Irvin H. Blank

TKANSPORT INTO AND WITHIN THE SKIN

SUMMARY.— Developments in recent years permit us to state the following principles which relate to percutaneous absorption. (1) The entire stratum corneum junctions as the rate‐limiting barrier in the skin. (2) For penetration from weak solutions, flux is directly proportional to the concentration of the penetrant in the solution which is presented to the cutaneous surface. (3) Flux increases as the solubility of the penetrant in the stratum corneum increases. (4) Flux increases as the mobility of the penetrant in the stratum corneum (diffusion constant) increases. (5) Flux decreases as the thickness of the membrane increases. (6) When concentrations in the presenting solution reach high values, flux is not proportional to concentration. (7) Flux through dermal tissue is much more rapid than flux through the stratum corneum.

Clinical Dermatology: Cutaneous Investigation in Health and Disease: Noninvasive Methods and Instrumentation

It is somewhat difficult to understand why the primary title of this book is Cutaneous Investigation in Health and Disease and that it is the first book in a series entitled Clinical Dermatology . It is not clinically oriented and rarely mentions any disease. The book, however, will be very useful in several areas of clinical investigation and describes many noninvasive methods and instrumentation; this is the books secondary title. This book is directed mostly toward methods used for the measurement of physical characteristics of the skin. Although methods for measuring the mechanical, thermal, optical, electrical, and acoustic properties of a substance have been available for many years, they have been used much more in the physical rather than the biological domain. This book covers the application and adaptation of these methods to human skin, areas covered also by the recent journal, Bioengineering and the Skin . Specific physical properties of the

The Dermatology Foundation

THE DERMATOLOGY foundation, of course, is a mere infant as compared to the five other groups whose representatives you have just heard. If we take the incorporation date of the foundation as its birthday, then we can say it has just passed its second birthday. During much of these two years, however, we have been involved with the structuring of the foundation, in getting it incorporated, in getting Internal Revenue Service clearance, and I personally do not consider it even two years old. If we take as its birthday the day on which it opened its New York office, appointed an executive director, Mr. Gerard Speyer, and handled some of the other administrative tasks, then it is only about four months old. Even though young, it seems to me that the Dermatology Foundation is a very healthy, a very active, and an energetic infant. At age two, the foundation