In-Sook Ahn
Handong Global University
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Publication
Featured researches published by In-Sook Ahn.
Experimental and Molecular Medicine | 2006
Bong-Hyuk Choi; In-Sook Ahn; Yu-Hee Kim; Ji-Won Park; So-Young Lee; Chang-Kee Hyun; Myoung-Sool Do
Berberine (BBR), an isoquinoline alkaloid, has a wide range of pharmacological effects, yet its exact mechanism is unknown. In order to understand the anti-adipogenic effect of BBR, we studied the change of expression of several adipogenic enzymes of 3T3-L1 cells by BBR treatment. First, we measured the change of leptin and glycerol in the medium of 3T3-L1 cells treated with 1 µM, 5 µM and 10 µM concentrations of BBR. We also measured the changes of adipogenic and lipolytic factors of 3T3-L1. In 3T3-L1 cells, both leptin and adipogenic factors (SREBP-1c, C/EBP-α, PPAR-γ, fatty acid synthase, acetyl-CoA carboxylase, acyl-CoA synthase and lipoprotein lipase) were reduced by BBR treatment. Glycerol secretion was increased, whereas expression of lipolytic enzymes (hormone-sensitive lipase and perilipin) mRNA was slightly decreased. Next, we measured the change of inflammation markers of 3T3-L1 cells by BBR treatment. This resulted in the down-regulation of mRNA level of inflammation markers such as TNF-α, IL-6, C- reactive protein and haptoglobin. Taken together, our data shows that BBR has both anti-adipogenic and anti-inflammatory effects on 3T3-L1 adipocytes, and the anti-adipogenic effect seems to be due to the down-regulation of adipogenic enzymes and transcription factors.
Journal of Medicinal Food | 2007
Sun-Hwa Kwon; In-Sook Ahn; Su-Ok Kim; Chang-Suk Kong; Hae Young Chung; Myoung-Sool Do; Kun-Young Park
Journal of Medicinal Food | 2006
In-Sook Ahn; Myoung-Sool Do; Su-Ok Kim; Hun-Soon Jung; Young-In Kim; Hye-Jung Kim; Kun-Young Park
Journal of Medicinal Food | 2006
In-Sook Ahn; Bong-Hyuk Choi; Jung-Heun Ha; Jae-Min Byun; Hyun-Gil Shin; Kun-Young Park; Myoung-Sool Do
Journal of Medicinal Food | 2004
Seong-Eui Hong; In-Sook Ahn; Hun-Soon Jung; D. Vernon Rayner; Myoung-Sool Do
The FASEB Journal | 2007
Kun-Young Park; Sun-Hwa Kwon; In-Sook Ahn; Su-Ok Kim; Chang-Suk Kong; Hae Young Chung; Myoung-Sool Do
Journal of Medicinal Food | 2007
Lan Yuan; In-Sook Ahn; Paul F. Davis
Journal of Food Science and Nutrition | 2006
In-Sook Ahn; Myoung-Sool Do; Bong-Hyuk Choi; Chang-Suk Kong; Su-Ok Kim; Min-Soo Han; Kun-Young Park
Journal of Food Science and Nutrition | 2003
Jung-Heun Ha; In-Sook Ahn; Jae-Min Byun; Hyung Ki Do; Sun-Young Jung; Jae-Hong Jeong; Klaus W.J. Wahle; Kun-Young Park; Myoung-Sool Do
Archive | 2010
Kun-Young Park; In-Sook Ahn