Irma O. Mastronardi

Stress by forced swimming in the rat: Effects of mianserin and moclobemide on gabaergic-monoaminergic systems in the brain

The stress caused by forced swimming in male rats provoked a decrease in brain NA levels without changes in DA and 5-HT content, MAO and GABAergic activity. Acute or chronic treatment with mianserin did not modify the decrease in NA concentration in the brain of stressed rats. Acute treatment with moclobemide (IMAO) did not modify the decrease in NA content caused by stress; chronic treatment blocked the decrease in NA content in stressed rats.

Two novel metabolites ofAspergillus fonsecaeus

DelAspergillus fonsecaeus (N. R. R. L. 67, O 16-1) se han aislado dos nuevos pigmentos que fueron identificados como monometil éteres de la fonsecina y de la rubrofusarina, respectivamente.

Effects of acute administration or chronic ethanol ingestion on sexual organs monoamine levels in male rats

1. Acute or chronic treatment with ethanol modify the monoamine levels in epididymis (body, tail) and prostate, without changes in head epididymis and seminal vesicle of male rats. 2. The prostate seems to be the most affected in acute treatment while the epididymis body is altered after prolonged exposure to ethanol.

Bupropion. Effects on cerebral monoamines in rat and on blood pressure in dog

Intravenous injections of bupropion into the femoral vein of dogs did not change cardiovascular peripheric responses because it did not affect significantly either arterial pressure or heart rate. In acute experiments bupropion increased the levels of DA, NA and 5-HT in the brain of rats. There was a remarkable correlation between the levels of monoamines and the hypermotility.

Starvation and dehydration: Effect on hypothalamic monoamines and serum LH and prolactin

1. Rats submitted to starvation or water deprivation showed a decrease in LH and prolactin serum levels. 2. 5-HT was increased without changes in DA and NA in cerebral cortex of starved rats. 3. Neurotransmitters did not change in hypothalamus of starved rats but water deprivation decreased NA and increased 5-HT.