Isabel Casado
Instituto de Salud Carlos III
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Publication
Featured researches published by Isabel Casado.
European Respiratory Journal | 2011
Olga Parra; Angeles Sánchez-Armengol; M. Bonnin; Adrià Arboix; Francisco Campos-Rodriguez; Jose Perez-Ronchel; J. Durán-Cantolla; G. de la Torre; J.R. González Marcos; M. de la Peña; M. Carmen Jiménez; Fernando Masa; Isabel Casado; M. Luz Alonso; J.L. Macarrón
The aim of the present study was to assess the impact of nasal continuous positive airway pressure (nCPAP) in ischaemic stroke patients followed for 2 yrs. Stroke patients with an apnoea–hypopnoea index ≥20 events·h−1 were randomised to early nCPAP (n = 71; 3–6 days after stroke onset) or conventional treatment (n = 69). The Barthel Index, Canadian Scale, Rankin Scale and Short Form-36 were measured at baseline, and at 1, 3, 12 and 24 months. The percentage of patients with neurological improvement 1 month after stroke was significantly higher in the nCPAP group (Rankin scale 90.9 versus 56.3% (p<0.01); Canadian scale 88.2 versus 72.7% (p<0.05)). The mean time until the appearance of cardiovascular events was longer in the nCPAP group (14.9 versus 7.9 months; p = 0.044), although cardiovascular event-free survival after 24 months was similar in both groups. The cardiovascular mortality rate was 0% in the nCPAP group and 4.3% in the control group (p = 0.161). Early use of nCPAP seems to accelerate neurological recovery and to delay the appearance of cardiovascular events, although an improvement in patients’ survival or quality of life was not shown.
Parasitology Research | 2008
María Luisa Caballero; Ignacio Moneo; Fernando Gómez-Aguado; María Teresa Corcuera; Isabel Casado; Rosa Rodriguez-Perez
Allergens Ani s 1 and Ani s 4 have demonstrated their utility for the diagnosis of the sensitization to larvae of the genus Anisakis. The aim was to determine the number of patients with compatible clinical history, who did not recognize Ani s 1 and Ani s 4, and characterize the allergens responsible for their sensitization. Eighty-four patients were studied by CAP and immunoglobulin E (IgE) immunoblotting. The 12% of the patients recognized allergens different from Ani s 1 and Ani s 4, being half sensitized to a heat-resistant 15-kDa allergen, which was isolated by ethanol fractionation, followed by a hydroxyapatite chromatography and a reversed-phase high-performance liquid chromatography and identified by its amino terminal sequence as Ani s 5. A total of 41 of the 84 patients studied (49%) showed specific IgE to Ani s 5 that was detected among the excretory–secretory products and immunohistochemically located at the excretory gland, ventriculus, and the luminal surface of the intestinal epithelium of the larvae.
Clinical and Vaccine Immunology | 2004
Carlos Toro; María Luisa Caballero; Margarita Baquero; Javier García-Samaniego; Isabel Casado; Margarita Rubio; Ignacio Moneo
ABSTRACT Finding evidence of anisakidosis requires invasive methods. We have developed a serological assay based on the detection of an immunoglobulin E (IgE) specifically directed against Ani s 1 protein, a major parasite allergen of Anisakis simplex, which has shown a high level of accuracy in the diagnosis of anisakidosis. We used this tool to determine the prevalence of anti-Ani s 1 IgE in dyspeptic patients and to investigate if its seropositivity could be related to epidemiological factors other than raw fish consumption. A total of 174 dyspeptic patients who submitted to upper digestive tract endoscopy were studied. Specific IgE against Ani s 1 was determined by immunoblotting. Quantitative information on smoking, alcohol consumption, and fish consumption as well as a history of gastric surgery was recorded. Twenty-four (13.8%) patients were seropositive for Ani s 1 protein. The seroprevalence of anti-Ani s 1 IgE increased with age in patients who were less than 62 years old (P = 0.047). Seropositivity to Ani s 1 was associated with the consumption of fish in vinegar (P < 0.001), raw fish (P = 0.001), and smoked fish (P = 0.007). There was no relationship between anti-Ani s 1 IgE seropositivity and the number of cigarettes smoked (P = 0.098) or alcohol intake (P = 0.179). Five patients had undergone previous gastric surgery, and three of those patients were seropositive for Ani s 1 (P = 0.019). In multivariate analysis, the consumption of fish in vinegar (P = 0.006), raw fish (P = 0.017), and smoked fish (P = 0.002) and a history of gastric surgery (P = 0.005) were independent factors associated with anti-Ani s 1 IgE detection. In conclusion, at present, anisakidosis might frequently be underdiagnosed, and it might have a clinical role in patients with upper dyspeptic symptoms. Uncooked-fish ingestion and previous gastric surgery were associated with seropositivity for Ani s 1 protein.
Actas Dermo-Sifiliográficas | 2006
Luis Conde-Salazar; Jorge Angulo; E. González-Guerra; Luis Requena; Isabel Casado; Roberto Blancas
Aquagenic syringeal acrokeratoderma is an infrequently described acquired, transitory keratoderma that is exacerbated when the palms and/or soles are immersed in water. It manifests as whitish or yellowish flattened, translucent papules and plaques, located in areas of pressure or trauma on the palms and/or soles. Involvement is usually bilateral. The histologic features are non-specific, showing a slight dilation of the intraepidermal portion of the eccrine sweat duct. The process tends to remit spontaneously. We present the case of two women, aged 20 and 21.
Cirugia Espanola | 2012
Benigno Acea; Lourdes Calvo Martínez; Silvia Antolín Novoa; Luis Albaina Latorre; Manuel Juaneda Magdalena; Paz Santiago Freijanes; Carmen Silva Rodríguez; Joaquín Mosquera Oses; José R. Varela Romero; Rafael Soler Fernández; Isabel Facio Villanueva; Isabel Casado; Carmen Cereijo Garea
Sentinel lymph node (SLN) biopsy is the standard of practice for assessing axillary spread in clinically node-negative breast cancer patients. On the other hand, axillary lymph node dissection (ALND) is the ideal procedure for patients with SLN metastasis. Different studies over the last few years have suggested that some patients with positive SLN can be treated without ALND. This article presents a literature review carried out by our multidisciplinary group and its strategy for avoiding routine ALND in women with SLN metastases. In this new strategy ALND should not be performed on women with T1 tumours, with 1-2 positive SLN and undergoing breast conservative surgery. On the other hand, ALND would be indicated in those patients with three or more positive SLN, presence of extracapsular invasion, mastectomised women and triple negative subtype or HER2+ tumours that have not received biological treatment with antibodies.
Journal of Gastrointestinal Surgery | 2007
Marta Méndez-López; Magdalena Méndez; Fernando Sánchez-Patán; Isabel Casado; Maria-Angeles Aller; Laudino López; Maria-Teresa Corcuera; Maria-Jose Alonso; Maria-Paz Nava; Jaime Arias; Jorge-Luis Arias
Medicina Clinica | 2005
M. Eulalia Valencia; Victoria Moreno; Pilar Martinez; Isabel Casado
Cirugia Espanola | 2006
Fernando Sánchez-Patán; María Ángeles Aller; María Teresa Corcuera; Elena Vara; Isabel Casado; Fernando Gómez; Cruz García; María José Alonso; Jaime Arias
Cirugia Espanola | 2006
Fernando Sánchez-Patán; María Ángeles Aller; María Teresa Corcuera; Elena Vara; Isabel Casado; Fernando Gómez; Cruz García; María José Alonso; Jaime Arias
Archive | 2006
Luis Conde-Salazar; Jorge Angulo; E. González-Guerra; Luis Requena; Isabel Casado; Roberto Blancas