Ichiro Kirikae

Combined surgery, radiotherapy, and regional chemotherapy in carcinoma of the paranasal sinuses.

Since 1964, we have been using the simultaneous combined therapy of surgery, radiotherapy, and regional chemotherapy in treating malignant tumors of the paranasal sinuses. Total number of cases treated was 68. In 57 cases of carcinomas 38 showed disappearance of tumor by this therapy and among these, 22 required no further treatment. In 19 cases of still existing tumor at the end of the therapy, partial resection of the maxilla or intracavitary irradiation was effective in eradicating the residue of the tumor. Thus, no total resection of the maxilla has been required even in advanced cases since May 1965. This therapy reduced the rate of local recurrences and consequently has been improving survival rate. The curtailment of surgery increased the number of patients who rehabilitated successfully and were able to return to their occupations soon after the treatment.

The Capillary in the human cochlea

The capillary area of eighteen aged human cochleas was studied using an alkaline phosphatasc staining method. The technique is described in detail. Modes of capillary branching in the spiral lamina were different from turn to turn. The vas spirale, a loop capillary vessel beneath the tunnel of Corti, was long in the basal turn and short in the upper turn. The spiral lamina of the upper turn was more vascularized than that of the basal turn. A morphometric measurement showed that the ratio of capillary density at the areas of 25 mm and 5 mm was 1.5. The significance of the findings is discussed in connection with the vulnerability of the basal turn of the cochlea in sensori-neural deafness.

Presbyacusis A Histological-histochemical Study of the Human Cochlea

The cochleas of thirty aged people were studied histologically as well as histochemically to demonstrate the pathology of sensori-neural elements in the organ of Corti. Loss of sensory cells was found to be most severe near the basal end of the cochlea. Nerve fibers, both afferent and efferent, showed marked changes near the basal end and less towards the apex. These changes consisted of missing, and various processes of degeneration of, nerve fibers. Changes of sensori-neural elements seen from the apex to the basal end were indicative of a process of degeneration of the individual element.

XX An Experimental Study of Central Motor Innervation of the Laryngeal Muscles in the Cat

It is reasonable to consider that the functions of the larynx depend upon reflex and intentional movement of the laryngeal muscles which is well-organized by voluntary and autonomic innervation. It is generally accepted that the larynx is supplied with both motor and sensory nerve fibers by two pairs of nerves: superior and inferior laryngeal nerves. However, the central mechanism of the innervation of the laryngeal muscles is one of the most obscure problems in the field of laryngology.

XXVI A Consideration on the Circulation of the Perilymph An Experimental Study

A route of circulation of the perilymph in the cochlea was suggested. The perilymph was absorbed in the lower spiral ligament near the basement membrane. The perivascular space around the venule and vein plays an important role as a channel to convey fluid out of the perilymphatic space.A route of circulation of the perilymph in the cochlea was suggested. The perilymph was absorbed in the lower spiral ligament near the basement membrane. The perivascular space around the venule and vein plays an important role as a channel to convey fluid out of the perilymphatic space.

Histopathological changes in the auditory pathway in cases of fatal head injury.

In five patients who died 24 hours, 3 days, 8 days, a month, and 4 months, respectively, after head trauma, the brain and the brain stem were histopathologically examined with special reference to the auditory pathway and the cortex. In one case who survived for 3 days, hemorrhage in the brain stem affected the inferior colliculus, lateral lemniscus, and superior olivary nucleus. In another case who survived for 4 months, multiple softening foci scattered in the brain stem affected also the inferior colliculus, lateral lemniscus, and superior olivary nucleus. In remaining three cases, hemorrhage in varying degrees was observed in the brain stem and the brain. From these findings it was assumed that in case of head trauma, hearing impairment may possibly be caused by retrolabyrinthine lesion.

Spontaneous nystagmus as a sign of clinical significance.

In the examination of patients suffering from vertigo of loss-of-balance, stress should be put on demonstration and identification of spontaneous nystagmus. the order of applied test-procedures of spontaneous nystagmus is based upon experience gained in examining patients in our clinic.The applied order is as follows:-1)examination of spontaneous nystagmus with the eyes open2)examination of spontaneous nystagmus behind Frenzels spectacles3)examination of spontaneous nystagmus by using electronystagmo-graphy4)optokinetic pattern test (OKP test)5)mobilization of spontaneous nystagmus through optokinetic stimulation.The first four above procedures have their respective importance and should be performed as a matter of routine in all vertigo or loss-of-balance cases. the third, fourth and fifth tests are performed by using electronystagmography, the clinical significance of which cannot be overemphasized in optokinetic Dattern test, as i t is termed in our clinic, is helpful both for differentiation of spont...