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Annals of the New York Academy of Sciences | 1970

SPECIFIC INHIBITOR FOR RNA REPLICASE

Ichiro Haruna; Itaru Watanabe; Yujiro Yamada; Kozo Nagaoka

It was thought that multiplication of phage RNA i s independent of the nucleic acid synthesis of the host cell. If this is the case , there may be an inhibitor for phage RNA multiplication which does not interf e re with the host nucleic acid synthesis. The isolation in 1965 of the RNA replicase in bacteriophage Q P by I. Haruna and S. Spiegelmanl permit us to tes t the validity of this hypothesis by enzymatic methods. That is, a specific inhibitor for RNA replicase may be found which will protect the host cell f rom RNA phage infection without any ser ious damage. plant virus containing RNA. case.


Bulletin of the Chemical Society of Japan | 1956

Hydrazinolysis of Peptides and Proteins. II. Fundamental Studies on the Determination of the Carboxyl-ends of Proteins

Shiro Akabori; Ko Ohno; Tokuji Ikenaka; Yoshimi Okada; Hidesaburo Hanafusa; Ichiro Haruna; Akira Tsugita; Kin-Ichi Sugae; Taijiro Matsushima


Virology | 1969

Comparison of coat proteins from three groups of RNA phages

Tohru Nishihara; Ichiro Haruna; Itaru Watanabe; Yuzo Nozu; Yoshimi Okada


Proceedings of the Japan Academy | 1968

Specific Inhibition of RNA Replicase by Certain Chemical Compounds

Itaru Watanabe; Ichiro Haruna; Yujiro Yamada; Kozo Nagaoka; Shigeo Seki


Journal of Biochemistry | 1981

In Vitro Replication of Bacteriophage GA RNA--Subunit Structure and Catalytic Properties of GA Replicase

Tetsuro Yonesaki; Ichiro Haruna


Journal of Biochemistry | 1978

Identification of host-derived subunits of phage SP RNA-dependent RNA polymerase (SP replicase).

Hiroshi Mori; Yasuo Fukami; Ichiro Haruna


Proceedings of the Japan Academy | 1970

Isolation of an RNA-dependent RNA Polymerase from Friend Murine Leukemia Cells

Ichiro Haruna; Tsuneya Ohno; Itaru Watanabe; Yoji Ikawa


Proceedings of the Japan Academy | 1969

Specific Inhibition of Qβ-Replicase Activity by Tobacco Mosaic Virus Ribonucleic Acid

Yoshimi Okada; Takeshi Ohno; Ichiro Haruna


Nature | 1972

Change in the Template Specificity of RNA Phage SP-Replicase by the E. coli Cell Component

Tohru Nlshihara; Ichiro Haruna; Nobuhisa Yamaguchi; Itaru Watanabe


Japanese Journal of Microbiology | 1973

Specific inhibition of Qbeta-replicase by fragmented Qbeta-ribonucleic acid.

Kuniko Yamane; Ichiro Haruna; Itaru Watanabe

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