HyunWook Park

Motion estimation using low-band-shift method for wavelet-based moving-picture coding

The discrete wavelet transform (DWT) has several advantages of multiresolution analysis and subband decomposition, which has been successfully used in image processing. However, the shift-variant property is intrinsic due to the decimation process of the wavelet transform, and it makes the wavelet-domain motion estimation and compensation inefficient. To overcome the shift-variant property, a low-band-shift method is proposed and a motion estimation and compensation method in the wavelet-domain is presented. The proposed method has a superior performance to the conventional motion estimation methods in terms of the mean absolute difference (MAD) as well as the subjective quality. The proposed method can be a model method for the motion estimation in wavelet-domain just like the full-search block matching in the spatial domain.

Blocking effect reduction of JPEG images by signal adaptive filtering

A postprocessing algorithm is proposed to reduce the blocking artifacts of Joint Photographic Experts Group (JPEG) decompressed images. The reconstructed images from JPEG compression produce noticeable image degradation near the block boundaries, in particular for highly compressed images, because each block is transformed and quantized independently. The blocking effects are classified into three types of noises in this paper: grid noise, staircase noise, and corner outlier. The proposed postprocessing algorithm, which consists of three stages, reduces these blocking artifacts efficiently. A comparison study between the proposed algorithm and other postprocessing algorithms is made by computer simulation with several JPEG images.

Biomimetic approach to cardiac tissue engineering

Here, we review an approach to tissue engineering of functional myocardium that is biomimetic in nature, as it involves the use of culture systems designed to recapitulate some aspects of the actual in vivo environment. To mimic the capillary network, subpopulations of neonatal rat heart cells were cultured on a highly porous elastomer scaffold with a parallel array of channels perfused with culture medium. To mimic oxygen supply by haemoglobin, the culture medium was supplemented with a perfluorocarbon (PFC) emulsion. Constructs cultivated in the presence of PFC contained higher amounts of DNA and cardiac markers and had significantly better contractile properties than control constructs cultured without PFC. To induce synchronous contractions of cultured constructs, electrical signals mimicking those in native heart were applied. Over only 8 days of cultivation, electrical stimulation induced cell alignment and coupling, markedly increased the amplitude of synchronous construct contractions and resulted in a remarkable level of ultrastructural organization. The biomimetic approach is discussed in the overall context of cardiac tissue engineering, and the possibility to engineer functional human cardiac grafts based on human stem cells.

Bioinspired Synthesis and Characterization of Gadolinium-Labeled Magnetite Nanoparticles for Dual Contrast T1- and T2-Weighted Magnetic Resonance Imaging

Gadolinium-labeled magnetite nanoparticles (GMNPs) were synthesized via a bioinspired manner to use as dual contrast agents for T1- and T2-weighted magnetic resonance imaging. A mussel-derived adhesive moiety, 3,4-dihydroxy-l-phenylalanine (DOPA), was utilized as a robust anchor to form a mixed layer of poly(ethylene glycol) (PEG) chains and dopamine molecules on the surface of iron oxide nanoparticles. Gadolinium ions were subsequently complexed at the distal end of the dopamine molecules that were prefunctionalized with a chelating ligand for gadolinium. The resultant GMNPs exhibited high dispersion stability in aqueous solution. Crystal structure and superparamagnetic properties of magnetite nanocrystals were also maintained after the complexation of gadolinium. The potential of GMNPs as dual contrast agents for T1 and T2-weighted magnetic resonance imaging was demonstrated by conducting in vitro and in vivo imaging and relaxivity measurements.

L/M-fold image resizing in block-DCT domain using symmetric convolution

Image resizing is to change an image size by upsampling or downsampling of a digital image. Most still images and video frames on digital media are given in a compressed domain. Image resizing of a compressed image can be performed in the spatial domain via decompression and recompression. In general, resizing of a compressed image in a compressed domain is much faster than that in the spatial domain. We propose a novel approach to resize images with L/M resizing ratio in the discrete cosine transform (DCT) domain, which exploits the multiplication-convolution property of DCT (multiplication in the spatial domain corresponds to symmetric convolution in the DCT domain). When an image is given in terms of its 8 x 8 block-DCT coefficients, its resized image is also obtained in 8 x 8 block-DCT coefficients. The proposed approach is computationally fast and produces visually fine images with high PSNR.

Loop filtering and post-filtering for low-bit-rates moving picture coding

Abstract When an image is highly compressed by using the current coding standards, the decompressed image has noticeable image degradations such as blocking artifacts near the block boundaries, corner outliers at cross points of blocks and ringing noise near image edges. These image degradations are caused by quantization process of the 8×8 DCT coefficients. In order to restore the decompressed image, a loop-filtering algorithm and a post-filtering algorithm have been developed. The developed methods perform an adaptive filtering on the decompressed image according to blocking and ringing flags that are defined to reduce computation complexity. Performances of both algorithms are compared with respect to the image quality and the computation complexity. The comparison results show that the post-filtering is slightly better than or similar to the loop filtering with respect to peak signal-to-noise ratio (PSNR), whereas the subjective image qualities of both methods are quite similar. However, the computation complexity of the loop filtering is much less than that of the post-filtering.

In Vivo Visualization of White Matter Fiber Tracts of Preterm- and Term-Infant Brains With Diffusion Tensor Magnetic Resonance Imaging

Objective:The goal of this study was to test the feasibility of visualizing a 3-dimensional structure of cerebral white matter fiber tracts in preterm infants, postconceptional age (PCA) 28 weeks to term, by using volumetric diffusion tensor magnetic resonance imaging (DTI) data. Materials and Method:We combined tractography algorithms and visualization methods, currently available for adult DTI data, to trace the pixelated principal direction of a diffusion tensor originating from regions-of-interest with high fractional anisotropy. Consequently, white matter fiber bundles from the genu and the splenium of corpus callosum, the corticospinal tracts, the inferior fronto-occipital fasciculi, and optic radiations were visualized. Results:Our results suggest that major white matter tracts of preterm infant brains, with PCAs ranging from 28 weeks to term (40 weeks old), can be successfully visualized despite the small brain volume and low anisotropy. Conclusion:The feasibility of fiber tractography in preterm neonates with DTI may add a new dimension in detection and characterization of white matter injuries of preterm infants.

Facile synthetic route for surface-functionalized magnetic nanoparticles: cell labeling and magnetic resonance imaging studies.

Currently available methods to stably disperse iron oxide nanoparticles (IONPs) in aqueous solution need to be improved due to potential aggregation, reduction of superparamagnetism, and the use of toxic reagents. Herein, we present a facile strategy for aqueous transfer and dispersion of organic-synthesized IONPs using only polyethylene glycol (PEG), a biocompatible polymer. A library of PEG derivatives was screened, and it was determined that amine-functionalized six-armed PEG, 6(PEG-NH(2)), was the most effective dispersion agent. The 6(PEG-NH(2))-modified IONPs (IONP-6PEG) were stable after extensive washing, exhibited high superparamagnetism, and could be used as a platform material for secondary surface functionalization with bioactive polymers. IONP-6PEG biofunctionalized with hyaluronic acid (IONP-6PEG-HA) was shown to specifically label mesenchymal stem cells and demonstrate MR contrast potential with high r(2) relaxivity (442.7 s(-1)mM(-1)) compared to the commercially available Feridex (182.1 s(-1)mM(-1)).

A prototype MR insertable brain PET using tileable GAPD arrays

The aim of this study is to develop a MR compatible PET that is insertable to MRI and allows simultaneous PET and MR imaging of human brain. The brain PET having 72 detector modules arranged in a ring of 330 mm diameter was constructed and mounted in a 3-T MRI. Each PET module composed of 4 × 4 matrix of 3 mm × 3 mm × 20 mm LYSO crystals coupled to a tileable 4 × 4 array Geiger-mode avalanche photodiode (GAPD) and designed to locate between RF and gradient coils. GAPD output charge signals were transferred to preamplifiers using flat cable of 3 m long, and then sent to position decoder circuit (PDC) identifying digital address and generating an analog pulse of the one interacted channel from preamplifier signals. The PDC outputs were fed into FPGA-embedded DAQ boards. The analog signal was digitized, and arrival time and energy of the signal were calculated and stored. LYSO and GAPD were located inside MR bore and all electronics including preamplifiers were positioned outside MR bore to minimize signal interference between PET and MR. Simultaneous PET/MR images of a hot-rod and Hoffman brain phantom were acquired in a 3-T MRI using the MR compatible PET system. The rods down to a diameter of 3.5 mm were resolved in the hot-rod PET image. Activity distribution patterns between white and gray matter in Hoffman brain phantom were well imaged. No degradation of image quality of the hot-rod and Hoffman brain phantoms on the simultaneously acquired MR images obtained with standard sequences was observed. These results demonstrate that simultaneous acquisition of PET and MR images is feasible using the MR insertable PET developed in this study.

Neural correlates of eye blinking; improved by simultaneous fMRI and EOG measurement

Neural correlates of eye blink in healthy human subjects can be investigated using functional magnetic resonance imaging. However, the focus of most previous studies has been on intentional eye blinking. The goal of the present study was to examine the neural correlates of spontaneous eye blinking with the help of EOG measurements during data acquisition of fMRI. After the removal of the pulse artifact in the EOG signal, EOG waveform clearly indicates eye blinking, which was equivalent to those measured outside of the MRI scanner. On the basis of this detection, each blinking event can be used as a temporal cue for the event-related fMRI. In a comparison, we also investigated the neural correlates of blink inhibition. Based on the brain activation pattern, the activation of the bilateral parahippocampal, the visual cortex was commonly observed for both conditions. The additional activation of the precentral gyrus, corresponding to blink inhibition, and the right medial frontal gyrus, corresponding to spontaneous blinking were observed. Based on these results, we conclude that the medial frontal gyrus is responsible for spontaneous eye blinking, whereas precentral activation appears to be related to blink inhibition.