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PLOS ONE | 2013

Epidemiology of Candidemia in Latin America: A Laboratory-Based Survey

Marcio Nucci; Flavio Queiroz-Telles; Tito Alvarado-Matute; Iris Nora Tiraboschi; Jorge Alberto Cortés; Jeannete Zurita; Manuel Guzman-Blanco; María Elena Santolaya; Luis Thompson; José Sifuentes-Osornio; Juan Echevarría; Arnaldo Lopes Colombo

Background The epidemiology of candidemia varies depending on the geographic region. Little is known about the epidemiology of candidemia in Latin America. Methods We conducted a 24-month laboratory-based survey of candidemia in 20 centers of seven Latin American countries. Incidence rates were calculated and the epidemiology of candidemia was characterized. Results Among 672 episodes of candidemia, 297 (44.2%) occurred in children (23.7% younger than 1 year), 36.2% in adults between 19 and 60 years old and 19.6% in elderly patients. The overall incidence was 1.18 cases per 1,000 admissions, and varied across countries, with the highest incidence in Colombia and the lowest in Chile. Candida albicans (37.6%), C. parapsilosis (26.5%) and C. tropicalis (17.6%) were the leading agents, with great variability in species distribution in the different countries. Most isolates were highly susceptible to fluconazole, voriconazole, amphotericin B and anidulafungin. Fluconazole was the most frequent agent used as primary treatment (65.8%), and the overall 30-day survival was 59.3%. Conclusions This first large epidemiologic study of candidemia in Latin America showed a high incidence of candidemia, high percentage of children, typical species distribution, with C. albicans, C. parapsilosis and C. tropicalis accounting for the majority of episodes, and low resistance rates.


Memorias Do Instituto Oswaldo Cruz | 2003

Species distribution and antifungal susceptibility profile of Candida spp. bloodstream isolates from Latin American hospitals.

Patricio Godoy; Iris Nora Tiraboschi; Luiz Carlos Severo; Beatriz Bustamante; Belinda Calvo; Leila Paula de Almeida; Daniel Archimedes da Matta; Arnaldo Lopes Colombo

From March 1999 to March 2000, we conducted a prospective multicenter study of candidemia involving five tertiary care hospitals from four countries in Latin America. Yeast isolates were identified by classical methods and the antifungal susceptibility profile was determined according to the National Committee for Clinical Laboratory Standards microbroth assay method. During a 12 month-period we were able to collect a total of 103 bloodstream isolates of Candida spp. C. albicans was the most frequently isolated species accounting for 42% of all isolates. Non-albicans Candida species strains accounted for 58% of all episodes of candidemia and were mostly represented by C. tropicalis (24.2%) and C. parapsilosis (21.3%). It is noteworthy that we were able to identify two cases of C. lusitaniae from different institutions. In our casuistic, non-albicans Candida species isolates related to candidemic episodes were susceptible to fluconazole. Continuously surveillance programs are needed in order to identify possible changes in the species distribution and antifungal susceptibility patterns of yeasts that may occurs after increasing the use of azoles in Latin American hospitals.


Revista Iberoamericana De Micologia | 2007

Brote de candidemia por Candida albicans en neonatología

Iris Nora Tiraboschi; Susana Carnovale; Ariana Benetucci; Norma Fernández; Isabel Kurlat; Mónica Foccoli; María Beatriz Lasala

Resumen El aislamiento de Candida albicans en tres pacientes (dos en hemocultivos) sugirio la existencia de un brote epidemico. En el caso 1 se aislo C. albicans de la placenta de la madre, asi como de una muestra de sangre del recien nacido tomada a los ocho dias de vida. Cuatro dias despues del diagnostico de esta candidemia, se aisla C. albicans en la punta del cateter de otro neonato (caso 2), y cinco dias despues en los hemocultivos de un tercer neonato (caso 3). Ante la sospecha de un brote epidemico, se investigo la existencia de colonizacion. Se tomaron mediante hisopo muestras de las manos del personal, la cuna del caso 3, la madre del caso 1 y los nueve neonatos internados. Cada hisopo se sembro en Chromagar Candida® y agar glucosado de Sabouraud. Los aislamientos de C. albicans recuperados fueron estudiados por RAPD. El estudio por RAPD mostro que los aislamientos de C. albicans de la placenta, los de los hemocultivos de los casos 1 y 3, y el de la punta de cateter del caso 2 eran genotipicamente identicos. Se aislo C. albicans de otros dos neonatos (boca e ingle en uno e ingle en el otro) y de la boca de la madre del caso 1. Esta ultima cepa y la de la boca del neonato colonizado estarian geneticamente relacionadas con la de los casos mencionados. No se aislo C. albicans del resto de los hisopos. Los aislamientos de C. albicans identicos permitieron suponer la trasmision horizontal a partir del caso 1, quien la habia adquirido congenitamente. Aunque los pacientes tengan factores de riesgo que justifiquen una infeccion por Candida, el aislamiento de C. albicans en varias muestras en un tiempo corto, debe hacer sospechar la posibilidad de la trasmision horizontal de la infeccion.


Revista Iberoamericana De Micologia | 2012

Fungemias en hospitales de la Ciudad de Buenos Aires, Argentina

Laura López Moral; Iris Nora Tiraboschi; Mariela Schijman; Mario H. Bianchi; Liliana Guelfand; Silvana Cataldi

BACKGROUND The incidence of fungi like pathogens in hospitals varies by regions. OBJECTIVES Our goal was not only to record the incidence and etiology of fungaemia, but also the change during the 4 years analysed, to determine the time of detection in automated blood culture and by lysis-centrifugation, and finally to assess the gender, age and underlying disease of the patients with fungaemia. METHODS An observational multicentre study of fungaemia was conducted in hospitals in the Mycology Network of Buenos Aires. RESULTS A total of 190,920 blood cultures were processed: 182,050 automated blood culture and 8,870 lysis-centrifugation. Fungi were recovered in 1,020 episodes. The overall incidence of fungaemia was 1.72/1,000 admissions; 683 episodes were due to Candida (68%), and 325 (32%) to other fungi: 214 Cryptococcus, 105 Histoplasma, 7 Rhodotorula, 5 Trichosporon, 2 Pichia, 2 Acremonium, one Saccharomyces and one Fusarium. The incidence of candidaemia was 1.15/1,000 admissions with a wide variation between centres (0.35 to 2.65). Most Candida isolates (97%) were detected in the first 2 days of incubation. Candida albicans was recovered in 43% of the episodes. In fungaemia other than candidaemia, the predominant fungi were Cryptococcus and Histoplasma capsulatum. CONCLUSIONS The incidence remained stable during the study period. Fungaemia by Candida were predominant. C. albicans was involved in less than a half of the episodes. The recovery of Cryptoccocus and H. capsulatum is strongly associated with HIV patients.


PLOS ONE | 2014

Surveillance of Candida spp bloodstream infections: epidemiological trends and risk factors of death in two Mexican tertiary care hospitals.

Dora E. Corzo-Leon; Tito Alvarado-Matute; Arnaldo Lopes Colombo; Patricia Cornejo-Juarez; Jorge Alberto Cortés; Juan Echevarría; Manuel Guzman-Blanco; Alejandro E. Macías; Marcio Nucci; Luis Ostrosky-Zeichner; Alfredo Ponce-de-León; Flavio Queiroz-Telles; María Elena Santolaya; Luis Thompson-Moya; Iris Nora Tiraboschi; Jeannete Zurita; José Sifuentes-Osornio

Introduction Larger populations at risk, broader use of antibiotics and longer hospital stays have impacted on the incidence of Candida sp. bloodstream infections (CBSI). Objective To determine clinical and epidemiologic characteristics of patients with CBSI in two tertiary care reference medical institutions in Mexico City. Design Prospective and observational laboratory-based surveillance study conducted from 07/2008 to 06/2010. Methods All patients with CBSI were included. Identification and antifungal susceptibility were performed using CLSI M27-A3 standard procedures. Frequencies, Mann-Whitney U test or T test were used as needed. Risk factors were determined with multivariable analysis and binary logistic regression analysis. Results CBSI represented 3.8% of nosocomial bloodstream infections. Cumulative incidence was 2.8 per 1000 discharges (incidence rate: 0.38 per 1000 patient-days). C. albicans was the predominant species (46%), followed by C. tropicalis (26%). C. glabrata was isolated from patients with diabetes (50%), and elderly patients. Sixty-four patients (86%) received antifungals. Amphotericin-B deoxycholate (AmBD) was the most commonly used agent (66%). Overall mortality rate reached 46%, and risk factors for death were APACHE II score ≥16 (OR = 6.94, CI95% = 2.34–20.58, p<0.0001), and liver disease (OR = 186.11, CI95% = 7.61–4550.20, p = 0.001). Full susceptibility to fluconazole, AmBD and echinocandins among C. albicans, C. tropicalis, and C. parapsilosis was observed. Conclusions The cumulative incidence rate in these centers was higher than other reports from tertiary care hospitals from Latin America. Knowledge of local epidemiologic patterns permits the design of more specific strategies for prevention and preemptive therapy of CBSI.


Revista Argentina De Microbiologia | 2010

La coccidioidomicosis en Argentina, 1892-2009

Cristina Elena Canteros; Adriana Toranzo; B. Ibarra-Camou; V. David; S. G. Carrizo; A. Santillán-Iturres; J. Serrano; Norma Fernández; P. Capece; J. Gorostiaga; Y. Chacón; R. Tonelli; G. Boscaro; C. Abiega; S. Mendieta; C. Fernández; A. Fernández; Roxana G. Vitale; P. Santos; M. R. Pizarro; M. C. López-Joffre; William Lee; Mariana Mazza; G. Posse; Iris Nora Tiraboschi; R. Negroni; Graciela Davel

Clinical cases of coccidioidomycosis are rare in Argentina and are generally found in the large arid precordilleran area of the country. This study aims to perform a retrospective review of all coccidioidomycosis cases documented in the country from 1892 to 2009, and to describe those occurring in the last 4 years. One hundred and twenty eight cases were documented in the 117 year-period. Since the original description of the disease in 1892 until 1939, only 6 cases were registered; between 1940 and 1999, 59 (6-14/10 yrs) and the remaining 63 (49% of total cases) occurred in the last decade. The median age of 34 patients registered in 2006-2009 was 31 years (range: 7-89), male/female ratio was 1.3:1 and 12 patients were immunocompromised. Twenty-six cases were confirmed by direct microscopy and/or culture whereas the remaining ones by serology. All isolates were identified as Coccidioides posadasii. Thirty patients lived in a vast geographic region with epicenter in Catamarca Valley. Between 2006 and 2009, annual disease incidence rates in Catamarca Province increased from historical values below 0.5/100,000 to 2/100,000 inhabitants. Such increase suggests an emergency of coccidioidomycosis in that region.


Journal of Clinical Microbiology | 2012

First Case Report of Bloodstream Infection Due to a Candida Species Closely Related to the Novel Species Candida pseudorugosa

Constanza Giselle Taverna; Susana Córdoba; Guillermina Isla; Norma Fernández; Susana García; Mariana Mazza; Omar Alejandro Murisengo; Walter Vivot; Wanda Szusz; Graciela Davel; Iris Nora Tiraboschi; María Eugenia Bosco-Borgeat

ABSTRACT Candida pseudorugosa is a novel species closely related to Candida rugosa for which only one case has been reported. We report the first case of a bloodstream infection in humans caused by a Candida sp. closely related to C. pseudorugosa. We contribute evidence to show this organism as a potential human pathogen that may be misidentified by conventional methods, also pointing out its lower sensitivity to azoles and other antifungal agents.


Revista Iberoamericana De Micologia | 2013

Recommendations for the management of candidemia in children in Latin America

María Elena Santolaya; Flavio de Queiroz Telles; Tito Alvarado Matute; Arnaldo Lopes Colombo; Jeannete Zurita; Iris Nora Tiraboschi; Jorge Alberto Cortés; Luis Thompson-Moya; Manuel Guzman-Blanco; Jose Sifuentes; Juan Echevarría; Marcio Nucci


Revista Argentina De Microbiologia | 2009

Diagnóstico molecular de histoplasmosis humana en muestras de sangre entera

Adriana Toranzo; Iris Nora Tiraboschi; Norma Fernández; B. Ibarra-Camou; Marta Rivas; William Lee; Graciela Davel; Cristina Elena Canteros


Revista Iberoamericana De Micologia | 2013

Recomendaciones para el manejo de la candidemia en neonatos en América Latina

María Elena Santolaya; Tito Alvarado Matute; Flavio de Queiroz Telles; Arnaldo Lopes Colombo; Jeannete Zurita; Iris Nora Tiraboschi; Jorge Alberto Cortés; Luis Thompson-Moya; Manuel Guzman-Blanco; Jose Sifuentes; Juan Echevarría; Marcio Nucci

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Arnaldo Lopes Colombo

Federal University of São Paulo

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Marcio Nucci

Federal University of Rio de Janeiro

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Jorge Alberto Cortés

National University of Colombia

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Jeannete Zurita

Pontificia Universidad Católica del Ecuador

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Norma Fernández

University of Buenos Aires

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Juan Echevarría

Cayetano Heredia University

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