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Featured researches published by Ines Colmegna.


Clinical Microbiology Reviews | 2004

HLA-B27-Associated Reactive Arthritis: Pathogenetic and Clinical Considerations

Ines Colmegna; Raquel Cuchacovich; Luis R. Espinoza

SUMMARY Current evidence supports the concept that reactive arthritis (ReA) is an immune-mediated synovitis resulting from slow bacterial infections and showing intra-articular persistence of viable, nonculturable bacteria and/or immunogenetic bacterial antigens synthesized by metabolically active bacteria residing in the joint and/or elsewhere in the body. The mechanisms that lead to the development of ReA are complex and basically involve an interaction between an arthritogenic agent and a predisposed host. The way in which a host accommodates to invasive facultative intracellular bacteria is the key to the development of ReA. The details of the molecular pathways that explain the articular and extra-articular manifestations of the disease are still under investigation. Several studies have been done to gain a better understanding of the pathogenesis of ReA; these constitute the basis for a more rational therapeutic approach to this disease.


Current Opinion in Rheumatology | 2006

Musculoskeletal and autoimmune manifestations of HIV, syphilis and tuberculosis.

Ines Colmegna; Jeffrey W. Koehler; Robert F. Garry; Luis R. Espinoza

Purpose of reviewThe HIV pandemic continues to increase at an alarming rate, and is the leading cause of death worldwide from a single pathogen. The number of HIV-1-infected individuals currently exceeds 40 million, the majority of whom live in the developing countries of Asia, sub-Saharan Africa and south America. In the past 5 years, there has concurrently been an increase in the reported cases of tuberculosis and primary and secondary syphilis. This review addresses the musculoskeletal and autoimmune manifestations associated with HIV, syphilis and tuberculosis infections or their treatments. Recent findingsDuring HIV infection the immune system becomes dysfunctional because of the coexistence of immunodeficiency and immune hyperactivity, and a disregulated production or activity of cytokines. Some of these mechanisms explain the development of rheumatic manifestations associated with HIV infection. Highly active antiretroviral therapy changes the course of HIV infection and the spectrum of the HIV-associated rheumatic manifestations. New syndromes such as the immune reconstitution inflammatory syndrome have emerged. HIV, tuberculosis and syphilis infections offer special epidemiological, clinical, and therapeutic challenges. SummaryThese observations highlight the complexity and multiplicity of the interactions between the pathogen and host that could result in the development of rheumatic manifestations.


Jcr-journal of Clinical Rheumatology | 2013

Assessing process of care in rheumatoid arthritis at McGill University hospitals.

Lisa Marina Li; Basile Tessier-Cloutier; Yafei Wang; Sasha Bernatsky; Evelyne Vinet; Henri A. Ménard; Pantelis Panopalis; Elizabeth Hazel; Michael Stein; Martin Cohen; Michael Starr; Christian A. Pineau; Marie-Ève Veilleux; Ines Colmegna

ObjectiveIn rheumatoid arthritis (RA), quality indicators (QIs) are tools used to measure process of care. This study aimed to assess performance of selected QIs from the 2004 Arthritis Foundation’s QI Set at 2 major sites of a university network of teaching hospitals. MethodsThe charts and electronic hospital records of 76 RA patients were audited to determine adherence to QIs. Logistic multivariate regression analyses were performed to investigate potential determinants of nonadherence and propose measures to facilitate better QI compliance, as a potential strategy towards RA care improvement. ResultsWe identified consistent observance of QIs mandating prescription of disease-modifying antirheumatic drug therapy for all patients, drug adjustment with disease activity, prednisone tapering, and bisphosphonate therapy if indicated for patients on glucocorticoids. However, there was either lack of documentation or true inconsistent adherence to QIs dealing with radiograph performance, functional capacity assessment, and screening for hepatitis and tuberculosis before commencement of methotrexate and biologic agents, respectively. For the specific QIs analyzed, we did not find any definite independent associations with the studied variables. ConclusionsOur findings indicate that while there is frequent evidence for adherence to certain RA quality care standards at our centers, there is less compliance to others. Strategies to optimize the performance or documentation of those found most lacking, namely, functional capacity and screening for specific drug contraindications, could improve patient care. Radiographic disease monitoring, while lacking, may represent a move toward other more sensitive methods of RA progression detection, such as joint ultrasound. The inclusion of patient- and physician-derived information could help elucidate the reasons underlying nonadherence.


Current Rheumatology Reports | 2005

Polyarteritis nodosa revisited.

Ines Colmegna; José A. Maldonado-Cocco


Microscopy Research and Technique | 2005

Involvement of human intracisternal A-type retroviral particles in autoimmunity

David M. Sander; Sara Szabo; William R. Gallaher; Jane E. Deas; James J. Thompson; Yan Cao; Hong Luo-Zhang; Leonita G. Liu; Ines Colmegna; Jeffery Koehler; Luis R. Espinoza; Steve S. Alexander; Darren J. Hart; Daniel M. Tom; Cesar D. Fermin; Jonathan J. Jaspan; Peter C. Kulakosky; Scott A. Tenenbaum; Russell B. Wilson; Robert F. Garry


Jcr-journal of Clinical Rheumatology | 2007

Piriformis pyomyositis with sciatica: an unrecognized complication of "unsafe" abortions.

Ines Colmegna; Maria Justiniano; Luis R. Espinoza; Carlos R Giménez


Current Rheumatology Reports | 2005

Recent advances in reactive arthritis

Ines Colmegna; Luis R. Espinoza


The Journal of Rheumatology | 2007

Spondyloarthritis as a presentation of gouty arthritis.

Maria Justiniano; Ines Colmegna; Raquel Cuchacovich; Luis R. Espinoza


The Journal of Rheumatology | 2008

Anti-20S proteasome antibodies in psoriatic arthritis.

Ines Colmegna; Bruno Sainz; Gustavo Citera; José A. Maldonado-Cocco; Robert F. Garry; Luis R. Espinoza


The Journal of Rheumatology | 2005

The proteasome and its implications in rheumatology

Ines Colmegna; Bruno Sainz; Robert F. Garry; Luis R. Espinoza

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Luis R. Espinoza

Louisiana State University

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Bruno Sainz

Spanish National Research Council

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James J. Thompson

University Medical Center New Orleans

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