Irene Jarchum

Stem cells: It takes two to make an embryo

In vitro culture of mouse embryonic and extra-embryonic stem cells recapitulates embryogenesis.

Epigenetics: Tracing cell lineage with 5hmC

Single-cell 5hmC sequencing uncovers cell-to-cell differences in the two DNA strands of a given chromosome.

Proteomics: Proteome quantification compared

Careful benchmarking improves software methods for analyzing data-independent-acquisition mass spectrometry data.

Bioinformatics: RNase footprints re-examined

A computational tool enables the study of native nonribosomal RNA–protein complexes from ribosome profiling data.

Cell biology: Prostate cancer in 3D

Researchers grow genetically stable organoids from mouse and human prostate cells in the lab and establish patient-derived lines that model prostate cancer.