I. H. Leach

Two cases of delayed granulomatous reactions to the cosmetic filler Dermalive®, a hyaluronic acid and acrylic hydrogel

1 Frieling U, Bonsmann G, Schwarz T et al. Treatment of severe lichen planus with mycophenolate mofetil. J Am Acad Dermatol 2003; 49:1063–6. 2 Eisman S, Orteu CH. Recalcitrant erosive flexural lichen planus: successful treatment with a combination of thalidomide and 0Æ1% tacrolimus ointment. Clin Exp Dermatol 2004; 29:268–70. 3 Erdem MT, Gulec AI, Kiziltunc A et al. Increased serum levels of tumor necrosis factor alpha in lichen planus. Dermatology 2003; 207:367–70. 4 Simon M Jr, Gruschwitz MS. In situ expression and serum levels of tumour necrosis factor alpha receptors in patients with lichen planus. Acta Derm Venereol (Stockh) 1997; 77:191–3. 5 Eisen D. The clinical features, malignant potential, and systemic associations of oral lichen planus: a study of 723 patients. J Am Acad Dermatol 2002; 46:207–14. 6 Lear JT, English JS. Erosive and generalized lichen planus responsive to azathioprine. Clin Exp Dermatol 1996; 21:56–7. 7 Kopp H, Reymann FE. Lichen planus treated with Grenz rays; preliminary report. Acta Derm Venereol (Stockh) 1956; 36:477–81. 8 Cribier B, Frances C, Chosidow O. Treatment of lichen planus. An evidence-based medicine analysis of efficacy. Arch Dermatol 1998; 134:1521–30.

Usefulness of the QuantiFERON test in the confirmation of latent tuberculosis in association with erythema induratum.

with B-cell malignancies. Br J Dermatol 2006; 155:379–86. 6 Hallermann C, Kjell MK, Tiemann M et al. High frequency of primary cutaneous lymphomas associated with lymphoproliferative disorders of different lineage. Ann Hematol 2007; 86:509–15. 7 van den Berg A, Maggio E, Rust R et al. Clonal relation in a case of CLL, ALCL, and Hodgkin’s composite lymphoma. Blood 2002; 100:1425–9. 8 Assaf C, Hummel M, Dippel E et al. Common clonal T-cell origin in a patient with T-prolymphocytic leukaemia and associated cutaneous T-cell lymphomas. Br J Haematol 2003; 120:488–91. 9 Kang SK, Chang SE, Choi JH et al. Coexistence of CD30-positive anaplastic large cell lymphoma and mycosis fungoides. Clin Exp Dermatol 2002; 27:212–15. 10 Lee MW, Chi DH, Choi JH et al. A case of mycosis fungoides after CD30 positive anaplastic large cell lymphoma. J Dermatol 2000; 27:458–61.

Two squamous cell carcinomas arising in a linear epidermal naevus in a 28-year-old female

The development of a squamous cell carcinoma (SCC) in a linear epidermal naevus is a rare event previously reported in long‐standing and often extensive lesions of middle‐aged to elderly patients. To the best of our knowledge, this case appears to be only the second report of an SCC arising in a linear epidermal naevus in a young patient and the first report of two SCCs developing in a small epidermal naevus, over a short time, in a young patient with no other risk factors.

Chilblain-like Leukemia Cutis

Abstract:  We present a 6‐year‐old girl with an 8‐month history of fluctuating chilblain‐like lesions on the toes. A full blood count showed slight thrombocytopenia and monocytosis. A skin biopsy specimen showed a dense perivascular and superficial dermal cellular infiltrate which was CD3−, CD43+, and lysosyme + on immunocytochemistry, suggesting a monocytic origin. Juvenile myelomonocytic leukemia was diagnosed after a bone marrow biopsy and spontaneous marrow colony growth in culture.

Systemic mastocytosis with diffuse cutaneous involvement and haematological disease presenting in utero treated unsuccessfully with vincristine

Mastocytosis is a disorder characterised by abnormal mast cell proliferation. The diverse spectrum of clinical presentations is dependent on the tissues and organs involved. We report a rare case of aggressive systemic mastocytosis presenting in utero with diffuse cutaneous involvement, and haematological abnormalities. There is little published evidence to guide treatment.

Dermatitis artefacta in a 12-year-old girl mimicking cutaneous T-cell lymphoma.

Abstract:  Dermatitis artefacta or factitious disease may be unrecognized in children. We present a 12‐year‐old girl who had an unusual facial lesion on the chin, which was self‐inflicted but histologically mimicked cutaneous T‐cell lymphoma. Our report emphasizes both the potential diagnostic pitfalls and the importance of clinicopathologic correlation.

Johnson square procedure for lentigo maligna and lentigo maligna melanoma.

Lentigo maligna (LM) and lentigo maligna melanoma (LMM) can be difficult to manage surgically. Predetermined margins can be inadequate because of subclinical spread, or can affect function when margins are adjacent to the eye or mouth.

A novel case of follicular mucinosis after autologous stem-cell transplantation for multiple myeloma.

Follicular mucinosis is a rare inflammatory disorder of unknown aetiology, characterized by mucin deposition in hair follicles and sebaceous glands. FM can occur as a benign idiopathic primary disorder or secondary to malignant lymphoproliferative processes, most notably mycosis fungoides. We report a novel case of FM developing after autologous stem‐cell transplantation for multiple myeloma, a correlation not previously reported in the literature.

A painful blue nodule on the leg.

A 43-year-old Asian woman presented with a 10-year history of a slowly enlarging lesion on the lower leg that she attributed to local trauma. The lesion was tender, especially at night. There was no other significant medical history. Clinical examination revealed a solitary, bluish nodular lesion measuring 23 · 16 · 2 mm on the left shin with a paler white area in the centre (Fig. 1). The lesion was mobile and felt firm with a suggestion of a deep dermal or subcutaneous component.