In Goo Lee
Catholic University of Korea
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Publication
Featured researches published by In Goo Lee.
Korean Journal of Pediatrics | 2013
Young-Ah Youn; In Kyung Sung; In Goo Lee
Brain insults, including neurotrauma, infection, and perinatal injuries such as hypoxic ischemic encephalopathy, generate inflammation in the brain. These inflammatory cascades induce a wide spectrum of cytokines, which can cause neuron degeneration, have neurotoxic effects on brain tissue, and lead to the development of seizures, even if they are subclinical and occur at birth. Cytokines are secreted by the glial cells of the central nervous system and they function as immune system mediators. Cytokines can be proinflammatory or anti-inflammatory. Interleukin (IL)-1β and IL-8 are proinflammatory cytokines that activate additional cytokine cascades and increase seizure susceptibility and organ damage, whereas IL-1 receptor antagonist and IL-10 act as anti-inflammatory cytokines that have protective and anticonvulsant effects. Therefore, the immune system and its associated inflammatory reactions appear to play an important role in brain damage. Whether cytokine release is relevant for the processes of epileptogenesis and antiepileptogenesis, and whether epileptogenesis could be prevented by immunomodulatory treatment should be addressed in future clinical studies. Furthermore, early detection of brain damage and early intervention are essential for the prevention of disease progression and further neurological complications. Therefore, cytokines might be useful as biomarkers for earlier detection of brain damage in high-risk infants.
Journal of the korean child neurology society | 2008
Sang Eun Kim; Hyon Gyu Kim; Young Hoon Kim; Byung Joon Choi; Hee Seong Hwang; Joong Hyun Bin; Seung Yun Chung; In Goo Lee
BMC Pediatrics | 2018
Ji Yoon Han; Chung Joon Moon; Young Ah Youn; In Kyung Sung; In Goo Lee
Pediatric Infection and Vaccine | 2014
Dae Eun Kim; Ramee Pae; E Young Bae; Ji Yoon Han; Seung Beom Han; Dae Chul Jeong; In Goo Lee; Jin Han Kang
Korean Journal of Perinatology | 2014
Ji Yoon Han; Jin Hee Lee; Sun Young Park; Chung Joon Moon; Young Ah Youn; In Kyung Sung; In Goo Lee
Journal of the korean child neurology society | 2014
Ra Mee Pae; Sun Young Park; Ji Yoon Han; Jae Wook Lee; Nack Gyun Chung; Bin Cho; In Goo Lee
Journal of the korean child neurology society | 2014
Joong Hyun Bin; Sun Young Park; Ji Yoon Han; Tae Hoon Eom; Seong Joon Kim; Young Hoon Kim; In Goo Lee; Seung Yun Chung
Journal of the korean child neurology society | 2010
Seong Koo Kim; Jin Young Lee; Young Hoon Kim; In Goo Lee
Journal of the korean child neurology society | 2010
Kyoung Soon Cho; Young Hoon Kim; Oh Joo Kwon; In Goo Lee
Korean Journal of Pediatrics | 2001
Joong Hyun Bin; Moon Young Song; In Goo Lee; Won Bae Lee; Byung Churl Lee