Imran Malik

Metronidazole Esters: A New Class of Antiglycation Agents

A series of metronidazole ester derivatives 1-34 has been synthesized with the aim of developing new leads with antiglycation activity. The in vitro evaluation of antiglycation potential of 1-34 showed that the ester derivatives 28, 16, and 3 have IC(50) values 218.97 ± 2.5, 245.3 ± 5.1, and 278.6 ± 0.8 µM, respectively, comparable to the standard agent, rutin (IC(50) = 294.5 ± 1.50 µM). The study identifies a new class of potent antiglycation agents. A structure-activity relationship has also been evaluated. All the compounds were characterized by using spectroscopic techniques, including (1)H NMR, IR, and EI-MS.

Synthesis of 7,8-Diarylflavonesby Site-Selective Suzuki-Miyaura Reactions

7,8-Diarylflavones were prepared by Suzuki―Miyaura reactions of the bis(triflate) of 7,8-dihydroxyflavone. The first attack proceeded with very good site selectivity at position 7, due to steric and electronic reasons.

Formiside and seco-formiside: lignin glycosides from leaves of Clerodendrum formicarum Gürke (Lamiaceae) from Cameroon

Abstract The ethanol soluble part of the leaves of Clerodendrum formicarum, a Lameacious plant of Cameroon, afforded two new lignin glycosides named formiside and seco-formiside. Structures of both the isolated constituents have been elucidated with the aid of 1D and 2D NMR spectroscopic techniques.