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Clinica Chimica Acta | 1978

Angiotensin I-converting enzyme in human urine

Tatsuo Kokubu; Ichijiro Kato; Kazutaka Nishimura; Kunio Hiwada; Einosuke Ueda

It was demonstrated that angiotensin I-converting enzyme was excreted in human urine. The mean activity of the enzyme in normal urine was found to be 0.38 +/- 0.04 (S.E.M.) units/day (n = 18) and the enzymic activity correlated well with the concentration of the excreted sodium (r = 0.76, p less than 0.005). Urinary angiotensin I-converting enzyme was partially purified. Three different molecular weights of enzyme (greater than 400 000, 290 000 and 140 000) were demonstrated by Sephadex G-200 gel filtration. The enzymic properties of these three enzymes were identical with those of angiotensin I-converting enzyme from human lung with regard to inhibitory effects (bradykinin potentiator c and Arg-Pro-Pro), Cl- dependency, pH optimum and KM value.


Japanese Journal of Medicine | 1989

A Case of Isolated Thyrotropin Deficiency with Cushing's Syndrome

Yuji Hara; Michihito Sekiya; Makoto Suzuki; Kunio Hiwada; Ichijiro Kato; Tatsuo Kokubu


The Japanese journal of thoracic diseases | 1978

[Intracellular distribution of angiotensin I-converting enzyme in sarcoid lymph nodes (author's transl)].

Einosuke Ueda; Kazutaka Nishimura; Ichijiro Kato; Yuji Hayashi; Tatsuo Kokubu; Teruo Tachibana


The Japanese journal of thoracic diseases | 1979

[Angiotensin I-converting enzyme activity in serum and in the lung of rabbits with experimental pneumonitis (author's transl)].

Einosuke Ueda; Tadafumi Joh; Kazutaka Nishimura; Ichijiro Kato; Takaaki Ochi; Yuji Hayashi; Hitoshi Kukita; Tadao Kawabe; Tatsuro Kokubu


Japanese Circulation Journal-english Edition | 1980

THE ROLE OF RENIN-ANGIOTENSIN SYSTEM IN ONE KIDNEY-ONE CLIP AND TWO KIDNEY-ONE CLIP HYPERTENSIVE RATS IN CHRONIC PHASE: EFFECTS OF CAPTOPRIL : Hypertension : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY

Haruhisa Hashimoto; Eiki Murakami; Ichijiro Kato; Taiji Takada; Kunio Hiwada; Tatsuo Kokubu


Japanese Circulation Journal-english Edition | 1979

Response of urinary noradrenaline excretion to reserpine administration in normal and hypertensive subjects.

Einosuke Ueda; Yuji Hayashi; Tadao Kawabe; Ichijiro Kato; Noriko Yoshida; Tatsuo Kokubu


臨床化学シンポジウム | 1978

A-11. ヒト肺アンヂオテンシンI変換酵素の化学的性質と血圧調節

Kazutaka Nishimura; Tatsuo Kokubu; Noriko Yoshida; Ichijiro Kato


The Japanese journal of thoracic diseases | 1978

[Serum angiotensin I-converting enzyme activity in various pulmonary diseases (author's transl)].

Tatsuro Kokubu; Einosuke Ueda; Kazutaka Nishimura; Ichijiro Kato; Tadao Kawabe; Yukio Nagasaka; Fumihiko Kitatani; Kunihiko Yokoyama; Hiroshi Akutsu; Yoshizumi Sera; Teruo Tachibana


The Japanese journal of thoracic diseases | 1978

[Existence and properties of angiotensin I-converting enzyme in sarcoid lymph nodes (author's transl)].

Einosuke Ueda; Kazutaka Nishimura; Ichijiro Kato; Yuji Hayashi; Tatsuo Kokubu; Teruo Tachibana


Japanese Circulation Journal-english Edition | 1978

-275-HUMAN LUNG ANGIOTENSIN I-CONVERTING ENZYME AND THE EFFECT OF INHIBITORS : Renin,Angiotensin : PROCEEDINGS OF THE 42nd ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY

Ichijiro Kato; Kazutaka Nishimura; Kunio Hiwada; Einosuke Ueda; Tatsuo Kokubu

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