I. O. Olanrewaju

Functionalized Benzimidazole Scaffolds: Privileged Heterocycle for Drug Design in Therapeutic Medicine

Benzimidazole derivatives are crucial structural scaffolds found in diverse libraries of biologically active compounds which are therapeutically useful agents in drug discovery and medicinal research. They are structural isosteres of naturally occurring nucleotides, which allows them to interact with the biopolymers of living systems. Hence, there is a need to couple the latest information with the earlier documentations to understand the current status of the benzimidazole nucleus in medicinal chemistry research. This present work unveils the benzimidazole core as a multifunctional nucleus that serves as a resourceful tool of information for synthetic modifications of old existing candidates in order to tackle drug resistance bottlenecks in therapeutic medicine. This manuscript deals with the recent advances in the synthesis of benzimidazole derivatives, the widespread biological activities as well as pharmacokinetic reports. These present them as a toolbox for fighting infectious diseases and also make them excellent candidates for future drug design.

Corrosion Inhibitive Effect of 2-(1-(2-Oxo-2H-Chromen-3-Yl) Ethylidene) Hydrazine Carboxamide on Zinc-Aluminum Alloy in 1.8M Hydrochloric Acid

Introduction: Ethiopian communities highly depend on local plants to safe and sound their survival and health. Local trees are subjugated and used intensively for medicinal uses. Objective: The aim of the present study was too carried out phytochemical analysis of organic extract of Hagenia abyssinica and to find out antihelmentic property of Hagenia abyssinica. Methods: Hagenia abyssinica female flower extracts was used for plant component analysis and for determination of antihelmentic activity. Earth worm (Pheretima posthuma) strains were used for experimental purpose. Disc diffusion method was used to assess the antibacterial effect of the extracts on micro-organisms. Results: The phytochemical screening indicated the presence of flavonoids, tannins, steroid, alkaloid, saponins in all extracts. Antibacterial and antihelmentic activity of Ethanolic, Methanolic, Hexane and Petroleum Ether extract of Hagenia abyssinica female flowers was highly active against Adult earthworm (Pheritima posthuma) and active against Staphyloccoccus aureus and showed less activity against Salmonella typhi. Conclusion: The present study finally demonstrates that Hagenia abyssinica is a good source of various phytochemical such as Saponins, Phlobathanins, Flavonoids, Anthraquinones, Phenols, Terpenoids, Alkaloids, Steroids, Glycosides, Tannins. The antibacterial activity Hagenia abyssinica was clearly shown by the present study against bacteria. All these preliminary reports affirm an in depth analysis of the usefulness of Hagenia abyssinica as miracle drug against various ailments.