Ilyas Atar

Effect of Mechanical Dyssynchrony and Cardiac Resynchronization Therapy on Left Ventricular Rotational Mechanics

Alterations in rotational mechanics can bring new aspects to the understanding of left ventricular (LV) dyssynchrony. The aims of this study were to investigate LV rotational mechanics in candidates for cardiac resynchronization therapy (CRT) and to assess the effect of CRT by speckle-tracking echocardiography. Fifty-four patients with heart failure and 33 healthy controls were studied. Thirty-three underwent CRT. Speckle tracking was applied to short- and long-axis views. Radial and longitudinal dyssynchrony were assessed as previously defined. Apical and basal rotations were measured as the average angular displacement about the LV central axis. LV twist and torsion were then calculated. Peak apical and basal rotation, peak LV twist and torsion, apical and basal rotation at aortic valve closure (AVC), and LV twist and torsion at AVC were significantly lower in patients than controls. Apical-basal rotation delay and AVC-to-peak LV twist interval were longer in patients and associated with decreased peak LV twist and LV twist at AVC, respectively. In patients, rotational indexes, particularly LV twist and torsion, were correlated strongly with radial dyssynchrony. LV torsion (cutoff 0.1 degrees /cm) and twist (cutoff 1 degrees ) at AVC had the highest sensitivity (90%) and specificity (77%) to predict CRT responders among all other parameters, including radial and longitudinal dyssynchrony. In conclusion, LV dyssynchrony is associated with discoordinate rotation of the apical and basal regions, which in turn significantly decreases peak LV twist and torsion and LV twist and torsion at AVC. CRT significantly restored the altered rotational mechanics in responders. These parameters have potential for predicting responders to CRT.

Impaired coronary flow reserve in patients with metabolic syndrome

BACKGROUND Metabolic syndrome (MetS) is a strong predictor of cardiovascular events. Coronary flow reserve (CFR), as determined by transthoracic echocardiography, is an indicator of microvascular function. In this study, we sought to determine whether CFR is impaired in patients with MetS without clinical coronary heart disease. METHODS Thirty-three patients with MetS (mean age, 67+/-8 years) and 35 age- and sex-matched controls were studied prospectively. Transthoracic two-dimensional and Doppler echocardiography was performed on all patients. Baseline and hyperemic (after dipyridamole infusion) coronary flow rates were measured using pulsed Doppler echocardiography. CFR was calculated as the ratio of hyperemic to baseline diastolic peak velocities. RESULTS There was no difference with regard to baseline systolic and diastolic coronary flow rates in patients with MetS compared with control subjects (19.9+/-3.1cm/s vs. 19.7+/-2.9cm/s, P>.05; and 27.7+/-4.2cm/s vs. 27.1+/-3.6cm/s, P>.05, respectively). Hyperemic diastolic flow and CFR were significantly lower in patients with MetS than in controls (61.7+/-9.4cm/s vs. 70.2+/-9.2cm/s, P<.0001; and 2.2+/-0.5 vs. 2.6+/-0.4, P=.001, respectively). In a logistic regression analysis that included age, sex, body mass index, hypertension, and dyslipidemia and MetS, MetS was the only predictor of a CFR<2.5 (P=.007, OR=6.1, 95% CI: 1.6-23.3). CONCLUSION In conclusion, CFR is impaired in patients with MetS suggesting that coronary microvascular dysfunction, an early finding of atherosclerosis, is present in this patient population. Metabolic syndrome is associated with a CFR<2.5.

Prevalence and Predictors of Arrhythmia in End Stage Renal Disease Patients on Hemodialysis

Background. Sudden death is common in end-stage renal disease (ESRD). Cardiac arrhythmia is observed frequently in patients with ESRD and is thought to be responsible for this high rate of sudden death. This study investigated the prevalence and the predictors of arrhythmia in patients on maintenance dialysis. Methods. Ninety-four patients on hemodialysis program were enrolled in the study. Routine laboratory results were noted. Arrhythmia, periods of silent ischemia, and heart-rate variability analyses were obtained from 24-hour Holter monitor recordings. Corrected QT (QTc) dispersion was calculated from 12-lead surface EKG. Echocardiographic and tissue Doppler examinations were performed on interdialytic days as well. Ventricular arrhythmia was classified according to Lown classification; classes 3 and above were accepted as complex ventricular arrhythmia (CVA). Results. The mean age was 52.5±13.2 years; 44 (46.8%) were women. Ventricular premature contractions were detected in 80 (85.1%) patients, of whom 35 (37.2%) were classified as complex ventricular arrhythmia (CVA). Coronary artery disease, hypertension, and QTc dispersion appeared as independent factors predictive of CVA development. Atrial premature contractions (APC) were detected in 53 patients (56.4%) and supraventricular arrhythmia in 15 (16%) patients; all were identified as atrial fibrillation. Duration of dialysis therapy was found as an independent predictor of APC. Conclusion. Arrhythmia is frequently observed in ESRD patients receiving hemodialysis and may be responsible for the high rate of sudden mortality. Hypertension, CAD, and QTc dispersion are independent predictors of CVA, and duration of dialysis therapy is an independent factor affecting APC development in these patients.

Right Ventricular Function Is a Determinant of Long-Term Survival after Cardiac Resynchronization Therapy

BACKGROUND Right ventricular (RV) dysfunction is a marker of poor prognosis in patients with heart failure. The aim of this study was to investigate the impact of RV function on the long-term outcomes of patients undergoing cardiac resynchronization therapy (CRT). METHODS A total of 120 consecutive patients treated with CRT according to guideline criteria were followed over 5 years. Comprehensive echocardiographic analyses of RV function and radial and longitudinal mechanical left ventricular dyssynchrony were performed at baseline and 6 months after implantation. RV function was evaluated by two-dimensional longitudinal strain of the free wall, fractional area change, tricuspid annular plane systolic excursion, and tricuspid annular systolic velocity. Long-term follow-up events were defined as all-cause mortality, heart transplantation, or assist device implantation. RESULTS Long-term events occurred in 38 patients. Among the studied variables for RV function, RV strain < 18% had the highest sensitivity (79%) and specificity (84%) to predict a poor outcome after CRT (area under curve, 0.821; P < .0001). When adjusted for confounding baseline variables of ischemic etiology, mechanical dyssynchrony, left ventricular end-systolic volume, mitral regurgitation, and medical therapy, RV dysfunction remained independently associated with outcomes, indicating a 5.7-fold increased risk for hard events (P < .0001). CONCLUSIONS Preserved RV function as assessed by speckle-tracking strain imaging appears to be an independent predictor of long-term event-free survival after CRT.

Does pravastatin therapy affect cardiac enzyme levels after percutaneous coronary intervention

Serum cardiac enzyme elevation after percutaneous coronary intervention (PCI), a relatively common complication, is a prognostic determinant of long-term outcome in patients who undergo these procedures. Statins are postulated to reduce such complications. This study investigated the short-term effects of pravastatin on serum creatine kinase myocardial isoform (CK-MB) and serum cardiac troponin I (cTpI) levels after elective PCI. Of 93 patients studied, 72 (77.4%) were men, and 21 (22.6%) were women (mean age, 58.9±11.0 y). Patients were randomly divided into 3 groups before they underwent elective PCI. Preoperatively, group 1 patients (n=30) received pravastatin 10 mg/d, and group 2 patients (n=29) received pravastatin 40 mg/d. Control group patients (n=34) received no lipid-lowering medication. Serum CK-MB and serum cTpI levels were measured preoperatively and then again at 6, 24, and 36 h postoperatively. Demographic features of patients and characteristics of the PCI procedure, including number of vessels/lesions and duration and number of inflations, did not differ among groups (P>.05). Mean serum CK-MB and serum cTpI levels were significantly increased after PCI in all patients (P<.001). When compared with control group patients, those given pravastatin did not experience significantly lowered postprocedural serum CK-MB or serum cTpI levels (P>.05). Preprocedural pravastatin therapy at dosages of 10 mg/d and 40 mg/d seems inadequate for preventing serum cardiac enzyme elevations during short-term follow-up after PCI. Additional research on this topic is recommended.

Adenosine‐Induced Ventricular Arrhythmias in Patients with Supraventricular Tachycardias

Background: Adenosine is widely used for the diagnosis and the termination of supraventricular arrhythmias. There are many case reports and few series about the proarrhythmic potential of adenosine. We sought to evaluate the proarrhythmic potential of adenosine used to terminate the supraventricular arrhythmias.

Effect of right ventricular pacing lead on left ventricular dyssynchrony in patients receiving cardiac resynchronization therapy.

Right ventricular (RV) pacing-induced left ventricular (LV) dyssynchrony can be 1 reason of nonresponse to cardiac resynchronization therapy (CRT) by potentially interfering with spontaneous dyssynchrony. We investigated the effect of the RV pacing lead on LV dyssynchrony in patients receiving CRT. LV radial dyssynchrony was assessed in a 16-segment model by using the novel speckle-tracking imaging before CRT and after the procedure, when the device was randomized to biventricular and RV pacing with crossover after 48 hours. LV lead tip was localized under fluoroscopic guidance. Of 43 patients, 30 (70%) acutely responded to CRT by a decrease in end-systolic volume >10%. RV pacing did not significantly increase the magnitude but altered the pattern of intraventricular dyssynchrony in the overall study group. During RV pacing, major shifts in the latest activated region occurred in 20 patients. However, LV radial dyssynchrony during spontaneous rhythm, but not the 1 induced by RV pacing, predicted response to CRT. When lead localization was optimal according to spontaneous dyssynchrony, response rate was 89% compared with 50% when lead localization was not optimal (p = 0.01). In contrast, when lead localization was optimal according to RV pacing-induced dyssynchrony, response rate was 81% compared with 67% when lead localization was not optimal (p = NS). In conclusion, RV apical pacing can alter the pattern of spontaneous LV dyssynchrony in patients receiving CRT. However, this alteration does not detract from the value of assessing LV dyssynchrony during spontaneous rhythm to predict responders to CRT.

Implantation of submammary implantable cardioverter defibrillators.

Implantable cardioverter defibrillators (ICDs) are routinely placed in the left pectoral area using a transvenous approach. This approach may result in poor cosmetic outcome and cause psychological problems, especially in younger patients. To avoid this, several alternative implantation techniques have been developed. For cosmetic reasons, we used a submammary technique to implant ICDs into three young women. Apart from defibrillation threshold testing, the procedures were performed under local anesthesia. Threshold testing was done under general anesthesia. Appropriate defibrillation thresholds were obtained in all three cases, and all the patients tolerated the procedure well. There were no complications in a mean of 22 months of follow‐up, and the cosmetic results were very good.(PACE 2004; 27[Pt. I]:779–782)

Effects of a beta blocker and spironolactone on plasma homocysteine levels.

Homocysteine is an independent risk factor for taking no medication. A total of 65 patients (44 atherosclerosis [1–3]. The main effect of homocyfemales and 21 males) completed the protocol. steine on the cardiovascular system is endothelial Patients were randomly assigned to receive either  injury [3–5]. spironolactone 50 mg/day (Aldactone, Ali Raif , Recent investigations have documented higher Istanbul, Turkey) or metoprolol 100 mg/day (Beloc  homocysteine levels in hypertensive patients [6,7]. ZOC, AstraZeneca , Sweden). Each individual was Sharabi et al. [8] studied hypertensives with atherotre-evaluated at 1 and 5 months of treatment. If blood hrombosis, and found that homocysteine levels were pressure was above normal at any of the re-check lower in those who were on beta-blocker therapy. exams, the drug dosage was doubled. Patients whose Another study [9] showed that beta-adrenergic reblood pressures could not be controlled were exceptor stimulation increased the secretion of cluded. homocysteinic acid in astrocyte cultures, and that this Homocysteine was measured by an enzyme im effect was diminished by beta blocker administration. munoassay (Axis Biochemical ASA , Oslo, Norway). Morrow et al. [10] studied the long-term effects of Plasma folate and vitamin B12 levels were measured diuretic treatment on plasma homocysteine, vitamin by chemiluminescent enzyme immunoassay in an  B12, vitamin B6, and folate levels, and demonstrated immulite autoanalyzer (DPC , Los Angeles, CA). a significant increase in homocysteine levels. A t-test was used for quantitative and chi-square We found no reports that discussed the influence of test was used for qualitative variables. Changes in beta blocker on homocysteine levels. We planned to homocysteine levels were evaluated using the pairedinvestigate this and also examined the effects of sample t-test. P values ,0.05 were accepted as spironolactone. significant. From May 2000 through December 2000, we The mean age was 49.469.7 (32–71 years). There enrolled newly diagnosed adult patients with mild to were 41 patients in the metoprolol and 24 in the moderate hypertension. Eligible patients had no spironolactone group. The baseline homocysteine systemic disease apart from hypertension, and were levels were similar (13.564.4 and 13.668.3 mmol / l). Of the 24 patients in the spironolactone group, 14 (58.3%) were able to maintain normal blood pressure *Corresponding author. Tel.: 190-312-212-6868; fax: 190-312-440on a 50-mg/day dosage, and 10 (41.7%) had their 7735. E-mail address: mkorkmaz@isbank.net.tr (M.E. Korkmaz). dosage increased. As shown in Fig. 1, this group’s

Coronary microvascular function in patients with isolated systolic and combined systolic/diastolic hypertension.

J Clin Hypertens (Greenwich). 2012;14:871–876. ©2012 Wiley Periodicals, Inc.