Illhoi Yoo

A Systematic Review of Healthcare Applications for Smartphones

BackgroundAdvanced mobile communications and portable computation are now combined in handheld devices called “smartphones”, which are also capable of running third-party software. The number of smartphone users is growing rapidly, including among healthcare professionals. The purpose of this study was to classify smartphone-based healthcare technologies as discussed in academic literature according to their functionalities, and summarize articles in each category.MethodsIn April 2011, MEDLINE was searched to identify articles that discussed the design, development, evaluation, or use of smartphone-based software for healthcare professionals, medical or nursing students, or patients. A total of 55 articles discussing 83 applications were selected for this study from 2,894 articles initially obtained from the MEDLINE searches.ResultsA total of 83 applications were documented: 57 applications for healthcare professionals focusing on disease diagnosis (21), drug reference (6), medical calculators (8), literature search (6), clinical communication (3), Hospital Information System (HIS) client applications (4), medical training (2) and general healthcare applications (7); 11 applications for medical or nursing students focusing on medical education; and 15 applications for patients focusing on disease management with chronic illness (6), ENT-related (4), fall-related (3), and two other conditions (2). The disease diagnosis, drug reference, and medical calculator applications were reported as most useful by healthcare professionals and medical or nursing students.ConclusionsMany medical applications for smartphones have been developed and widely used by health professionals and patients. The use of smartphones is getting more attention in healthcare day by day. Medical applications make smartphones useful tools in the practice of evidence-based medicine at the point of care, in addition to their use in mobile clinical communication. Also, smartphones can play a very important role in patient education, disease self-management, and remote monitoring of patients.

Data Mining in Healthcare and Biomedicine: A Survey of the Literature

As a new concept that emerged in the middle of 1990’s, data mining can help researchers gain both novel and deep insights and can facilitate unprecedented understanding of large biomedical datasets. Data mining can uncover new biomedical and healthcare knowledge for clinical and administrative decision making as well as generate scientific hypotheses from large experimental data, clinical databases, and/or biomedical literature. This review first introduces data mining in general (e.g., the background, definition, and process of data mining), discusses the major differences between statistics and data mining and then speaks to the uniqueness of data mining in the biomedical and healthcare fields. A brief summarization of various data mining algorithms used for classification, clustering, and association as well as their respective advantages and drawbacks is also presented. Suggested guidelines on how to use data mining algorithms in each area of classification, clustering, and association are offered along with three examples of how data mining has been used in the healthcare industry. Given the successful application of data mining by health related organizations that has helped to predict health insurance fraud and under-diagnosed patients, and identify and classify at-risk people in terms of health with the goal of reducing healthcare cost, we introduce how data mining technologies (in each area of classification, clustering, and association) have been used for a multitude of purposes, including research in the biomedical and healthcare fields. A discussion of the technologies available to enable the prediction of healthcare costs (including length of hospital stay), disease diagnosis and prognosis, and the discovery of hidden biomedical and healthcare patterns from related databases is offered along with a discussion of the use of data mining to discover such relationships as those between health conditions and a disease, relationships among diseases, and relationships among drugs. The article concludes with a discussion of the problems that hamper the clinical use of data mining by health professionals.

A coherent graph-based semantic clustering and summarization approach for biomedical literature and a new summarization evaluation method

BackgroundA huge amount of biomedical textual information has been produced and collected in MEDLINE for decades. In order to easily utilize biomedical information in the free text, document clustering and text summarization together are used as a solution for text information overload problem. In this paper, we introduce a coherent graph-based semantic clustering and summarization approach for biomedical literature.ResultsOur extensive experimental results show the approach shows 45% cluster quality improvement and 72% clustering reliability improvement, in terms of misclassification index, over Bisecting K-means as a leading document clustering approach. In addition, our approach provides concise but rich text summary in key concepts and sentences.ConclusionOur coherent biomedical literature clustering and summarization approach that takes advantage of ontology-enriched graphical representations significantly improves the quality of document clusters and understandability of documents through summaries.

A comprehensive comparison study of document clustering for a biomedical digital library MEDLINE

Document clustering has been used for better document retrieval, document browsing, and text mining in digital library. In this paper, we perform a comprehensive comparison study of various document clustering approaches such as three hierarchical methods (single-link, complete-link, and complete link), Bisecting K-means, K-means, and suffix tree clustering in terms of the efficiency, the effectiveness, and the scalability. In addition, we apply a domain ontology to document clustering to investigate if the ontology such as MeSH improves clustering qualify for MEDLINE articles. Because an ontology is a formal, explicit specification of a shared conceptualization for a domain of interest, the use of ontologies is a natural way to solve traditional information retrieval problems such as synonym/hypernym/ hyponym problems. We conducted fairly extensive experiments based on different evaluation metrics such as misclassification index, F-measure, cluster purity, and entropy on very large article sets from MEDLINE, the largest biomedical digital library in biomedicine

Integration of semantic-based bipartite graph representation and mutual refinement strategy for biomedical literature clustering

We introduce a novel document clustering approach that overcomes those problems by combining a semantic-based bipartite graph representation and a mutual refinement strategy. The primary contributions of this paper are the following. First, we introduce a new representation of documents using a bipartite graph between documents and co-occurrence concepts in the documents. Second, we show how to enhance clustering quality by applying the mutual refinement strategy to the initial clustering results. Third, through the experiments on MEDLINE documents, we show that our integrated method significantly enhances cluster quality and clustering reliability compared to existing clustering methods. Our approach improves on the average 29.5 cluster quality and 26.3 clustering reliability, in terms of misclassification index, over Bisecting K-means with the best parameters.

Data-Mining Technologies for Diabetes: A Systematic Review

Background: The objective of this study is to conduct a systematic review of applications of data-mining techniques in the field of diabetes research. Method: We searched the MEDLINE database through PubMed. We initially identified 31 articles by the search, and selected 17 articles representing various data-mining methods used for diabetes research. Our main interest was to identify research goals, diabetes types, data sets, data-mining methods, data-mining software and technologies, and outcomes. Results: The applications of data-mining techniques in the selected articles were useful for extracting valuable knowledge and generating new hypothesis for further scientific research/experimentation and improving health care for diabetes patients. The results could be used for both scientific research and real-life practice to improve the quality of health care diabetes patients. Conclusions: Data mining has played an important role in diabetes research. Data mining would be a valuable asset for diabetes researchers because it can unearth hidden knowledge from a huge amount of diabetes-related data. We believe that data mining can significantly help diabetes research and ultimately improve the quality of health care for diabetes patients.

Ontology-Based Scalable and Portable Information Extraction System to Extract Biological Knowledge from Huge Collection of Biomedical Web Documents

Automated discovery and extraction of biological knowledge from biomedical web documents has become essential because of the enormous amount of biomedical literature published each year. In this paper we present an ontology-based scalable and portable information extraction system to automatically extract biological knowledge from huge collection of online biomedical web documents. Our method integrates ontology-based semantic tagging, information extraction and data mining together, automatically learns the patterns based on a few user seed tuples, and then extract new tuples from the biomedical web documents based on the discovered patterns. A novel system SPIE (Scalable and Portable Information Extraction) is implemented and tested on the PuBMed to find the chromatin protein-protein interaction and the experimental results indicate our approach is very effective in extracting biological knowledge from huge collection of biomedical web documents.

Biomedical Ontology MeSH Improves Document Clustering Qualify on MEDLINE Articles: A Comparison Study

Document clustering has been used for better document retrieval, document browsing, and text mining. In this paper, we investigate if biomedical ontology MeSH improves the clustering quality for MEDLINE articles. For this investigation, we perform a comprehensive comparison study of various document clustering approaches such as hierarchical clustering methods (single-link, complete-link, and complete link), bisecting K-means, K-means, and suffix tree clustering (STC) in terms of efficiency, effectiveness, and scalability. According to our experiment results, biomedical ontology MeSH significantly enhances clustering quality on biomedical documents. In addition, our results show that decent document clustering approaches, such as bisecting K-means, K-means and STC, gains some benefit from MeSH ontology while hierarchical algorithms showing the poorest clustering quality do not reap the benefit of MeSH ontology

Extracting and mining protein-protein interaction network from biomedical literature

We present a biomedical literature data mining system SPIE-DM (Scalable and Portable Information Extraction and Data Mining) to extract and mine the protein-protein interaction network from biomedical literature such as MedLine. SPIE-DM consists of two phases: in phase 1, we develop a scalable and portable ie method (SPIE) to extract the protein-protein interaction from the biomedical literature. These extracted protein-protein interactions form a scale-free network graph. In phase 2, we apply a novel clustering method SFCluster to mine the protein-protein interaction network. The clusters in the network graph represent some potential protein complexes, which are very important for biologist to study the protein functionality. The clustering algorithm considers the characteristics of the scale-free network graphs and is based on the local density of the vertex and its neighborhood functions that can be used to find more meaningful clusters at different density levels. The experiments of SPIE-DM on around 1600 chromatin proteins indicate that our system is very promising for extracting and mining from biomedical literature databases.

A Study on Pubmed Search Tag Usage Pattern: Association Rule Mining of a Full-day Pubmed Query Log

BackgroundThe practice of evidence-based medicine requires efficient biomedical literature search such as PubMed/MEDLINE. Retrieval performance relies highly on the efficient use of search field tags. The purpose of this study was to analyze PubMed log data in order to understand the usage pattern of search tags by the end user in PubMed/MEDLINE search.MethodsA PubMed query log file was obtained from the National Library of Medicine containing anonymous user identification, timestamp, and query text. Inconsistent records were removed from the dataset and the search tags were extracted from the query texts. A total of 2,917,159 queries were selected for this study issued by a total of 613,061 users. The analysis of frequent co-occurrences and usage patterns of the search tags was conducted using an association mining algorithm.ResultsThe percentage of search tag usage was low (11.38% of the total queries) and only 2.95% of queries contained two or more tags. Three out of four users used no search tag and about two-third of them issued less than four queries. Among the queries containing at least one tagged search term, the average number of search tags was almost half of the number of total search terms. Navigational search tags are more frequently used than informational search tags. While no strong association was observed between informational and navigational tags, six (out of 19) informational tags and six (out of 29) navigational tags showed strong associations in PubMed searches.ConclusionsThe low percentage of search tag usage implies that PubMed/MEDLINE users do not utilize the features of PubMed/MEDLINE widely or they are not aware of such features or solely depend on the high recall focused query translation by the PubMed’s Automatic Term Mapping. The users need further education and interactive search application for effective use of the search tags in order to fulfill their biomedical information needs from PubMed/MEDLINE.