Ileana I. Rodriguez

Sandresolides A and B: novel nor-diterpenes from the sea whip Pseudopterogorgia elisabethae (Bayer)

Abstract A recent chemical study of the hexane extracts of Pseudopterogorgia elisabethae led to the isolation of two novel nor -diterpenes 1 and 2 , in addition to a known sesquiterpene 3 . The structures were established by spectroscopic and X-ray diffraction studies.

Aberrarone: A Gorgonian-Derived Diterpene from Pseudopterogorgia elisabethae

A marine metabolite based on a previously undescribed carbon skeleton, aberrarone (1), is reported as a natural product from the Caribbean sea whip, Pseudopterogorgia elisabethae. The molecular structure of the crystalline metabolite was established by spectral analysis and subsequently confirmed by X-ray crystallographic analysis. Aberrarone shows in vitro antimalarial activity against a chloroquine-resistant strain of the protozoan parasite Plasmodium falciparum.

Ileabethin: isolation and structure of a new class of perhydroacenaphthene diterpene from the Caribbean Sea Whip Pseudopterogorgia elisabethae (Bayer)

A recent chemical investigation of the hexane extract of a Colombian specimen of Pseudopterogorgia elisabethae (Bayer) has led to the isolation of ileabethin (1). This novel diterpene possesses a previously undescribed carbon skeleton which appears to be biosynthetically related to the serrulatane (biflorane) skeleton. The structure of 1 was elucidated after interpretation of its combined spectroscopic data.

Elisapterosins D and E: complex polycyclic diterpenes of the rare elisapterane class of natural products from the Caribbean sea whip Pseudopterogorgia elisabethae (Bayer)

From the hexane extracts of a Colombian specimen of Pseudopterogorgia elisabethae (Bayer) we have isolated elisapterosin D (2) and elisapterosin E (3), two structurally complex polycyclic diterpenes based on the rare elisapterane carbon skeleton. The structures of these scanty compounds were elucidated after interpretation of their combined spectroscopic data and NMR spectral comparisons with known elisapterane models.

2.11 – The Natural Products Chemistry of the Gorgonian Genus Pseudopterogorgia (Octocorallia: Gorgoniidae)

This chapter intends to provide a comprehensive review of the natural products chemistry of gorgonian octocorals of the genus Pseudopterogorgia from the beginning of 1968 to early 2009. The primary aim is to include all the marine natural products reported from this group of marine animals and to provide information regarding all of the gorgonian species from which these metabolites were isolated and to briefly describe their isolation, structure elucidation, and any type of biological activity they possess. Information on some of the pharmacologic and mechanistic studies, chemical ecology, biosynthesis, biogenetic interrelationships, and total synthesis of these compounds has been included. The chapter is loosely organized according by gorgonian species, and the compilation of natural products reported from each species is presented by structural type.

Structural characterization of Elisabatin B and Elisabatin C

AbstractX-ray structures of Elisabatin B (1) and Elisabatin C (2) have been determined. Crystal data for 1: Triclinic, P

Homopseudopteroxazole, a New Antimycobacterial Diterpene Alkaloid from Pseudopterogorgia elisabethae

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Elisabatins A and B: new amphilectane-type diterpenes from the West Indian sea whip Pseudopterogorgia elisabethae.

(No. 2), a = 7.528(2) Å, b = 9.404(2) Å, c = 11.414(2) Å, α = 75.363(3)°, β = 86.668(4)°, γ = 89.683(4)°, and Z = 2. Crystal data for 2: Monoclinic, P21/c (No. 14), a = 8.242(2) Å, b = 14.870(2) Å, c = 13.060(2) Å, β = 101.458(3)°, and Z = 4. Both compounds are highly unsaturated leading to extended aromatic conjugation. They show different intermolecular O–H⋅⋅⋅O hydrogen bonds, via which 1 forms dimers, and 2 zig-zag polymeric chains.