Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Ian N. Stanton is active.

Publication


Featured researches published by Ian N. Stanton.


Journal of the American Chemical Society | 2012

Effect of solvent polarity and electrophilicity on quantum yields and solvatochromic shifts of single-walled carbon nanotube photoluminescence.

Brian A. Larsen; Pravas Deria; Josh M. Holt; Ian N. Stanton; Michael J. Heben; Michael J. Therien; Jeffrey L. Blackburn

In this work, we investigate the impact of the solvation environment on single-walled carbon nanotube (SWCNT) photoluminescence quantum yield and optical transition energies (E(ii)) using a highly charged aryleneethynylene polymer. This novel surfactant produces dispersions in a variety of polar solvents having a wide range of dielectric constants (methanol, dimethyl sulfoxide, aqueous dimethylformamide, and deuterium oxide). Because a common surfactant can be used while maintaining a constant SWCNT-surfactant morphology, we are able to straightforwardly evaluate the impact of the solvation environment upon SWCNT optical properties. We find that (i) the SWCNT quantum yield is strongly dependent on both the polarity and electrophilicity of the solvent and (ii) solvatochromic shifts correlate with the extent of SWCNT solvation. These findings provide a deeper understanding of the environmental dependence of SWCNT excitonic properties and underscore that the solvent provides a tool with which to modulate SWCNT electronic and optical properties.


Nanoscale | 2014

Europium- and lithium-doped yttrium oxide nanocrystals that provide a linear emissive response with X-ray radiation exposure

Ian N. Stanton; Matthew D. Belley; Giao Nguyen; A Rodrigues; Yifan Li; David G. Kirsch; Terry T. Yoshizumi; Michael J. Therien

Eu- and Li-doped yttrium oxide nanocrystals [Y2-xO3; Eux, Liy], in which Eu and Li dopant ion concentrations were systematically varied, were developed and characterized (TEM, XRD, Raman spectroscopic, UV-excited lifetime, and ICP-AES data) in order to define the most emissive compositions under specific X-ray excitation conditions. These optimized [Y2-xO3; Eux, Liy] compositions display scintillation responses that: (i) correlate linearly with incident radiation exposure at X-ray energies spanning from 40-220 kVp, and (ii) manifest no evidence of scintillation intensity saturation at the highest evaluated radiation exposures [up to 4 Roentgen per second]. For the most emissive nanoscale scintillator composition, [Y1.9O3; Eu0.1, Li0.16], excitation energies of 40, 120, and 220 kVp were chosen to probe the dependence of the integrated emission intensity upon X-ray exposure-rate in energy regimes having different mass-attenuation coefficients and where either the photoelectric or the Compton effect governs the scintillation mechanism. These experiments demonstrate for the first time for that for comparable radiation exposures, when the scintillation mechanism is governed by the photoelectric effect and a comparably larger mass-attenuation coefficient (120 kVp excitation), greater integrated emission intensities are recorded relative to excitation energies where the Compton effect regulates scintillation (220 kVp) in nanoscale [Y2-xO3; Eux] crystals. Nanoscale [Y1.9O3; Eu0.1, Li0.16] (70 ± 20 nm) was further exploited as a detector material in a prototype fiber-optic radiation sensor. The scintillation intensity from the [Y1.9O3; Eu0.1, Li0.16]-modified, 400 μm sized optical fiber tip, recorded using a CCD-photodetector and integrated over the 605-617 nm wavelength domain, was correlated with radiation exposure using a Precision XRAD 225Cx small-animal image guided radiation therapy (IGRT) system. For both 80 and 225 kVp energies, this radiotransparent device recorded scintillation intensities that tracked linearly with total radiation exposure, highlighting its capability to provide alternately accurate dosimetry measurements for both diagnostic imaging (80 kVp) and radiation therapy treatment (225 kVp).


Medical Physics | 2015

Fiber-optic detector for real time dosimetry of a micro-planar x-ray beam.

Matthew D. Belley; Ian N. Stanton; M Hadsell; R Ger; Brian W. Langloss; Jianping Lu; Otto Zhou; S Chang; Michael J. Therien; Terry T. Yoshizumi

PURPOSE Here, the authors describe a dosimetry measurement technique for microbeam radiation therapy using a nanoparticle-terminated fiber-optic dosimeter (nano-FOD). METHODS The nano-FOD was placed in the center of a 2 cm diameter mouse phantom to measure the deep tissue dose and lateral beam profile of a planar x-ray microbeam. RESULTS The continuous dose rate at the x-ray microbeam peak measured with the nano-FOD was 1.91 ± 0.06 cGy s(-1), a value 2.7% higher than that determined via radiochromic film measurements (1.86 ± 0.15 cGy s(-1)). The nano-FOD-determined lateral beam full-width half max value of 420 μm exceeded that measured using radiochromic film (320 μm). Due to the 8° angle of the collimated microbeam and resulting volumetric effects within the scintillator, the profile measurements reported here are estimated to achieve a resolution of ∼0.1 mm; however, for a beam angle of 0°, the theoretical resolution would approach the thickness of the scintillator (∼0.01 mm). CONCLUSIONS This work provides proof-of-concept data and demonstrates that the novel nano-FOD device can be used to perform real-time dosimetry in microbeam radiation therapy to measure the continuous dose rate at the x-ray microbeam peak as well as the lateral beam shape.


Journal of Materials Chemistry C | 2015

Electronic and optical properties of Er-doped Y2O2S phosphors

M. Pokhrel; G. A. Kumar; C.-G. Ma; M. G. Brik; Brian W. Langloss; Ian N. Stanton; Michael J. Therien; Dhiraj K. Sardar; Yuanbing Mao

In this paper, we report a detailed computational and experimental investigation of the structural, electronic and dynamic properties of undoped and Er3+-doped Y2O2S phosphors by using computational crystal field (CF) calculations and electronic density of states by density functional theory (DFT), combined with optical measurements including excitation spectra, emission spectra from X-ray, ultraviolet and near infrared (NIR) excitations, and quantum yield determination under ultraviolet and NIR excitations. Emission decays and quantum yields of the visible and NIR bands were measured for different Er3+ doping concentrations in the Er3+-doped Y2O2S phosphors. Results show that green (550 nm) and red (667 nm) emission intensity and the respective ratio of these emission intensities depend on both the excitation wavelength and the Er3+ doping concentration. Although the total emission efficiency does not appreciably depend on the excitation wavelength, the excitation wavelength that provided the highest efficiency was found to be 250 nm in these Er3+-doped Y2O2S phosphors with both 1% and 10% Er doping concentrations.


Proceedings of SPIE | 2012

Investigations on x-ray luminescence CT for small animal imaging

Cristian T. Badea; Ian N. Stanton; Samuel M. Johnston; G. A. Johnson; Michael J. Therien

X-ray Luminescence CT (XLCT) is a hybrid imaging modality combining x-ray and optical imaging in which x-ray luminescent nanophosphors (NPs) are used as emissive imaging probes. NPs are easily excited using common CT energy x-ray beams, and the NP luminescence is efficiently collected using sensitive light-based detection systems. XLCT can be recognized as a close analog to fluorescence diffuse optical tomography (FDOT). However, XLCT has remarkable advantages over FDOT due to the substantial excitation penetration depths provided by x-rays relative to laser light sources, long-term photo-stability of NPs, and the ability to tune NP emission within the NIR spectral window. Since XCLT uses an x-ray pencil beam excitation, the emitted light can be measured and back-projected along the x-ray path during reconstruction, where the size of the x-ray pencil beam determines the resolution for XLCT. In addition, no background signal competes with NP luminescence (i.e., no auto fluorescence) in XLCT. Currently, no small animal XLCT system has been proposed or tested. This paper investigates an XLCT system built and integrated with a dual source micro-CT system. A novel sampling paradigms that results in more efficient scanning is proposed and tested via simulations. Our preliminary experimental results in phantoms indicate that a basic CT-like reconstruction is able to recover a map of the NP locations and differences in NP concentrations. With the proposed dual source system and faster scanning approaches, XLCT has the potential to revolutionize molecular imaging in preclinical studies.


Medical Physics | 2014

WE-F-16A-04: Micro-Irradiator Treatment Verification with High-Resolution 3D-Printed Rodent-Morphic Dosimeters

S Bache; Matthew D. Belley; R Benning; Ian N. Stanton; Michael J. Therien; Terry T. Yoshizumi; J Adamovics; M Oldham

PURPOSE Pre-clinical micro-radiation therapy studies often utilize very small beams (∼0.5-5mm), and require accurate dose delivery in order to effectively investigate treatment efficacy. Here we present a novel high-resolution absolute 3D dosimetry procedure, capable of ∼100-micron isotopic dosimetry in anatomically accurate rodent-morphic phantoms METHODS: Anatomically accurate rat-shaped 3D dosimeters were made using 3D printing techniques from outer body contours and spinal contours outlined on CT. The dosimeters were made from a radiochromic plastic material PRESAGE, and incorporated high-Z PRESASGE inserts mimicking the spine. A simulated 180-degree spinal arc treatment was delivered through a 2 step process: (i) cone-beam-CT image-guided positioning was performed to precisely position the rat-dosimeter for treatment on the XRad225 small animal irradiator, then (ii) treatment was delivered with a simulated spine-treatment with a 180-degree arc with 20mm x 10mm cone at 225 kVp. Dose distribution was determined from the optical density change using a high-resolution in-house optical-CT system. Absolute dosimetry was enabled through calibration against a novel nano-particle scintillation detector positioned in a channel in the center of the distribution. RESULTS Sufficient contrast between regular PRESAGE (tissue equivalent) and high-Z PRESAGE (spinal insert) was observed to enable highly accurate image-guided alignment and targeting. The PRESAGE was found to have linear optical density (OD) change sensitivity with respect to dose (R2 = 0.9993). Absolute dose for 360-second irradiation at isocenter was found to be 9.21Gy when measured with OD change, and 9.4Gy with nano-particle detector- an agreement within 2%. The 3D dose distribution was measured at 500-micron resolution CONCLUSION: This work demonstrates for the first time, the feasibility of accurate absolute 3D dose measurement in anatomically accurate rat phantoms containing variable density PRESAGE material (tissue equivalent and bone equivalent). This method enables precise treatment verification of micro-radiation therapies, and enhances the robustness of tumor radio-response studies. This work was supported by NIH R01CA100835.


Brachytherapy | 2018

Real-time dose-rate monitoring with gynecologic brachytherapy: Results of an initial clinical trial

Matthew D. Belley; Oana Craciunescu; Zheng Chang; Brian W. Langloss; Ian N. Stanton; Terry T. Yoshizumi; Michael J. Therien; Junzo Chino

PURPOSE A nanoscintillator-based fiber-optic dosimeter (nanoFOD) was developed to measure real-time dose rate during high-dose-rate (HDR) brachytherapy. A trial was designed to prospectively test clinical feasibility in gynecologic implants. METHODS AND MATERIALS A clinical trial enrolled women undergoing vaginal cylinder HDR brachytherapy. The nanoFOD was fixed to the cylinder alongside two thermoluminescent dosimeters (TLDs). Treatment was delivered and real-time dose rates captured by the nanoFOD. The nanoFOD and TLD positions were identified in CT images and used to extract the treatment planning system (TPS) calculated dose. The nanoFOD and TLD cumulative doses were compared with the TPS. RESULTS Nine women were enrolled for 30 fractions, and real-time data were available in 27 treatments. The median ratio of nanoFOD/TPS dose was 1.00 (IQR 0.94-1.02), with a TLD/TPS ratio of 1.01 (IQR 0.98-1.04). Of the nanoFOD dose measurements, 63% were within 5% of the TPS, 26% between 5 and 10% of the TPS, and the remaining 11% between 10 and 20% of the TPS dose. Of the TLD measurements, 70% were within 5% of the TPS, 22% between 5 and 10% of the TPS, and 7% between 10 and 20% of the TPS dose. CONCLUSIONS Real-time dose-rate measurements during HDR brachytherapy were feasible using the nanoFOD and cumulative dose per fraction showed reasonable agreement to TLD and TPS doses. Additional studies to determine dose thresholds that would yield a low false alarm rate and ongoing device development efforts to improve localization of the scintillator in CT images are needed before this detector should be used to inform clinical decisions.


Medical Physics | 2015

WE-AB-BRB-12: Nanoscintillator Fiber-Optic Detector System for Microbeam Radiation Therapy Dosimetry

J Rivera; J Dooley; Matthew D. Belley; Ian N. Stanton; Brian W. Langloss; Michael J. Therien; Terry T. Yoshizumi; S Chang

Purpose: Microbeam Radiation Therapy (MRT) is an experimental radiation therapy that has demonstrated a higher therapeutic ratio than conventional radiation therapy in animal studies. There are several roadblocks in translating the promising treatment technology to clinical application, one of which is the lack of a real-time, high-resolution dosimeter. Current clinical radiation detectors have poor spatial resolution and, as such, are unsuitable for measuring microbeams with submillimeter-scale widths. Although GafChromic film has high spatial resolution, it lacks the real-time dosimetry capability necessary for MRT preclinical research and potential clinical use. In this work we have demonstrated the feasibility of using a nanoscintillator fiber-optic detector (nanoFOD) system for real-time MRT dosimetry. Methods: A microplanar beam array is generated using a x-ray research irradiator and a custom-made, microbeam-forming collimator. The newest generation nanoFOD has an effective size of 70 µm in the measurement direction and was calibrated against a kV ion chamber (RadCal Accu-Pro) in open field geometry. We have written a computer script that performs automatic data collection with immediate background subtraction. A computer-controlled detector positioning stage is used to precisely measure the microbeam peak dose and beam profile by translating the stage during data collection. We test the new generation nanoFOD system, with increased active scintillation volume, against the previous generation system. Both raw and processed data are time-stamped and recorded to enable future post-processing. Results: The real-time microbeam dosimetry system worked as expected. The new generation dosimeter has approximately double the active volume compared to the previous generation resulting in over 900% increase in signal. The active volume of the dosimeter still provided the spatial resolution that meets the Nyquist criterion for our microbeam widths. Conclusion: We have demonstrated that real-time dosimetry of MRT microbeams is feasible using a nanoscintillator fiber-optic detector with integrated positioning system.


Medical Physics | 2013

SU‐E‐T‐106: Validation of a Nanoparticle Terminated Fiber Optic Dosimeter On 6 MV LINAC for Photon and Electron Beams in a Solid Water Phantom

Matthew D. Belley; Ian N. Stanton; S Chang; Michael J. Therien; Terry T. Yoshizumi

PURPOSE Patient safety and dose-monitoring during routine radiotherapy treatments is of paramount importance to modern and future medical procedures and subsequent care. Currently, there are few, if any, options for real time in-vivo dosimetry, necessitating the need for a point dosimeter that is cost-effective, responds in real time, and exhibits minimal aging. The primary goal was to determine if a novel, nanoscintillator based fiber optic dosimeter, with dimensions less than a millimeter thick and several meters long, would respond linearly with increasing dose on a 6MV Photon and 6MeV Electron beam. METHODS A Siemens Primus LINAC was used with a solid water phantom, 10×10cm field size, 100cm SSD, 0 degree gantry angle, and 300MU/min dose rate. The sensor was placed at a depth of 1.5cm in the phantom (d_max). For the 6MV photon beam, cumulative doses of 1, 5, 10, and 15Gy to water were delivered. For the 6MeV electron beam, cumulative doses of 1, 5, and 10Gy to water were delivered. To form the sensor, YEuO nanoparticle powder was pressed into a bulk material and fixed to the end of a 600 micron optical fiber. This fiber connected to a Thor Labs PM100USB power meter and photodiode which measured light output in real time. RESULTS The linearity of the nanoscintillator based fiber optic dosimeter for 6MV photons and 6MV electrons had R-squared values of 0.99997 for both, with slopes of 5.707e-10 Joules/Gy and 1.468e-10 Joules/Gy respectively. CONCLUSION The nanoscintillator based fiber optic dosimeter response was linear with respect to increasing dose, indicating that with calibration, this detector could be used for real time in-vivo dosimetry for both electron and photon radiation therapy. The scintillation output was roughly 4 times greater for photons compared to electrons. No aging effects were observed for a cumulative dose of 150Gy to water.


Archive | 2010

Non-invasive energy upconversion methods and systems for in-situ photobiomodulation

Tuan Vo-Dinh; Jonathan P. Scaffidi; Venkata Gopal Reddy Chada; Benoit Lauly; Yan Zhang; Molly K. Gregas; Ian N. Stanton; Joshua T. Stecher; Michael J. Therien; Frederic A. Bourke; Harold Walder; Zak Fathi; Jennifer Ayres; Zhenyuan Zhang; Joseph H. Simmons; Stephen J. Norton

Collaboration


Dive into the Ian N. Stanton's collaboration.

Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Researchain Logo
Decentralizing Knowledge