I. Sh. Salikhov

SYNTHESIS OF SOME POLYCYCLIC NONCONDENSED PYRIMIDINE STRUCTURES

Methods for the synthesis of compounds containing two or more pyrimidine rings linked through aliphatic chains with different numbers of carbon atoms are described.

Reaction of the sodium salts of some hydroxypyrimidines with. cap alpha. ,omega-dihaloalkanes. Communication 4. Synthesis of N-(omega-Haloalkyl)uracils

ConclusionsA method has been developed for the preparation of 1,3-bis(ω-haloalkyl)uracils with methylene chains of different lengths in the ω-haloalkyl radicals in the N1 and N3 positions of the pyrimidine ring.

Alkylation of oxypurines by α,ω-dihaloalkanes 1. Reaction of xanthine sodium salts and some N-methyl derivatives with α,ω-dihaloalkanes

A method was developed for obtaining previously unknown 1,3,7-tris(ω-haloalkyl)-, 1,7-bis(ω-chloroalkyl)-3-methyl-, and 1,3-bis(ω-chloropentyl)-7-methylxanthines.

Reaction of Na salts of hydroxypyrimidines with α,ω-dihaloalkanes. 3. reaction of Na salts of certain aminohydroxypyrimidines and 5,5-diethylbarbituric acid with α,ω-dihaloalkanes

Conclusions1.The reaction of Na salts of certain aminohydroxypyrimidines with α,ω-dihaloalkanes has been studied. A one-stage method of preparation of 4-(ω-haloalkyloxy)aminopyrimidines has been developed.2.The sodium salt of 5,5-diethylbarbituric acid reacts with α,ω-dihaloalkanes to form N-(ω-haloalkyl); and l,3-bis(ω-haloalkyl)-5,5-diethylbarbituric acids.

Reaction of Na salts of some hydroxypyrimidines with α, ω-dibromoalkanes

Conclusions1.The reaction of the Na salts of hydroxypyrimidines withα,ω-dibromoalkanes gives, besides N-(ω-bromoalkyl)dihydrooxopyrimidines, also the intermolecular transalkylation products.2.The structures of the products obtained by reacting equimolar amounts of the Na salt of 6-methyluracil andα,ω-dibromoalkanes, with a variable number of methylene groups between the bromine atoms, were established and the reasons for the predominant formation of oligomeric products in the given reactions were discussed.

Reaction of the sodium salts of several hydroxypyrimidines withα,ω-dihaloalkanes

A simple one-step method for the synthesis of 1,3-bis(ω-haloalkyl)uracils by reacting the Na salts of uracil and its derivatives with α,ω-dihaloalkanes has been developed.