Indrani Banik

Asymmetric synthesis of anticancer β-lactams via Staudinger reaction: Utilization of chiral ketene from carbohydrate

We describe herein asymmetric synthesis of a novel anticancer beta-lactam following Staudinger reaction with chiral carbohydrate as the ketene component with an achiral imine. The in vitro cytotoxicity studies of these beta-lactams are also reported here.

Polycyclic aromatic compounds as anticancer agents: synthesis and biological evaluation of dibenzofluorene derivatives

Highly regioselective electrophilic substitution of dibenzofluorene was achieved and the nitro derivative was transformed to a variety of new anticancer agents.

Samarium-induced iodine-catalyzed reduction of imines: synthesis of amine derivatives

Abstract Samarium metal induced iodine-catalyzed reduction of the imines towards the synthesis of secondary amines was investigated. The imines derived from aromatic amines produced monoamines whereas imines from arylalkyl amines gave diamines in good yield.

Indium/Ammonium Chloride Mediated Selective Reduction of Aromatic Nitro Compounds: Practical Synthesis of 6-AminoChrysene

Abstract Reduction of aromatic and heteroaromatic nitro compounds to the corresponding amino compounds was achieved by indium/ammonium chloride induced reaction in aqueous ethanol. This method was extended for the preparation of large quantities of 6-aminochrysene in excellent yield.

A facile synthesis of oxazines by indium-induced reduction-rearrangement of the nitro β-lactams

An indium-induced reduction-rearrangement reaction of nitro-substituted β-lactams has been used for facile synthesis of oxazines in aqueous ethanol.

Cycloaddition of naphthalenyl and anthracenyl imines: Interesting aspects of the Staudinger reaction

Cycloaddition of imines derived from naphthalene and anthracene derivatives under Staudinger reaction conditions proceeded exceedingly well with remarkable control of stereochemistry to the corresponding β-lactams.

Synthesis of tricyclic β-lactams via palladium acetate-induced Heck reaction

Synthesis of tricyclic β-lactams via palladium acetate mediated cyclization of the unsaturated bromo β-lactam was accomplished in good yield.