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Ian G. Wright

Eli Lilly and Company

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Tetrahedron Letters | 1991

Enantioselective acylation of a beta-lactam intermediate in the synthesis of loracarbef using penicillin G amidase

Milton J. Zmijewski; Barbara Shreve Briggs; Allen R. Thompson; Ian G. Wright

Penicillin G amidase from E. coli has been shown to selectively acylate, in an efficient manner, the (2R,3S) isomer of a cis, racemic azetidinone intermediate used in a synthesis of loracarbef, a carbacephalosporin antibiotic. The acylation occurs using methyl phenylacetate (MPA) and using methyl phenoxyacetate (MPOA) as the acylating agents. The enzyme displays similar enantioselectivity with MPOA or MPA.

Journal of Organic Chemistry | 1998

An Enantioselective Synthesis of Cis Perhydroisoquinoline LY235959

Marvin M. Hansen; Carl Franklin Indianapolis Bertsch; Allen R. Harkness; Bret E. Huff; Darrell R. Hutchison; Vien V. Khau; Michael E. LeTourneau; Michael John Martinelli; Jerry W. Misner; Barry C. Peterson; John A. Rieck; Kevin A. Sullivan; Ian G. Wright

Archive | 1979

Process and intermediates for preparing cephalosporin antibiotics

Ian G. Wright

Archive | 1968

REDUCTION OF DELTA**3-CEPHALOSPORIN SULFOXIDES

Robin D. G. Cooper; Earle Marvin Van Heyningen; G. V. Kaiser; Charles F. Murphy; J. Alan Webber; Ian G. Wright

Archive | 1990

Method of resolving cis 3-amino-4-[2-(2-furyl)eth-1-yl]-1-methoxycarbonylmethyl-azetidin-2-one

Ian G. Wright

Archive | 1977

4-Desacetoxy-4-oxovinblastine

Ian G. Wright; Norbert Neuss

Archive | 1990

Method of resolving cis 3-amino-4-[2-(2-furyl)eth-1-yl]-1-methoxycarbonylmethyl-azetidin-2-one using (-)-DAG

John Allan Rieck; Ian G. Wright

Archive | 1976

7-Carboxy or 2,2,2-trichloroethoxy carbonyl- cephalosporins

Wayne A. Spitzer; Ian G. Wright

Archive | 1973

PROCESS FOR ACETYLATION

Douglas O. Spry; Ian G. Wright

Archive | 1991

Method of resolving cis 3-amino-4-[2-(2-furyl)eth-1-yl]-1-methoxycarbonylmethyl-aze idin-2-one

John A. Rieck; Ian G. Wright

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G. V. Kaiser

Eli Lilly and Company

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Norbert Neuss

Eli Lilly and Company

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Charles F. Murphy

Eli Lilly and Company

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Earle Marvin Van Heyningen

Eli Lilly and Company

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Gerald Lee Thompson

Eli Lilly and Company

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John A. Rieck

Miami University

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Robin D. G. Cooper

Eli Lilly and Company

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Allen R. Harkness

Eli Lilly and Company

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Allen R. Thompson

Eli Lilly and Company

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Barbara Shreve Briggs

Eli Lilly and Company

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