Interpretation Questionnaire(SIQ) and The Ways of Stress Coping Questionnaire(SCQ). Results : From the results of Clinical scale of MMPI-2, the scores of 2nd, 9th, 10th scales was significantly difference. In Lesser Yin group 10th score was the significantly highest of the others, 1st, 3rd, 6th, 7th, 8th score were the highest but not significant. and From the results of PSY-5 scale(The Personality Psychopathology Five scale) of MMPI-2, In Lesser Yin goup, INTR(Introversion/Low Positive Emotion) score was significantly highest, PSYC(psychoticism), NEGE (Negative Emotionality/Neuroticism) was higher than the others. In TAS-20K, SSAS, SIQ and SCQ Lesser Yin group was not significantly difference. but Lesser Yin group had the tendency of difficulty describing feelings and externally oriented thinking and higher score in physical and psychological interpretation. We observed generally lower levels of stress coping strategy scores than the others. Conclusions : These results showed that Lesser Yin group tend to somatization compared other constitution.

Evaluation on the Quality of Research Field with Traditional Herbal Prescriptions for Dementia Therapy

Objective : This study aimed to review the performance of traditional herbal prescriptions for treating dementia and present a strategy for research on dementia therapy utilizing herbal medicine. Methods : A definition was made to clarify the technology regarding the development of herbal prescriptions for treating dementia. The queries were compounded based on the initial keywords provided by experts in the field, then applied to the Web of Science database search engines from January 1986 to September 2011 to search related scientific articles. Before performing the analysis, papers were extracted from the initial search reviewed by experts and 80 articles were selected. Then, the selected papers were analyzed in terms of publish year, country, and type of herbal prescriptions. Furthermore, the research performance evaluation for treating dementia by herbal prescriptions was also created in terms of country and organization based on forward citation analysis. In addition to, for the evaluation regarding research quality, we classified and reviewed papers into two types: clinical studies and experimental studies. Results : According to the quantitative information analysis of 80 articles, the number of papers has increased by 21.9% per the yearly mean from 1995, and Japan had the largest portion within this research field. There were 34 kinds of traditional herbal prescriptions, among them Ukgansan had the highest number of studies followed by Jodeungsan, Dangkisoosan and so on. In addition, quality index as calculated by cites per paper is higher than average in Switzerland, Turkey and Japan. In the view of the evaluation on quality there were 12 clinical studies, 8 RCT reported that herbal prescriptions had efficacy at cognition, behavioral & psychological symptoms (BPSD) and activity of daily life (ADL) in various type of dementia. In experimental studies most of the studies were performed using animal models. The studies using Ukgansan were aimed at improving BPSD. The papers studied with Jodeungsan and Dangkisoosan targeted vascular dementia. Conclusions : In this study, research to develop traditional herbal prescriptions for treating dementia has the potential to improve symptoms since herbal medicines work as both multi-function and multi-target in dementia with multiple pathological or neurotoxic pathways. Therefore, the results of the research should be used in order to establish strategies to develop technology for treating dementia with traditional herbal prescriptions in the future.