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Ian Churcher

Merck & Co.

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Publication

Featured researches published by Ian Churcher.

Bioorganic & Medicinal Chemistry Letters | 2003

A new series of potent benzodiazepine γ-secretase inhibitors

Ian Churcher; Kate Ashton; John W. Butcher; Earl E. Clarke; Timothy Harrison; Huw D. Lewis; Andrew Pate Owens; Martin Richard Teall; Susie Williams; Jonathan D.J. Wrigley

Abstract A new series of benzodiazepine-containing γ-secretase inhibitors with potential use in the treatment of Alzheimers disease is disclosed. Structure–activity relationships of the pendant hydrocinnamate side-chain which led to the preparation of highly potent inhibitors are described.

Bioorganic & Medicinal Chemistry Letters | 2006

4-Substituted cyclohexyl sulfones as potent, orally active γ-secretase inhibitors

Ian Churcher; Dirk Beher; Jonathan D. Best; José L. Castro; Earl E. Clarke; Amy Gentry; Timothy Harrison; Laure Hitzel; Euan Kay; Sonia Kerrad; Huw D. Lewis; Pablo Morentin-Gutierrez; Russell J. Mortishire-Smith; Paul Joseph Oakley; Michael Reilly; Duncan E. Shaw; Mark S. Shearman; Martin Richard Teall; Susie Williams; Jonathan D.J. Wrigley

Archive | 2001

Sulphones which modulate the action of gamma-secretase

Jose Luis Castro Pineiro; Ian Churcher; Kevin Dinnell; Timothy Harrison; Sonia Kerrad; Alan Nadin; Paul Joseph Oakley; Andrew Pate Owens; Duncan Edward Shaw; Martin Richard Teall; Susannah William; Brian John Williams

Archive | 2001

BENZODIAZEPINE DERIVATIVES AS INHIBITORS OF GAMMA SECRETASE

Ian Churcher; Alan Nadin; Andrew Pate Owens

Archive | 2004

1-alkyl-3-thio-substituted indole-2-alkynoic acids useful for the treatment for alzheimer's disease and related conditions

Dirk Beher; Michela Bettati; Ian Churcher; Benito Munzo; Petpiboon Prasit; Abdul Quddus; Nicholas Stock; Jonathan D.J. Wrigley

Archive | 2005

Arylacetic Acids and Related Compounds for Treatment of Alzheimer's Disease

Peter Blurton; Frank Burkamp; Ian Churcher; Timothy Harrison; Joseph George Neduvelil

Archive | 2004

Treatment for alzheimer s disease and related conditions

Dirk Beher; Michela Bettati; Graham David Checksfield; Ian Churcher; Victoria Alexandra Doughty; Paul Joseph Oakley; Abdul Quddus; Martin Richard Teall; Jonathan D.J. Wrigley

Archive | 2007

Treatment of Alzheimer's Disease and Related Conditions

Ian Churcher; Peter Hunt; Matthew G. Stanton

Archive | 2005

(4, 5, 6, 7-TETRAHYDRO-1-H-INDOL-7-YL) ACETIC ACID DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE

Michela Bettati; Ian Churcher; Victoria Alexandra Doughty; Timothy Harrison; Emmanuela Nizi; Adam Smith

Archive | 2007

Indazole Derivatives for Treatment of Alzheimer's Disease

Ian Churcher; Hedaythul I. Choudhury; Peter Hunt; Richard Alexander Jelley; Alan John Nadin; Carmel B. Nanthakumar; Peter B. Simpson; Neil Wilkie

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Timothy Harrison

Merck

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Jonathan D.J. Wrigley

Merck

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Martin Richard Teall

Merck

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Michela Bettati

Merck

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Peter Hunt

Merck

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Abdul Quddus

Merck

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Dirk Beher

Merck

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Huw D. Lewis

Merck

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Paul Joseph Oakley

Merck

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Andrew Pate Owens

Merck

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