Iris Ka Man Leung
Alza
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Featured researches published by Iris Ka Man Leung.
Experimental Dermatology | 1997
Nancy K. Mize; Margaret Buttery; Nancy Ruis; Iris Ka Man Leung; Michel J. N. Cormier; Peter E. Daddona
Abstract The potential of an anti‐inflammatory peptide (antiflammin 1) to reduce irritation when delivered transdermally by iontophoresis was examined. A model drug irritant, chlorpromazine, was co‐delivered with and without antifiammin 1 by iontophoresis to hairless guinea pigs transdermally. Quantitative skin irritation measurements were obtained by monitoring erythema by skin color reflectance with the Minolta Chromameter. Antifiammin 1 delivered by iontophoresis significantly decreased, but did not eliminate, the erythema associated with co‐delivery of an irritating drug compound. Lesion formation was also reduced in the presence of antiflammin 1. In vitro flux across hairless guinea pig skin demonstrated no significant differences in flux of the irritant compound in the presence or absence of antiflammin 1. In vivo generation and efflux of the inflammation mediator Prostaglandin E2 increased during 24‐h application of irritant and was unchanged in the presence of antiflammin 1. This result is discussed with respect to recent evidence that antiflammins may act on the lipo‐oxygenase pathway. In summary, antiflammin 1, an antiflammatory peptide, can be delivered transdermally by iontophoresis with retention of its biological activity in vivo.
Archive | 1999
James B. Eckenhoff; Leslie A. Holladay; John J. Leonard; Iris Ka Man Leung; Sally A. Tao; Judy A Magruder; John P. Carr; Jeremy C. Wright
Archive | 1996
John P. Carr; James B. Eckenhoff; Leslie A. Holladay; John J. Leonard; Iris Ka Man Leung; Judy A Magruder; Sally A. Tao; Jeremy C. Wright
Archive | 1998
Michel J. N. Cormier; Iris Ka Man Leung; Anna Muchnik; Sara Lee Sendelbeck
Archive | 1998
Michel J. N. Cormier; Iris Ka Man Leung; Anna Muchnik; Sara Lee Sendelbeck
Archive | 1998
Michel J. N. Cormier; Iris Ka Man Leung; Anna Muchnik; Sara Lee Sendelbeck
Archive | 1998
Michel J. N. Cormier; Iris Ka Man Leung; Anna Muchnik; Sara Lee Sendelbeck
Archive | 1997
James B. Eckenhoff; Judy A Magruder; Leslie A. Holladay; Jr John Joseph Leonard; Iris Ka Man Leung; Sally A. Tao; John P. Carr; Jeremy C. Wright
Archive | 1996
James B. Eckenhoff; Leslie A. Holladay; John J. Leonard; Iris Ka Man Leung; Sally A. Tao; Judy A Magruder; John P. Carr; Jeremy C. Wright
Archive | 1996
Leslie A. Holladay; John J. Leonard; Iris Ka Man Leung; Sally A. Tao; Judy A Magruder; John P. Carr; Jeremy C. Wright; James B. Eckenhoff