Iman Mohasseb

Continuation of dual anti-platelet therapy after drug-eluting stents in primary angioplasty beyond 12 months

In this correspondence we discuss the results of the meta-analysis by De Luca et al. (2012) in the Archives of Internal Medicine which found that late myocardial reinfarction and stent thrombosis is more common in drug-eluting stents than in bare-metal stents. We discuss the clinical implications of this paper for dual anti-platelet therapy which did not receive sufficient attention in the original publication and the accompanying editorial.

1161-181 Regular Exercise Improves Risk Profile and Motor Development in Early Childhood

tolic BP, mean arterial pressure (MAP), total cholesterol, HDL, and LDL, between highand low CRP groups. High CRP patients did however demonstrate higher BMI (+4%;p=0.02), triglycerides (+13%; p=0.07), %fat (+6%; p=0.01), resting heart rate (+6%;p=0.004) as well as a lower peak VO2 (-9%; p<0.0001) respectively.Results: Following CRET, both high and low CRP groups exhibited statistical improve-ments in %fat (-3.0%, -4.3%), HDL (+7.3%, +7.1%), triglycerides (-12.1%, -8.2%) andpeakVO2 (+11.0%, +8.8%) respectively. Systolic, diastolic and MAP improved in patientswith low CRP but did not change in high CRP patients (Table).Conclusion: Therapeutic lifestyle change implemented through CRET improves most CVrisk factors. High levels of inflammation, however, appear to blunt the hemodynamicimprovements normally associated with CRET.