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Irwin H. Lepow

Case Western Reserve University

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Publication

Featured researches published by Irwin H. Lepow.

The New England Journal of Medicine | 1972

Pathways to the complement system.

Irwin H. Lepow; Fred S. Rosen

IT has been well appreciated for many years that the serum complement system, through the concerted action of all its components, is a prime mediator of cytotoxic injury to antibody-sensitized cell...

Experimental Biology and Medicine | 1952

Spectrophotometric Studies on Mixtures of Purified Diphtherial Toxin and Ferriprotoporphyrin IX.

Irwin H. Lepow

Summary Diphtherial toxin-hemin mixtures prepared under a wide range of conditions of pH, ionic strength, buffer ions, molar ratio of hemin to toxin and incubation time have been examined spectrophotometrically. Combination of purified diphtherial toxin with hemin was observed only under conditions leading to non-specific alkali hemi- and hemochrome formation. The significance of these findings to the Pappenheimer proposals relating diphtherial toxin to cytochrome b is discussed.

Science | 1954

The properdin system and immunity. I. Demonstration and isolation of a new serum protein, properdin, and its role in immune phenomena.

Louis Pillemer; Livia Blum; Irwin H. Lepow; Oscar A. Ross; Earl W. Todd; Alastair C. Wardlaw

Journal of Experimental Medicine | 1956

The properdin system and immunity. III. The zymosan assay of properdin.

Louis Pillemer; Livia Blum; Irwin H. Lepow; Leona Wurz; Earl W. Todd

Journal of Experimental Medicine | 1963

CHROMATOGRAPHIC RESOLUTION OF THE FIRST COMPONENT OF HUMAN COMPLEMENT INTO THREE ACTIVITIES

Irwin H. Lepow; George B. Naff; Earl W. Todd; Jack Pensky; C. F. Hinz

Journal of Experimental Medicine | 1967

COMPLEMENT AS A MEDIATOR OF INFLAMMATION : III. PURIFICATION OF THE ACTIVITY WITH ANAPHYLATOXIN PROPERTIES GENERATED BY INTERACTION OF THE FIRST FOUR COMPONENTS OF COMPLEMENT AND ITS IDENTIFICATION AS A CLEAVAGE PRODUCT OF C'3

W.Dias da Silva; John W. Eisele; Irwin H. Lepow

Journal of Experimental Medicine | 1967

Complement as a mediator of inflammation. II. Biological properties of anaphylatoxin prepared with purified components of human complement.

W.Dias da Silva; Irwin H. Lepow

Journal of Immunology | 1968

Properties of Highly Purified Human Properdin

Jack Pensky; Carl F. Hinz; Earl W. Todd; Ralph J. Wedgwood; John T. Boyer; Irwin H. Lepow

Experimental Biology and Medicine | 1959

Assay and Properties of Serum Inhibitor of C'1-Esterase

Lawrence R. Levy; Irwin H. Lepow

Journal of Experimental Medicine | 1957

SOME PROPERTIES OF AN ESTERASE DERIVED FROM PREPARATIONS OF THE FIRST COMPONENT OF COMPLEMENT

Oscar D. Ratnoff; Irwin H. Lepow

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Louis Pillemer

Case Western Reserve University

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Oscar D. Ratnoff

Case Western Reserve University

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Jack Pensky

Case Western Reserve University

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Livia Blum

Case Western Reserve University

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George B. Naff

Case Western Reserve University

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W.Dias da Silva

Instituto Butantan

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Ira Goodkofsky

University of Connecticut

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Lawrence R. Levy

Case Western Reserve University

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Mary Carol Conroy

Pfizer

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Ralph J. Wedgwood

Case Western Reserve University

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