Ira L. Rubin

The heart in progressive muscular dystrophy

Abstract 1. 1. The cardiac muscle is involved in a high percentage of cases in progressive muscular dystrophy. 2. 2. Clinically, the vast majority of these patients show no heart disease. Some patients, however, have congestive heart failure, while others have arrhythmias and tachycardias. 3. 3. Electrocardiographically, these patients showed short P-R intervals in five out of seventeen cases and abnormal Q waves in two cases.

Reduction of Cholesterol and Lipids in Man by Ethyl p-Chlorophenoxyisobutyrate

Excerpt Thorp and Waring (1) studied a series of aryloxyisobutyric acids in rats for their ability to lower the level of cholesterol and lipids in serum and liver and found the compounds with maxim...

Transient abnormal Q waves in the dog without myocardial infarction

Abstract Abnormal transitory Q waves in multiple leads were obtained in 7 of 19 dogs during experimental coronary artery ligation. The Q waves appeared within three minutes of ligation and disappeared within five minutes of release of ligation. Positional changes were eliminated as a cause of the Q wave. In 1 of the 5 dogs, a small subepicardial infarct was found at autopsy. In a second dog, a peripheral rim of necrotic muscle with some hemorrhage, probably too small to have caused Q waves, was present. The other 5 dogs showed no evidence of myocardial infarction. The data suggest that transient abnormal Q waves may result from electrophysiologic disturbance of the myocardium due to myocardial ischemia, in the presence or absence of myocardial infarction, and are indicative of myocardial infarction only when such Q waves persist for a protracted period.

Complete heart block with perforated interventricular septum following contusion of the chest

Abstract The case history of an apparently healthy young man who died following a nonpenetrating trauma to the chest from a steering-wheel accident is reported. Clinically, complete heart block was noted; pathologically, a ruptured interventricular septum was found.

Transitory Q waves simulating the Q wave of myocardial infarction.

Abstract 1.1. Two examples are presented of significant Q waves in the electrocardiograms in the absence of myocardial infarction on postmortem examination. 2.2. Two additional examples are presented of a significant diminution in the area of abnormal precordial Q wave occurring within several days following definite myocardial infarction. 3.3. Q waves may be transiently present when a metabolic insult is severe enough to produce electrophysiologic abnormalities of the myocardium unassociated with anatomic changes. These changes may be reversible despite their persistence over a period of several hours to several days.

Transitory Abnormal Q Waves During Bouts of Tachycardia

Abstract This is a report of a patient who had a healed myocardial infarct with a residual abnormal Q wave localized to one precordial lead. On four occasions during bouts of tachycardia broad areas of Q waves developed over the entire anterior and diaphragmatic regions of the heart associated with widening of the QRS complexes and elevation of the S-T segments and inversion of the T waves in many leads. With the cessation of the tachycardia the electrocardiogram reverted to the control pattern. The possible mechanism for these changes are (1) transient reversible ischemia of the myocardium resulting temporarily in the development of electrical inertness of the myocardium surrounding an old area of myocardial infarction; (2) aberrant conduction during tachycardia resulting in delay of depolarization of the myocardium surrounding the area of an old infarct and leading to broad areas of abnormal Q waves over the entire anterior and diaphragmatic portions of the heart; and (3) a combination of these mechanisms.

The esophageal lead in the diagnosis of tachycardias with aberrant ventricular conduction

Abstract 1. 1. Ventricular tachycardias may be simulated by supraventricular tachycardias having aberrant conduction, if the atrial complex is not clearly defined. 2. 2. The esophageal lead has been shown to be a simple, reliable method for demonstrating the atrial complex and its relationship to the ventricular complex. 3. 3. Cases of sinus tachycardia, atrial tachycardia, atrial flutter, atrial fibrillation, and ventricular tachycardia have been presented showing the value of the esophageal lead in making a definitive diagnosis in the presence of aberrant ventricular conduction.

The Electrocardiographic Recognition of Pacemaker Function and Failure

Abstract The recognition of proper and improper function of implanted electronic pacemakers utilized for cardiac stimulation may be aided by a knowledge of how they function and their effect on the...

The correlation between the Q waves of aVF and esophageal leads in the diagnosis of posterior myocardial infarction.

Excerpt The significance of a deep Q wave in standard Lead III as an aid to the diagnosis of posterior myocardial infarction was established by Pardee1in 1930. Since this time a deep Q3has been of ...

Simultaneous atrial flutter and ventricular tachycardia

Abstract A case of simultaneous ventricular tachycardia and atrial flutter is presented. The esophageal electrocardiogram clearly demonstrated the nature of the double rhythm which was not diagnosed from the routine 12-lead electrocardiogram. The etiology of the arrhythmias was most likely a recent myocardial infarction, although digitalis toxicity could not be excluded.