I. Charles

Synthesis of aminoglycoside-DNA conjugates.

Development of aminoglycoside-nucleic acid conjugates is presented. Synthesis of a DNA dimer covalently linked to kanamycin and neomycin isothiocyanates has been carried out. The development of such conjugates will help couple the sequence specificity of nucleic acids to the electrostatic/shape complementarity of aminoglycoside antibiotics in binding nucleic acid targets.

Pyrene–neomycin conjugate: dual recognition of a DNA triple helix

We report the synthesis of pyrene-neomycin conjugate and its ability to stabilize DNA/RNA triple helices.

Synthesis of Neomycin‐DNA/Peptide Nucleic Acid Conjugates

Syntheses of neomycin conjugates of DNA and peptide nucleic acid (PNA) is reported. The DNA and PNA conjugates were prepared by coupling neomycin isothiocyanate with the amino group of DNA/PNA in order to form a thiourea linkage. The use of neomycin isothiocyanate as an electrophilic reagent for a general route to aminoglycoside‐coupled nucleic acid biopolymers is described.