I. Loyber

Effects of handling normal and bulbectomized rats at adrenal and plasma corticosterone levels

Normal and bulbectomized adult rats, male and female, handled daily for 4 weeks, show plasma and adrenal corticosterone values significantly lower than the non-handled ones.

Insulin Sensitivity and Glucose Tolerance in Rats Without Olfactory Bulbs

Blood sugar and hepatic glycogen were analyzed and glucose and insulin-tolerance tests were performed in male and female rats, 15 and 30 days after resection of the olfactory bulbs. No change was obse

Plasma Corticosterone in Adult and Immature Rats without Olfactory Bulbs

Plasma corticosterone levels and the weight of adrenal glands were studied in rats deprived of olfactory bulbs. The bulbectomy was performed in two groups: (A) adult rats; and (B) 30-day-old immature rats. It was found that plasma corticosterone decreased significantly in adult rats, 30 and 45 days after bulbectomy: from 29.6 ± 1.77 to 22.2 ± 1.12 µg/100 ml (p µg/100 ml in those bulbectomized (p

Removal of Olfactory Bulbs in Rats of Different Ages: Repercussion on Some Metabolic Constants

The object of this investigation is to study effects of bulbectomy on female rats operated on at 15 and 30 days of age (prepubescent), 50 days (pubescent) and 120 days (adult), with respect to various parameters: these comprise corporal weight, liver weight, blood sugar, liver glycogen, glucose tolerance test and serum free fatty acid. Results were as follows. Body weight: in all groups this was significantly less than in controls except for rats operated on at adult age. Liver weight: (% of body weight) decreases in all groups, but significantly only in animals operated on when 15 days old. Blood sugar: significantly lessened in rats operated on when 30 and 120 days old. Liver glycogen: lessens in rats operated on at 30 and 120 days of age, but significantly only in the former. Glucose tolerance test: the coefficient k is found to increase in rats operated on at 15, 30 and 120 days of age; there is a significant increase in the first two groups. Serum free fatty acids: no marked alterations in any of the groups.

Changes in serum proteins due to lesion or resection of the olfactory bulbs of the rat

La sección y extirpación bilateral de los bulbos olfactorios, en ratas de ambos sexos, producen disminución de las proteínas séricas totales, albumina y globulinasα yΒ, sin modificaciones de la globulinaγ. Esa disminución se hace significativa 21 días después de las operaciones.

Effects on serum proteins of stimulation of olfactory bulbs in spinal rats

Abstract It has been shown in previous studies that resection or electrochemical stimulation of the olfactory bulbs modifies serum proteins in the rat, and that these changes are effected through the adrenal glands. In this study two routes are put forward through which the influence of the bulbs on serum proteins would be exerted: one joining the olfactory bulbs with the adrenal glands, passing through the hypothalamo and the hypophysis, which would act to change ACTH secretion; the other would be a nervous pathway, joining the olfactory bulbs with the adrenal medulla, passing through the spinal cord. To study the first way, bulbs were stimulated in a group of subjects to which dexamethasone was administered, and to study the second way the bulbs were stimulated in a group of subjects with sectioned spinal cord. It was observed that dexamethasone impeded the increase of albumin and alpha globulin that was seen on stimulating the bulbs in uninjected control subjects. The sectioning of the spinal cord only impeded an albumin increase on stimulating the bulbs. In subjects with spinal cord transection, the administration of corticosterone increased alpha globulin, and the administration of adrenalin did not produce an increase in either of the two fractions, but the simultaneous administration of both hormones increased both fractions. These results appear to confirm the existence of both pathways that would join the olfactory bulbs with the adrenal glands functionally.

The effects of stimulation of the olfactory bulbs on the serum proteins of the rat.

La estimulación electroquímica bilateral de bulbos olfatorios con corriente directa de 1 mA durante 10 segundos en ratas, produce aumento de concentration de proteinas séricas totales, albúmina y globulina α.

Exteroceptive olfactory stimuli: Their influence on plasma corticosterone in rats

Abstract The present study was carried out with a view to ascertaining the importance of exteroceptive olfactory stimuli during the decrease of plasma corticosterone produced in bulbectomized rats. For this purpose, normal rats, with sectioned olfactory nerves and extirpated olfactory bulbs were used; the plasma corticosterone levels in bulbectomized rats were significantly lower than in the other 2 groups under study. On the other hand, in rats with sectioned olfactory nerves, there were no significant changes of corticosterone when compared with normal animals. These results would indicate that the decrease of plasma corticosterone in bulbectomized rats might be due to a disruption in the nonolfactory function of olfactory bulbs.

Circulating Thyroxine Levels in Institutionalized Children

The circulating levels of total thyroxine (T4) and normalized thyroxine (T4N) were studied in 41 institutionalized children (IC) and in 22 control children (CC), from two to six years old. No difference were observed in the values of T4 between the two groups but in IC, T4N levels are inferior to those in CC. The periods children have been confined, their chronological age and their age at the time of admittance greatly influence these results. The differences between IC and CC become important in the IC groups with less than 6 months of confinement and with more than 24 months, in the groups of 4-year-old children and in the ones admitted before 1 year of age or after 4 years of age. In all parameters studied, the differences with CC in girls are more significant than in boys.